Adjunctive efficacy of systemic metronidazole in the surgical treatment of periodontitis: a double-blind parallel randomized clinical trial

Collins, Jim; Ogando, Gabriel; G, Ricardo Espinoza; Figuero, Elena; Marín, María J.; Sanz, Mariano; Herrera, David

doi:10.1007/s00784-022-04392-2

Cited by 5 publications

(4 citation statements)

References 40 publications

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“…A total of 15 studies (Aimetti et al, 2020; Barbe et al, 2020; Baumer et al, 2020; Ciurescu et al, 2021; Collins et al, 2022; Cortellini et al, 2020; De Wet et al, 2018; Graetz et al, 2020; Jiao et al, 2017, 2018; Nibali et al, 2017; Nibali et al, 2020; Saleh et al, 2021; Saydzai et al, 2022; Sonnenschein et al, 2017) were included in the qualitative and quantitative analyses (Tables 1 and 2). They included 3 RCTs (both test and control groups were considered in the analyses), 10 cohort (1 prospective and 9 retrospective) and 2 cross‐sectional studies.…”

Section: Resultsmentioning

confidence: 99%

“…Corresponding authors of the 62 articles considered potentially suitable for inclusion were contacted for confirmation that all requested data were available. IPD were available for nine studies (Barbe et al, 2020;Ciurescu et al, 2021;Collins et al, 2022;Cortellini et al, 2020;De Wet et al, 2018;Nibali et al, 2017Nibali et al, , 2020Saleh et al, 2021;Saydzai et al, 2022) and summaries of the requested data were made available via completed contingency tables for a further six studies (Aimetti et al, 2020;Baumer et al, 2020;Graetz et al, 2020;Jiao et al, 2017Jiao et al, , 2018Sonnenschein et al, 2017). There were no important issues in checking IPD integrity.…”

Section: Study Selectionmentioning

confidence: 99%

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Prevalence of stable and successfully treated periodontitis subjects and incidence of subsequent tooth loss within supportive periodontal care: A systematic review with meta‐analyses

Rattu

Raindi

Antonoglou

et al. 2023

J Clinic Periodontology

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AimTo identify (i) the prevalence of meeting the endpoints of ‘stable periodontitis’ (probing pocket depth [PPD] ≤ 4 mm, bleeding on probing [BoP] < 10%, no BoP at 4 mm sites), ‘endpoints of therapy’ (no PPD > 4 mm with BoP, no PPD ≥ 6 mm), ‘controlled periodontitis’ (≤4 sites with PPD ≥ 5 mm), ‘PPD < 5 mm’ and ‘PPD < 6 mm’ at the start of supportive periodontal care [SPC]) and (ii) the incidence of tooth loss in relation to not meeting these endpoints within a minimum of 5 years of SPC.Materials and MethodsSystematic electronic and manual searches were conducted to identify studies where subjects, upon completion of active periodontal therapy, entered into SPC. Duplicate screening was performed to find relevant articles. Corresponding authors were contacted to confirm inclusion and retrieve required clinical data for further analyses to assess the prevalence of reaching endpoints and incidence of subsequent tooth loss, if available, within at least 5 years of SPC. Meta‐analyses were carried out to evaluate risk ratios for tooth loss in relation to not reaching the various endpoints.ResultsFifteen studies including 12,884 patients and 323,111 teeth were retrieved. Achievement of endpoints at baseline SPC was rare (1.35%, 11.00% and 34.62%, respectively, for ‘stable periodontitis’, ‘endpoints of therapy’ and ‘controlled periodontitis’). Less than a third of the 1190 subjects with 5 years of SPC data lost teeth—a total of 3.14% of all teeth were lost. Statistically significant associations with tooth loss, at the subject‐level, were found for not achieving ‘controlled periodontitis’ (relative risk [RR] = 2.57), PPD < 5 mm (RR = 1.59) and PPD < 6 mm (RR = 1.98).ConclusionsAn overwhelming majority of subjects and teeth do not achieve the proposed endpoints for periodontal stability, yet most periodontal patients preserve most of their teeth during an average of 10–13 years in SPC.

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Section: Resultsmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Prevalence of stable and successfully treated periodontitis subjects and incidence of subsequent tooth loss within supportive periodontal care: A systematic review with meta‐analyses

Rattu

Raindi

Antonoglou

et al. 2023

J Clinic Periodontology

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“…As for the methods of detection of P. gingivalis the vast majority of the articles address the use of the PCR method, due to the specificity of results and time of execution, such that of each quadrante, the place with the deepest depth of probe was selected for the collection of subgingival samples for microbiological analysis. "The bacterial DNA was then extracted and processed with quantitative PCR to detect and quantify the pathogen of interest" [23].…”

Section: Treatment Of Wastementioning

confidence: 99%

Antimicrobial Sensitivity Associated with Porphyromonas gingivalis Present in Periodontitis Frameworks: An Integrative Review

Araújo,

Silva,

Prado

2024

ACRI

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Objectives: The Gram-negative anaerobic bacterium Porphyromonas gingivalis is identified as one of the most important causes of the chronic form of periodontitis. This work aimed to analyze the sensitivity of P. gingivalis to antibiotics and antimicrobial agents. Study Design: Integrative literature review. Methodology: Through a careful analysis of clinical trials published in the last 5 years. A bibliographic search was carried out in the PubMed, Scielo and Google Scholar databases. Three keywords were established and verified on the DeCs-Descritores em Ciências da Saúde website for the literary search “Antimicrobial resistance”, “Periodontal biotherapy” and “Porphyromonas gingivalis”. 66 articles were found. Of these, animal studies, studies that did not involve patients diagnosed with periodontitis according to the 2017 World Workshop on the Classification of Periodontal and Peri-implant Diseases and Conditions, and studies on peri-implantitis were excluded. Studies that used only surgical therapy without association with at least one antibiotic or antimicrobial and duplicate studies were excluded. Results: This integrative review presents the results of 19 studies. Amoxicillin, Metronidazole and Azithromycin are the most commonly used antibiotics. Photodynamic therapy has demonstrated benefits in reducing inflammation and P. gingivalis counts. It has been demonstrated that P. gingivalis is not sensitive to Lactobacillus brevis and Lactobacillus plantarum-ProlcSan probiotic gel and tablets, as no reductions in its proportion and total count were observed. Similar results were also observed in the study that investigated the effect of administering piperacillin plus Tazobactam gel and doxycycline gel. Conclusion: Although most of the articles presented report the sensitivity of P. gingivalis to their protocols, microbiological reduction is not always accompanied by clinical benefit, since periodontal disease is multifactorial. Based on these findings, it is concluded that there are several antimicrobial agents capable of promoting the reduction of this key pathogen in periodontitis.

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“…Eine aktuelle placebokontrollierte, randomisierte Studie ist der Frage nachgegangen, ob die einwöchige Gabe von Metronidazol (500 mg, 3-mal täglich) die Ergebnisse parodontaler Zugangslappenoperationen verbessern könnte [40]. Insgesamt war die Inzidenz unerwünschter Ereignisse minimal, allerdings gaben 20 % der Patienten der Antibiotikagruppe gastrointestinale Beschwerden an.…”

Section: Antibiotische Begleittherapieunclassified

Antibiotika in der parodontalen Therapie

Jepsen¹,

Cosgarea²,

Jervøe‐Storm³

2022

Zahnmedizin up2date

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Adjunctive efficacy of systemic metronidazole in the surgical treatment of periodontitis: a double-blind parallel randomized clinical trial

Cited by 5 publications

References 40 publications

Prevalence of stable and successfully treated periodontitis subjects and incidence of subsequent tooth loss within supportive periodontal care: A systematic review with meta‐analyses

Prevalence of stable and successfully treated periodontitis subjects and incidence of subsequent tooth loss within supportive periodontal care: A systematic review with meta‐analyses

Antimicrobial Sensitivity Associated with Porphyromonas gingivalis Present in Periodontitis Frameworks: An Integrative Review

Antibiotika in der parodontalen Therapie

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