Adjuvant effect of Cliptox™ on the protective immune response induced by an inactivated vaccine against foot and mouth disease virus in mice

Batista, Alexandre; Quattrocchi, Valeria; Olivera, Vivian; Langellotti, Cecilia; Pappalardo, Juan Sebastian; Giacomo, Sebastián Di; Montagnoli, Claudia; Portuondo, Deivys Leandro; Zamorano, Patricia

doi:10.1016/j.vaccine.2010.06.098

Cited by 21 publications

(20 citation statements)

References 18 publications

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“…Their binding induced the activation of DCs and the production of Th1-biased cytokines, such as TNF-α, IL-12, and IFN-γ. Immune response against FMDV in natural hosts is probably T-cell dependent, and cell-mediated immunity may be involved in the clearance of persistent FMDV [23]. Ideally, a FMDV vaccine should be able to prime Th1/Th2-balanced immune responses to eliminate FMDV infection.…”

Section: Discussionmentioning

confidence: 99%

Resiquimod and polyinosinic–polycytidylic acid formulation with aluminum hydroxide as an adjuvant for foot-and-mouth disease vaccine

Zhou

Chen

et al. 2014

BMC Vet Res

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BackgroundToll-like receptor (TLR) agonists reportedly have potent antiviral and antitumor activities and may be a new kind of adjuvant for enhancing immune efficacy. Resiquimod (R848) is an imidazoquinoline compound with potent antiviral activity and functions through the TLR7/TLR8 MyD88-dependent signaling pathway. Polyinosinic-polycytidylic acid [poly(I:C)] is a synthetic analog of double-stranded RNA that induces the production of pro-inflammatory cytokines by the activation of NF-κB through TLR3. This study investigated the potential of R848 and poly(I:C) as an adjuvant 146S foot-and-mouth disease virus (FMDV) vaccine formulated with aluminum hydroxide (Al(OH)3).ResultsAntibody titers to FMDV and CD8+ T cells were markedly enhanced in mice immunized to 146S FMDV + Al(OH)3 + R848 + poly(I:C) compared with mice immunized to FMDV + ISA206. IFN-γ secretion substantially increased compared with IL-4 secretion by splenic T cells stimulated with FMDV antigens in vitro, suggesting that R848, poly(I:C), and with Al(OH)3 together biased the immune response toward a Th1-type direction.ConclusionsThese results indicated that the R848 and poly(I:C) together with Al(OH)3 enhanced humoral and cellular immune responses to immunization with 146S FMDV antigens. Thus, this new vaccine formulation can be used for FMDV prevention.

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Section: Discussionmentioning

confidence: 99%

Resiquimod and polyinosinic–polycytidylic acid formulation with aluminum hydroxide as an adjuvant for foot-and-mouth disease vaccine

Zhou

Chen

et al. 2014

BMC Vet Res

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“…As oil immune adjuvants are absorbed more slowly than their gel equivalents, they can cause local reactions in vaccinated sites. In order to remove such effects, the use of other immune adjuvant types than the oil type, such as nanoparticles and toll-like receptor ligands, should also be taken into account [10,55-57]. However, the global market has not proposed new immune adjuvants that are sufficiently proven to allow them to replace the oil-type adjuvants thus far.…”

Section: Development Strategy For Improved Fmd Vaccinementioning

confidence: 99%

Requirements for improved vaccines against foot-and-mouth disease epidemics

Park

2013

Clin Exp Vaccine Res

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Inactivated foot-and-mouth disease (FMD) vaccines are currently used worldwide. With the emergence of various FMD virus serotypes and subtypes, vaccines must become more suitable for field-based uses under the current circumstances in terms of the fast and proper selection of vaccine strains, an extended vaccine development period for new viruses, protecting against the risk of virus leakage during vaccine manufacture, counteracting the delayed onset of immune response, counteracting shorter durations of immunity, and the accurate serological differentiation of infected and vaccinated animals and multiple vaccination. The quality of vaccines should then be improved to effectively control FMD outbreaks and minimize the problems that can arise among livestock after vaccinations. Vaccine improvement should be based on using attenuated virus strains with high levels of safety. Moreover, when vaccines are urgently required for newly spread field strains, the seed viruses for new vaccines should be developed for only a short period. Improved vaccines should offer superior immunization to all susceptible animals including cattle and swine. In addition, they should have highly protective effects without persistent infection. In this way, if vaccines are developed using new methods such as reverse genetics or vector vaccine technology, in which live viruses can be easily made by replacing specific protective antigens, even a single vaccination is likely to generate highly protective effects with an extended duration of immunity, and the safety and stability of the vaccines will be assured. We therefore reviewed the current FMD vaccines and their adjuvants, and evaluated if they provide superior immunization to all susceptible animals including cattle and swine.

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“…IgG is the most common type of immunoglobulin in the blood and plays a major role in the antibody-mediated defense mechanism. Additionally, IgG provides particularly effective protection against FMDV through antibody-enhanced phagocytosis of the viral particles [2]. For this reason, we measured FMDV-specific IgM levels and total anti-FMDV antibody production.…”

mentioning

confidence: 99%

Dietary germanium biotite supplementation enhances the induction of antibody responses to foot-and-mouth disease virus vaccine in pigs

Lee

Jung

et al. 2014

J Vet Sci

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We evaluated the potential ability of germanium biotite (GB) to stimulate the production of antibodies specific for foot-and-mouth disease virus (FMDV). To this aim, we measured the total FMDV-specific antibody responses and IgM production after vaccination against FMD both experimentally and in the field. GB supplementation with FMDV vaccination stimulated the production of anti-FMDV antibodies, and effectively increased IFN-γ and TNF-α levels. These results suggest that GB may be a novel alternative feed supplement that can serve as a boosting agent and an immunostimulator for increasing the efficacy of FMDV vaccination in pigs.

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Adjuvant effect of Cliptox™ on the protective immune response induced by an inactivated vaccine against foot and mouth disease virus in mice

Cited by 21 publications

References 18 publications

Resiquimod and polyinosinic–polycytidylic acid formulation with aluminum hydroxide as an adjuvant for foot-and-mouth disease vaccine

Resiquimod and polyinosinic–polycytidylic acid formulation with aluminum hydroxide as an adjuvant for foot-and-mouth disease vaccine

Requirements for improved vaccines against foot-and-mouth disease epidemics

Dietary germanium biotite supplementation enhances the induction of antibody responses to foot-and-mouth disease virus vaccine in pigs

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