Administration of Curcuma longa Extract Topically does not Accelerate Skin Excision Wound Closure in Alloxan-Induced Diabetic Mice Model

Berbudi, Afiat; Hasibah, Ulfah Hasna; Faried, Ahmad; Putri, Almahitta Cintami; Hamda, Muhammad Ersyad

doi:10.13005/bpj/1392

Cited by 2 publications

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“…In terms of mode of delivery, oral administration seems to be more effective than topical application. For example, some curcumin gel preparations were proven to be ineffective in improving skin excision healing in alloxan-induced diabetic mice (Berbudi et al 2018).…”

Section: Considerations For the Implementation Of In In Wound Healingmentioning

confidence: 99%

Potentials of Immunonutrition in Wound Healing: A Review

BOON¹,

AZIZAN²,

HASNOL³

et al. 2022

JSKM

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A delayed wound healing process can lead to detrimental complications in chronic wound patients such as tissue necrosis and systemic infections. Application of immunonutrition (IN) in experimental animal models and chronic wound patients has shown promising and improved wound healing processes. IN restores the supply of essential nutrients that are critical for cell growth and tissue repair in the wounded subjects. Several commonly found nutrients in IN formulations include polyunsaturated fatty acids (PUFAs), essential amino acids, trace elements such as zinc and vitamins. Recently, some studies suggested the use of traditionally used herbs like curcumin in IN recipes due to its efficient wound healing properties. The roles and functions of IN in wound healing encompass recruitment of white blood cells, platelets and fibroblasts into the wounded area during the coagulation and inflammation phases, enhancement of fibroblast proliferation, collagen synthesis and neovascularization in the proliferation phase; and lastly, regulation of tissue re-epithelization for wound closure and recovery. In this review, the roles and functions of individual nutrients were deliberately discussed alongside their mechanisms of action in wound healing. This aims to provide a more holistic insight into the potentials of those nutrients when used as part of IN for major wound patients. Despite its remarkable effects in wound healing, several criteria should be considered in an IN formulation: the type and severity of wounds, administration timing and mode of administration, and concoction of immune-boosting nutrients in order to ensure the optimal wound healing effects. Keywords: Wound healing; immunonutrition; PUFAs; amino acids; vitamins

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Section: Considerations For the Implementation Of In In Wound Healingmentioning

confidence: 99%

Potentials of Immunonutrition in Wound Healing: A Review

BOON¹,

AZIZAN²,

HASNOL³

et al. 2022

JSKM

View full text Add to dashboard Cite

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Sappanwood (Caesalpinia sappan) Extract Gel Do Not Heal Skin Excisional Wound on Balb/c Mice

Rezano

Siregar

Maliki

et al. 2019

Biomed. Pharmacol. J.

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Caesalpinia sappan has been studied for its biological activities in the wound healing process. Therefore, this study is conducted to investigate the wound healing activity of sappanwood extract in an excisional wound of Balb/c mice. Animal experiments were designated with, positive control group, negative control group, and three groups of treatment (G1, G2 and G3). The groups consist of povidone iodine ointment, blank gel, 5%, 30%, 90% concentration of sappanwood extract gel, respectively. All groups were applied topically on the surface of the biopsy wound once daily for 10 days. The wounds of the 2nd, 8th and 10th day of treatment were observed and measured. There was a significant difference from each group on day 2, 6 and 10 after wound induction (p=0,001, p=0,001 and p=0,006). The tendency of wound closure happened in positive group control, negative group control and G1. Negative control group showed the highest percentage of wound closure amongst all groups. Meanwhile, in G2 and G3 showed less percentage of closure and healing compared to the others. Despite there is a tendency of ethanolic C. sappan extract gels to the wound healing, administration of C. sappan extract gels topically do not heal the skin excisional wound.

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Administration of Curcuma longa Extract Topically does not Accelerate Skin Excision Wound Closure in Alloxan-Induced Diabetic Mice Model

Cited by 2 publications

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Potentials of Immunonutrition in Wound Healing: A Review

Potentials of Immunonutrition in Wound Healing: A Review

Sappanwood (Caesalpinia sappan) Extract Gel Do Not Heal Skin Excisional Wound on Balb/c Mice

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