Adjuvant therapies of bone graft around non-cemented experimental orthopedic implants stereological methods and experiments in dogs

Preclinical Evaluation of Zoledronate to Maintain Bone Allograft and Improve Implant Fixation in Revision Joint Replacement

“…The same principles apply to the volume fraction measurements. These techniques provide highly reliable results with negligible bias 19 .…”

The effect of erythropoietin on bone

“…The localization of the three pairs was determined by block randomization, and EPO treatment was either randomized to the left or the right side of the calvaria. These measures ensured that the results were not biased by a possible sitedependent regenerative potential at the three locations (Baas 2008).…”

“…6 weeks in Paper 1 and 5 weeks in Paper 3, therefore were chosen to maximize the chance of finding statistically significant differences between groups. Here, we applied the same rationale as that described by Baas (2008). In this time window, in which the slope of the healing/bone formation rate is steepest, the likelihood of detecting differences between groups peaks (Figure 4).…”

An overview on bone protein extract as the new generation of demineralized bone matrix

“…Therefore, bone graft substitutes must be used and they should have good biocompatibility with the new prosthesis. Fortunately, Baas et al [71,79,95] thoroughly studied the biocompatibility of BPE for bone repair. They designed porous-coated titanium alloy implants, which they combined with different kinds of bone substitute material, and placed the implants in the lateral proximal humerus of dogs.…”