Adjuvant Analgesics in Acute Pain Management

Ruel, H; Steagall, Paulo V.

doi:10.1016/j.cvsm.2019.07.005

Cited by 23 publications

(24 citation statements)

References 74 publications

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“…The treatment for this problem is mainly constituted by the administration of non-steroidal anti-inflammatory drugs (NSAIDs), which produce an anti-inflammatory, antipyretic, and analgesic effect and include a broad variety of formulations and doses [4]. NSAIDs have the capacity to block the synthesis of prostaglandins (PGs) by the inhibition of the cyclooxygenase enzymes (COX-1 and COX-2).…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive Effect of Hinokinin and Kaurenoic Acid Isolated from Aristolochia odoratissima L.

et al. 2020

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Aristolochia odoratissima L. is employed for the treatment of pain and as an antidote against the poison of venomous animals in traditional medicine. However, reports have not been found, to our knowledge, about the evaluation of the antinociceptive activity of extracts nor about the presence of compounds associated with this activity. Thus, the purpose of this work was to evaluate the antinociceptive activity of extracts and compounds isolated from the stems of Artistolochia odoratissima L. The extracts were obtained with solvents of increasing polarity and the compounds were isolated and characterized by column chromatography, HPLC, and NMR. The antinociceptive activity was carried out by the formalin test in mice. Ethyl acetate (AoEA) and methanolic (AoM) extracts decreased the paw licking in both phases of the formalin test. The isolated compounds (kaurenoic acid and hinokinin) from AoEA showed the highest antinociceptive activity in both phases of the formalin test. These results confirmed the analgesic effect of this specie described in traditional medicine and provided a base for a novel analgesic agent. They also allowed an approach for the development of standardized plant extracts with isolated metabolites.

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Section: Introductionmentioning

confidence: 99%

Antinociceptive Effect of Hinokinin and Kaurenoic Acid Isolated from Aristolochia odoratissima L.

et al. 2020

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“…Postoperative analgesia was also translated from the small animal literature. We opted to associate gabapentin since it is a promising postoperative analgesic tool, confirmed by recent studies (Ruel and Steagall, 2019). We did not consider physical therapy in this case due to the animal's aggressive behavior, even though it is known to be an important factor that improves recovery after neurological surgeries.…”

Section: Discussionmentioning

confidence: 98%

Pediculectomy and fenestration for spinal cord decompression of the lumbar spine of a bush dog (Speothos venaticus) - case report

Marinho

Macedo

Ferrigno

et al. 2020

Arq. Bras. Med. Vet. Zootec.

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A captive adult male bush dog (Speothos venaticus) was referred to our Veterinary Medical Teaching Hospital from a local zoo due to a two-week history of progressive hind limb gait impairment and ataxia, non-responsive to clinical management. Computed tomography revealed decreased disc space at L3 - L4 level, with probable disc extrusion narrowing the right side of the spinal canal, compressing the spinal cord. We opted to surgically remove the disc material using both fenestration and right lateral pediculectomy (mini-hemilaminectomy) techniques. Twelve days after surgery there was mild residual proprioceptive ataxia. Gait was fully regained with remission of the neurological deficits around the 30th postoperative day. This is - to the best of our knowledge - the first successful report of a lumbar intervertebral disc extrusion in a bush dog (Speothos venaticus) surgically treated by pediculectomy and disc fenestration.

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“…IR spectra were recorded on an IR Affinity-1S Infrared spectrophotometer (Shimadzu, Tokyo, Japan). 1 H NMR and 13 C NMR spectra in DMSO-d 6 were recorded on a Bruker Fourier 300 (Bruker Bioscience, Billerica, MA, USA), respectively. MS studies were performed on an LCMS-8040 tandem mass system (Shimadzu, Tokyo, Japan).…”

Section: Chemistrymentioning

confidence: 99%

“…Pain is a health problem affecting the quality of life of patients due to its prevalence and accompanying disabilities. The pharmacological agents used in the treatment of pain include nonsteroidal anti-inflammatory drugs (NSAID), opioid analgesics, and analgesic adjuvants (such as antidepressants and local anesthetics) [1]. Although there are various analgesics used in clinics today, pain management is still a challenge due to concomitant undesirable side effects of these drugs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antinociceptive Effect of Some Thiazole-Piperazine Derivatives: Involvement of Opioidergic System in the Activity

et al. 2021

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In this study, we aimed to design and synthesize novel molecules carrying both the thiazole and piperazine rings in their structures and to investigate their antinociceptive activity. Targeted compounds were obtained by reacting thiosemicarbazide derivative and appropriate 2-bromoacetophenone in ethanol. The structures of the obtained compounds were determined using data from various spectroscopic methods (IR, 1H-NMR, 13C-NMR, and LCMSMS). Experimental data from in vivo tests showed that test compounds 3a–3c, 3f, and 3g (50 mg/kg) significantly prolonged reaction times of animals in tail-clip and hot-plate tests compared to the controls, indicating that these compounds possess centrally mediated antinociceptive activities. Furthermore, these compounds reduced the number of writhing behaviors in the acetic acid-induced writhing tests, showing that the compounds also possess peripheral antinociceptive activity. In the mechanistic studies, naloxone pre-treatments abolished the antinociceptive activities of compounds 3a–3c, 3f, and 3g, indicating that opioidergic mechanisms were involved in their antinociceptive effects. Molecular docking studies demonstrating significant interactions between the active compounds and µ- and δ-opioid receptor proteins supported the pharmacological findings. This study is the first showing that molecules designed to bear thiazole and piperazine moieties together on their structure exert centrally and peripherally mediated antinociceptive effects by activating the opioid system.

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Adjuvant Analgesics in Acute Pain Management

Cited by 23 publications

References 74 publications

Antinociceptive Effect of Hinokinin and Kaurenoic Acid Isolated from Aristolochia odoratissima L.

Antinociceptive Effect of Hinokinin and Kaurenoic Acid Isolated from Aristolochia odoratissima L.

Pediculectomy and fenestration for spinal cord decompression of the lumbar spine of a bush dog (Speothos venaticus) - case report

Synthesis and Antinociceptive Effect of Some Thiazole-Piperazine Derivatives: Involvement of Opioidergic System in the Activity

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