Adjuvant radiotherapy after excision of cutaneous squamous cell carcinoma

Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline

“…Studies in patients with parotid lymph node involvement experience an improved relapse-free survival by a combination of surgery and RT compared to each modality alone [73][74][75].…”

Radiation Therapy for High-Risk Squamous Cell Carcinomas in Patients with Xeroderma Pigmentosum: Report of Two Cases and Review of the Literature

“…Suboptimal cure rates and potential difficulties with future surgical procedures in previously irradiated skin as well as the risk of radiation-induced malignancies later in life limit the use of RT as a primary treatment modality for skin cancers in individuals with and without XP (especially younger patients) [38]. However, RT represents an important component of multimodal therapy for high-risk SCC [3,4,5,6,7]. In situations such as our patients’ aggressive, recurrent SCCs with extension down to bone, perineural invasion and microscopic regional lymph node metastasis, its benefits in controlling a potentially fatal disease outweigh the risks.…”

“…Radiation therapy (RT) represents an important adjuvant treatment modality for high-risk SCCs with invasion of deep tissues, perineural involvement or regional lymph node metastases [3,4,5,6,7]. Despite the frequency of aggressive cutaneous and extracutaneous malignancies, there have been relatively few reports of RT in individuals with XP [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22].…”

Management of Epithelial Dermatologic Neoplasia

“…The value of adjuvant treatments remains controversial. Adjuvant radiotherapy is believed to have a rationale in managing high-risk cutaneous SCCs after excision, since they otherwise have an increased risk of local recurrence [69]. Elective lymph node removal has to be considered in advanced tumors of the head and neck with poorer prognosis, especially for lip lesions thicker than 6 mm and skin lesions invading more than 8 mm in depth [70].…”