Administration of exogenous ghrelin in obese patients with polycystic ovary syndrome: effects on plasma levels of growth hormone, glucose, and insulin

Guido, Maurizio; Romualdi, Daniela; Marinis, Laura De; Porcelli, Teresa; Giuliani, Maddalena; Costantini, Barbara; Lanzone, Antonio

doi:10.1016/j.fertnstert.2006.11.067

Cited by 25 publications

(27 citation statements)

References 46 publications

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“…Three studies have evaluated the effect of ghrelin administration in obesity. One study did not show any change in glucose and insulin concentrations (33), while two studies reported an increase in glucose concentration with a slight decrease in insulin levels (9,21). These results are not in accordance with the present findings that show a highly significant decrease in insulin concentrations without a reciprocal increase in glucose concentrations.…”

Section: Discussioncontrasting

confidence: 93%

“…Since insulin displays an exactly opposite meal-related pattern, the interaction between insulin and ghrelin has been extensively studied. In general, it is assumed that insulin has a negative effect on ghrelin concentrations (18,19), whereas administration of AG results in insulin resistance (6,(20)(21)(22). On the other hand, the effect of UAG on insulin metabolism is still a matter of debate.…”

Section: Introductionmentioning

confidence: 99%

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Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes

Kiewiet

Aken

Weerd

et al. 2009

European Journal of Endocrinology

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Objective: To investigate the effects of unacylated ghrelin (UAG) and co-administration of acylated ghrelin (AG) and UAG in morbid obesity, a condition characterized by insulin resistance and low GH levels. Design and method: Eight morbidly obese non-diabetic subjects were treated with either UAG 200 mg, UAG 100 mg in combination with AG 100 mg (Comb) or placebo in three episodes of 4 consecutive days in a double-blind randomized crossover design. Study medication was administered as daily single i.v. bolus injections at 0900 h after an overnight fast. At 1000 h, a standardized meal was served. Glucose, insulin, GH, free fatty acids (FFA) and ghrelin were measured up to 4 h after administration. Results: Insulin concentrations significantly decreased after acute administration of Comb only, reaching a minimum at 20 min: 58.2G3.9% of baseline versus 88.7G7.2 and 92.7G2.6% after administration of placebo and UAG respectively (P!0.01). After 1 h, insulin concentration had returned to baseline. Glucose concentrations did not change after Comb. However, UAG administration alone did not change glucose, insulin, FFA or GH levels. Conclusion: Co-administration of AG and UAG as a single i.v. bolus injection causes a significant decrease in insulin concentration in non-diabetic subjects suffering from morbid obesity. Since glucose concentration did not change in the first hour after Comb administration, our data suggest a strong improvement in insulin sensitivity. These findings warrant studies in which UAG with or without AG is administered for a longer period of time. Administration of a single bolus injection of UAG did not influence glucose and insulin metabolism.

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Section: Discussioncontrasting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes

Kiewiet

Aken

Weerd

et al. 2009

European Journal of Endocrinology

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“…(1,(4)(5)(6). Several in vitro and in vivo studies have shown that ghrelin may regulate insulin and glucose metabolism (7)(8)(9)(10)(11). Ghrelin was shown to inhibit insulin secretion from pancreatic islets in rodents (9).…”

Section: Introductionmentioning

confidence: 99%

“…Intravenous administration of ghrelin to healthy young men impaired insulin sensitivity (10). In obese women with polycystic ovary syndrome, ghrelin induced a significant decrease in insulin concentrations; an increase (though not significant) in glucose levels was also observed (11). Earlier studies on ghrelin and energy balance and metabolism were performed by total ghrelin assays.…”

Section: Introductionmentioning

confidence: 99%

Acylated and nonacylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome

Pacifico

Poggiogalle

Costantino

et al. 2009

European Journal of Endocrinology

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Background: Ghrelin, a peptide mainly derived from the stomach, plays a pivotal role in the regulation of food intake, energy metabolism, and storage, as well as in insulin sensitivity. Ghrelin circulates in acylated (A-Ghr) and nonacylated (NA-Ghr) forms, and their potential differential associations with insulin resistance (IR) in childhood obesity remain undefined. Objective: We investigated the associations of ghrelin forms with IR in normal weight and obese children and the impact of metabolic syndrome (MS) on their plasma values. Design: A total of 210 children in four subgroups of normal weight/obese children with and without components of MS were studied. Fasting blood glucose, insulin, lipid profile, and acylated and total ghrelin were examined. IR was determined by a homeostasis model assessment (HOMA) of IR. Results: In the entire population, plasma insulin and HOMA-IR were associated negatively with T-Ghr and NA-Ghr, but positively with the ratio of A/NA-Ghr after adjustment for age, gender, and Tanner stage. Obese metabolically abnormal children had lower T-Ghr and NA-Ghr, but comparable A-Ghr and a higher A/NA-Ghr ratio than obese metabolically normal subjects. Compared with lean healthy children, lean metabolically abnormal subjects had higher A-Ghr and the A/NA-Ghr ratio, but comparable T-Ghr and NA-Ghr. A multiple regression analysis showed that A-Ghr and the A/NA-Ghr ratios were positively associated with HOMA-IR, independent of age, gender, Tanner stage, and body mass index (or waist circumference) and other components of MS. Conclusions: A-Ghr excess may negatively modulate insulin action in obese and nonobese children, and may contribute to the association of IR and MS.

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“…Στο σύνδροµο αυτό, τα δεδοµένα είναι αντιφατικά. Συγκεκριµένα, έχουν αναφερθεί τιµές γκρελίνης χαµηλότερες της οµάδας µαρτύρων (Panidis et al, 2005;Guido et al, 2007;Barber et al, 2008), όπως και τιµές υψηλότερες (Wasko et al, 2004) ή τιµές παρόµοιες µε την οµάδα µαρτύρων (Orio et al, 2003). Mία από τις πρώτες µελέτες έδειξε ότι οι τιµές της γκρελίνης στο πλάσµα των γυναικών µε το σύνδροµο των πολυκυστιών ωοθηκών έιναι χαµηλότερες στις παχύσαρκες γυναίκες σε σύγκριση µε παχύσαρκες χωρίς το σύνδροµο αυτό (Pagotto et al, 2002).…”

Section: επίδραση στις ωοθήκεςunclassified

Ο ρόλος της ghrelin στην έκκριση της προλακτίνης και των γοναδοτροφινών ορμονών σε γυναίκες

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Administration of exogenous ghrelin in obese patients with polycystic ovary syndrome: effects on plasma levels of growth hormone, glucose, and insulin

Cited by 25 publications

References 46 publications

Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes

Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes

Acylated and nonacylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome

Ο ρόλος της ghrelin στην έκκριση της προλακτίνης και των γοναδοτροφινών ορμονών σε γυναίκες

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