Adiposopathy and epigenetics: an introduction to obesity as a transgenerational disease

Bays, Harold; Scinta, Wendy

doi:10.1185/03007995.2015.1087983

Cited by 37 publications

(29 citation statements)

References 73 publications

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“…Maternal obesity, glycaemic control, and dietary intake during pregnancy all contribute to the metabolic state of the mother . This in‐utero environment impacts growth and development of the fetus and may alter the epigenome, which determines the expression of the genetic code, and thereby may drive changes in the metabolic phenotype of the child . Consistent with this, studies show that a child born LGA to a mother with gestational diabetes has a 50% risk of developing components of the metabolic syndrome, such as obesity, by the time they start school .…”

Section: Rationale For the Management Of Obesity Prior To Conceptionmentioning

confidence: 98%

Preconception management of women with obesity: A systematic review

et al. 2018

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The prevalence of women of child-bearing age with obesity continues to rise at an alarming rate. This has significant implications for both the short-term and longterm health of mother and offspring. Given the paucity of evidence-based literature in this field, the preconception management of women with obesity is highly variable both between institutions and around the world. This systematic review aims to evaluate studies that inform us about the role of preconception weight loss in the fertility and pregnancy outcomes of women with obesity. Current therapeutic interventions are discussed, with a specific focus on the suitability of weight loss interventions for women with obesity planning pregnancy. There are significant knowledge gaps in the current literature; these are discussed and areas for future research are explored.

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Section: Rationale For the Management Of Obesity Prior To Conceptionmentioning

confidence: 98%

Preconception management of women with obesity: A systematic review

et al. 2018

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“…In the general population, the fat‐mass and obesity associated gene ( FTO ) has shown the strongest association to obesity . Besides these polygenic associations that have not been fully elucidated as yet, only a small percentage of the patients with obesity can be classified as having a monogenic or syndromic obesity disorder …”

Section: Assessment Of Obesity—clinical Historymentioning

confidence: 99%

A comprehensive diagnostic approach to detect underlying causes of obesity in adults

et al. 2019

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SummaryObesity is a worldwide growing problem. When confronted with obesity, many health care providers focus on direct treatment of the consequences of adiposity. We plead for adequate diagnostics first, followed by an individualized treatment. We provide experience‐based and evidence‐based practical recommendations (illustrated by clinical examples), to detect potential underlying diseases and contributing factors. Adult patients consulting a doctor for weight gain or obesity should first be clinically assessed for underlying diseases, such as monogenetic or syndromic obesity, hypothyroidism, (cyclic) Cushing syndrome, polycystic ovarian syndrome (PCOS), hypogonadism, growth hormone deficiency, and hypothalamic obesity. The most important alarm symptoms for genetic obesity are early onset obesity, dysmorphic features/congenital malformations with or without intellectual deficit, behavioral problems, hyperphagia, and/or striking family history. Importantly, also common contributing factors to weight gain should be investigated, including medication (mainly psychiatric drugs, (local) corticosteroids, insulin, and specific β‐adrenergic receptor blockers), sleeping habits and quality, crash diets and yoyo‐effect, smoking cessation, and alcoholism. Other associated conditions include mental factors such as chronic stress or binge‐eating disorder and depression.Identifying and optimizing the underlying diseases, contributing factors, and other associated conditions may not only result in more effective and personalized treatment but could also reduce the social stigma for patients with obesity.

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“…However, obesity has several inheritance patterns: genetic mutations and alterations, familial/cultural/ societal inherited influences, as well as the increasingly recognized importance of epigenetic inheritance. [3] Examples of rare genetic causes of obesity include melanocortin 4 receptor deficiency, Albright's hereditary osteodystrophy, Prader-Willi syndrome, Bradet-Biedl syndrome, Borjeson-Forssman-Lehmann syndrome, and Cohen syndrome. [3] Epigenetic factors and regulation in obesity…”

Section: Policy On Privacy and Confidentialitymentioning

confidence: 99%

“…[3] Examples of rare genetic causes of obesity include melanocortin 4 receptor deficiency, Albright's hereditary osteodystrophy, Prader-Willi syndrome, Bradet-Biedl syndrome, Borjeson-Forssman-Lehmann syndrome, and Cohen syndrome. [3] Epigenetic factors and regulation in obesity…”

Section: Policy On Privacy and Confidentialitymentioning

confidence: 99%

Proactive and Progressive Approaches in Managing Obesity

Eckel

Bays

Klein

et al. 2016

Postgraduate Medicine

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Despite the advice clinicians have been giving patients about the importance of restricting their food intake and increasing physical activity levels, the Centers for Disease Control and Prevention (CDC) states that 78.6 million adults in the United States (US) are still obese. With these statistics in mind, this symposium provided insights on the genetic, cultural, and environmental underpinning of obesity and discussed the latest research on pharmacotherapy, surgery, and the need to individualize treatment.

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Adiposopathy and epigenetics: an introduction to obesity as a transgenerational disease

Cited by 37 publications

References 73 publications

Preconception management of women with obesity: A systematic review

Preconception management of women with obesity: A systematic review

A comprehensive diagnostic approach to detect underlying causes of obesity in adults

Proactive and Progressive Approaches in Managing Obesity

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