Administration of Asian Herb Bennet (Geum japonicum) Extract Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone

Lim, Dong Wook; Han, Taewon; Um, Min Young; Yoon, Minseok; Kim, Tae‐Eun; Kim, Yun Tai; Han, Dongil; Lee, Jaekwang; Lee, Chang Ho

doi:10.3390/nu11122841

Cited by 20 publications

(12 citation statements)

References 39 publications

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“…Liu et al, 2018). We determined that immobility time was signi cantly increased in the TST and FST as well as decreased sucrose consumption in mice receiving 40 mg/kg of CORT daily, and this study showed a similar trend to that of a previous study (Lim et al, 2019b). As expected, we found that the PRE-treated group had signi cantly reduced immobility time in the TST and FST without any changes in locomotor activity, especially at the 300 mg/kg dose; this antidepressant-like effect was similar to that of the group receiving St. John's wort extract as a positive control.…”

Section: Discussionsupporting

confidence: 82%

“…The SPT was performed 24 hours after OFT, following a previously established protocol (Lim et al, 2019a). The two bottles contained the 1% sucrose solutions were located in the cage for 24 h. Next, one of the bottle of the sucrose solution was located with water for 24 h. The mice then were placed in cages individually with free access to the two bottles for 24 h, and the consumed volumes were recorded.…”

Section: Sucrose Preference Test (Spt)mentioning

confidence: 99%

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Pedicularis resupinata restores corticosterone-induced depressive-like behaviors in mice via glucocorticoid receptor-mediated BDNF expression

Lim

Han

Lee

2022

Preprint

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Excessive corticosterone (CORT), resulting from a dysregulated hypothalamic–pituitary–adrenal (HPA) axis, is associated with cognitive impairment and behavioral changes, including depression. In Eastern medicine, Pedicularis resupinata var. oppositifolia (Scrophulariaceae) is used for the treatment of rheumatoid arthritis, malignant abscesses (tumors), uroliths, and diuretics. However, the antidepressant properties of P. resupinata have not been well characterized. Here, the antidepressant-like effects of P. resupinata extract (PRE) were evaluated in in vivo and in vitro CORT-induced depression models. HPLC confirmed that acteoside, a phenylethanoid glycoside, was a major PRE compound from. Male ICR mice (8 weeks old) were injected with CORT (40 mg/kg) and orally administered PRE daily (30, 100, and 300 mg/kg) for 21 consecutive days. Depressive-like behaviors were evaluated using the open field test, sucrose preference test, passive avoidance test, tail suspension test, and forced swim test. Treatment with a high dose of PRE significantly alleviated CORT-induced depression-like behaviors in mice and reduced neurotoxicity in a concentration-dependent manner in SH-SY5Y cells. Additionally, repeated CORT injection markedly reduced brain-derived neurotrophic factor (BDNF) levels, whereas total glucocorticoid receptor (GR) and GR phosphorylation at serine 211 were significantly increased in the mice hippocampus, but improved by PRE treatment. Thus, our findings suggest that PRE have potential antidepressant-like effects by modulating GR-mediated BDNF expression in the CORT-induced depressive mice model.

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Section: Discussionsupporting

confidence: 82%

Section: Sucrose Preference Test (Spt)mentioning

confidence: 99%

Pedicularis resupinata restores corticosterone-induced depressive-like behaviors in mice via glucocorticoid receptor-mediated BDNF expression

Lim

Han

Lee

2022

Preprint

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“…However, studies on the antidepressant effect of Reg A, a stable characteristic component of Baihe, has not been reported. A large number of studies have used CORT to damage the SH-SY5Y nerve cell model to simulate the pathological changes of depression [46][47][48]. In this study, high concentrations of CORT were used to damage SH-SY5Y cells, which was induced by simulated stress.…”

Section: Discussionmentioning

confidence: 99%

Effects of different drying methods on the chemical constituents of Lilium lancifolium Thunb. based on UHPLC‐MS analysis and antidepressant activity of the main chemical component regaloside A

Yuan

Zhao

et al. 2021

J of Separation Science

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The Lilium lancifolium Thunb. is a herb with multiple functions in both medicine and food in China, and its extracts have shown antidepressant effects. In this study, fresh bulbs of Lilium lancifolium Thunb. were processed to study the effects of different drying processes on changes in its main chemical components. We found that different drying methods can affect the chemical constituents of the herb. Among these components, Regaloside A has been found as the characteristic component. Here, Cell Counting Kit‐8 assay, and Western blotting were used to evaluate the neuroprotective antidepressant effects of Regaloside A. The results showed the cell survival rate was improved, the phosphorylation levels of brain‐derived neurotrophic factor, tyrosine kinase receptor B, phosphatidylinositol 3 kinase, protein kinase B, and mammalian target of rapamycin were increased after Regaloside A treatment. In general, different drying methods have a significant influence on the chemical composition of the herb, and Regaloside A may be the main chemical component of the herb. It can alleviate the damage of corticosterone in SH‐SY5Y cells, and phosphatidylinositol‐3‐kinase/protein kinase B/mammalian target of rapamycin signaling mediated by brain‐derived neurotrophic factor/tyrosine kinase receptor B may play an important role in the neuroprotective antidepressant effects of Regaloside A.

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“…E. japonicum extract (EJE) and imipramine were dissolved in distilled water. To determine the relevant dose of EJE in the current study, we selected the dose for administration according to our previous reports [ 19 , 21 , 22 ]. EJE was treated by oral administration, while the sham and control groups were orally administered with an equal volume of distilled water.…”

Section: Methodsmentioning

confidence: 99%

“…The PAT was conducted as previously described for depression-related cognitive function [ 22 ]. The mice were tested in the GEMINI avoidance system (SD instruments, San Diego, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

Anti-Inflammatory Effects of Asian Fawn Lily (Erythronium japonicum) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice

et al. 2020

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Neuroinflammation is associated with an increased risk of depression. Lipopolysaccharide (LPS) treatment is known to induce pro-inflammatory cytokine secretion and a depressive-like phenotype in mice. Although Erythronium japonicum exhibits various health benefits, the role of E. japonicum extract (EJE) in inflammation-associated depression is unknown. This study aimed to explore the anti-inflammatory effect of EJE on LPS-induced depressive symptoms in mice using the open field test (OFT), passive avoidance test (PAT), tail suspension test (TST), and forced swim test (FST). LPS-treated mice had significantly increased immobility time in the TST and FST, decreased step-through latency time in the PAT, and decreased locomotor activity in the OFT. However, administration of 100 and 300 mg/kg of EJE significantly improved these depressive-like behaviors. EJE also prevented the increase in mRNA levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and monocyte chemoattractant protein-1 (MCP-1), and the decrease in IL-10 levels by inhibiting nuclear factor-κB (NF-κB) subunit p65 phosphorylation. Additionally, LPS-treated mice showed markedly decreased brain-derived neurotrophic factor (BDNF) levels and phosphorylation of phosphoinositide 3-kinase (PI3K) and Akt, while EJE treatment significantly increased these levels in the hippocampus. These results suggest that EJE ameliorated LPS-induced depressive-like behavior by reducing LPS-induced neuroinflammation and activating the BDNF-PI3K/Akt pathway.

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Administration of Asian Herb Bennet (Geum japonicum) Extract Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone

Cited by 20 publications

References 39 publications

Pedicularis resupinata restores corticosterone-induced depressive-like behaviors in mice via glucocorticoid receptor-mediated BDNF expression

Pedicularis resupinata restores corticosterone-induced depressive-like behaviors in mice via glucocorticoid receptor-mediated BDNF expression

Effects of different drying methods on the chemical constituents of Lilium lancifolium Thunb. based on UHPLC‐MS analysis and antidepressant activity of the main chemical component regaloside A

Anti-Inflammatory Effects of Asian Fawn Lily (Erythronium japonicum) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice

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