Adjuvant treatment of deep sternal wound infection with collagenous gentamycin

Leyh, Rainer; Bartels, Claus; Sievers, Hans‐Hinrich

doi:10.1016/s0003-4975(99)00836-x

Cited by 40 publications

(61 citation statements)

References 15 publications

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“…GCCI have been successfully used in reducing wound infection following vascular surgery, especially in high risk patients and procedures [10]. The adjuvant therapy with collagenous Gentamycin in combination with surgical debridement gave excellent results in the treatment of deep sternal wound infections [11]. In the presented study, GCCI implantation enabled shorter systemic antibiotic therapy and quicker hospital discharge.…”

Section: Discussionmentioning

confidence: 72%

Comparative study on usefulness of gentamycin-containing collagen implants in the treatment of patients with osteitis and osteomyelitis of the craniofacial skeleton

Zawadzki¹,

Perkowski²,

Kotlarski³

et al. 2017

Ann Agric Environ Med.

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Section: Discussionmentioning

confidence: 72%

Comparative study on usefulness of gentamycin-containing collagen implants in the treatment of patients with osteitis and osteomyelitis of the craniofacial skeleton

Zawadzki¹,

Perkowski²,

Kotlarski³

et al. 2017

Ann Agric Environ Med.

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“…This result was not explained, but it can be argued that the difference may have occurred due to bleeding from the bone marrow from a gap between both sternum halves when two gentamicin-collagen layers were inserted [12]. A similar increase in the number of cases with postoperative bleeding with dehiscence was noted by Leyh et al [9]. In general, topically-administered gentamicin-collagen implants are recommended for antibiotic prophylaxis in a cardiac surgery.…”

Section: Discussionmentioning

confidence: 85%

“…The other advantages of topicallyadministered gentamicin are its high concentration in wound fluid and minimum concentration in serum. High local gentamicin levels, about 75-200 times higher than minimum inhibition concentration (MIC), 4mg/l, were observed in wound fluid compared to that in serum (1-4 mg/l after 24 hours): both levels being safely below the toxic threshold of 10 mg/l [5,[7][8][9].…”

Section: Discussionmentioning

confidence: 97%

“…Most published articles involving topicallyadministered gentamicin with a collagen carrier describe results of the prophylaxis of SSI in a cardiac surgery [5][6][7][8][9][10][11]. Gentamicin-collagen implants of various brand names (Collatamp-G ® , Gentacoll ® , Sulmycin Implant ® ) that contain 130 mg of gentamicin and 280 mg of collagen were put underneath the sternum or between its edges before sternotomy closure.…”

Section: Discussionmentioning

confidence: 99%

“…Gentamicin-collagen implants of various brand names (Collatamp-G ® , Gentacoll ® , Sulmycin Implant ® ) that contain 130 mg of gentamicin and 280 mg of collagen were put underneath the sternum or between its edges before sternotomy closure. In some studies, more than one implant of gentamicin-collagen was applied [9,10,12].…”

Section: Discussionmentioning

confidence: 99%

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TOPICALLY-USED GENTAMICIN ATTACHED TO NANOFIBRE MDOCTM COMPARED WITH GARAMYCIN SCHWAMM<sup>®</sup> IN AN ACUTE WOUND INFECTION MODEL. AN EXPERIMENTAL STUDY.

Lochman¹,

Páral²,

Simkovĭc³

et al. 2012

MMSL

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SummaryThe aim of this study was to examine the effect of topically-used gentamicin attached to a biodegradable carrier, formed by micro-dispersed oxidised cellulose (MDOC) in nanofibre form, in acute wound infection treatment and to compare it with Garamycin Schwamm ® . Twelve domestic swines were used in a model of a full-thickness infected dermal wound. The effectiveness of both materials in wound infections caused by Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli was tested. The effectiveness of both gentamicin with MDOC and Garamycin Schwamm ® was comparable in Pseudomonas aeruginosa and Escherichia coli infections according to microbiological cultures findings. With Staphylococcus aureus infections there was a higher percent of negative cultures when MDOC with gentamicin was administered, but without statistical significance (p=0.069). When macroscopically assesed, 100 % of infected wounds treated by gentamicin attached to MDOC were without signs of local infection compared to only 16.7 % when Garamycin Schwamm ® was used and this was statistically significant (p<0.01). For statistical analysis we used a Fisher´s exact test. When combined with a nanofibre MDOC carrier, topically-used gentamicin seems to be rendered more for treatment of full-thickness skin infections. The resulting good haemostatic effect of MDOC was observed.

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Insight into the interaction of E. coli with gentamycin by ultrafast electrophoresis achieved within the microscopic visual field

2009

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An ultrafast electrophoresis method was developed to have an insight into the interaction of E. coli, DH5alpha, with an antibiotic gentamycin. The method used micro-video to visually measure the migration of bacteria, rather than molecules, within several micrometers, taking a time down to 0.04 s. Precise bacterial mobility was measured at the electric field strength of 42.5-62.5 V/cm, with a mobility deviation of less than 1.7% compared with a common CE method. The bacterial mobility measured this way was found to have a distribution increasing with the electric field strength applied, but the averaged mobility kept constant or independent of the electric field strength. As indicated by the bacterial mobility measured, DH5alpha experienced four stages during interaction with the antibiotic gentamycin, namely, the outer surface adsorption equilibration, uptake or transferring of adsorbed gentamycin through cellular membrane, destruction of the membrane, and death of the bacteria. The bacterial outer surface adsorption of gentamycin was found to have duration up to about 5 min that decreased reversely with the concentration of gentamycin added. This proves that the activity of antibiotic gentamycin is dose-dependent.

show abstract

Adjuvant treatment of deep sternal wound infection with collagenous gentamycin

Cited by 40 publications

References 15 publications

Comparative study on usefulness of gentamycin-containing collagen implants in the treatment of patients with osteitis and osteomyelitis of the craniofacial skeleton

Comparative study on usefulness of gentamycin-containing collagen implants in the treatment of patients with osteitis and osteomyelitis of the craniofacial skeleton

TOPICALLY-USED GENTAMICIN ATTACHED TO NANOFIBRE MDOCTM COMPARED WITH GARAMYCIN SCHWAMM<sup>®</sup> IN AN ACUTE WOUND INFECTION MODEL. AN EXPERIMENTAL STUDY.

Insight into the interaction of E. coli with gentamycin by ultrafast electrophoresis achieved within the microscopic visual field

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