Administration of Huperzine A exerts antidepressant-like activity in a rat model of post-stroke depression

Du, Yuan; Liang, Haiyue; Zhang, Leiming; Fu, Fenghua

doi:10.1016/j.pbb.2017.06.002

Cited by 24 publications

(14 citation statements)

References 30 publications

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“…We determined the levels of NE, DA and 5‐HT in mouse hippocampus using ELISA kits. In this study, decreased levels of NE, DA and 5‐HT in the model group were observed, which was consistent with previous reports (Du, Liang, Zhang, & Fu, ). Our results also showed that NE, DA and 5‐HT in the Flu and YXST groups showed an upward trend to normal levels.…”

Section: Discussionsupporting

confidence: 93%

Metabolic analysis of the antidepressive effects of Yangxinshi Tablet in a vascular depression model in mice

Zhang

Zhao³

et al. 2017

Biomedical Chromatography

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In recent years, vascular depression has become the focus of international attention. Yangxinshi Tablet (YXST) is usually used in cthe linic for the treatment of arrhythmia and heart failure, but we found that it also has antidepressive effects. The objective of the study was to identify biomarkers related to vascular depression in hippocampus and explore the antidepressive effects of YXST on the mouse model. Untargeted metabolomics based on UHPLC-Q-TOF/MS was applied to identify significantly differential biomarkers between the model group and control group. Unsupervised principal component analysis (PCA) was used to scan the tendency of groups and partial least squares-discriminant analysis (PLS-DA) to distinguish between the vascular depressive mice and the sham. PCA stores showed clear differences in metabolism between the vascular depressive mice and sham groups. The PLS-DA model exhibited 38 metabolites as the biomarkers to distinguish the vascular depressive mice and the sham. Further, YXST significantly regulated 22 metabolites to normal levels. The results suggested that YXST has a comprehensive antidepressive effect on vascular depression via regulation of multiple metabolic pathways including amino acid, the tricarboxylic acid cycle and phosphoglyceride metabolisms. These findings provide insight into the pathophysiological mechanism underlying vascular depression and the mechanism of YXST.

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Section: Discussionsupporting

confidence: 93%

Metabolic analysis of the antidepressive effects of Yangxinshi Tablet in a vascular depression model in mice

Zhang

Zhao³

et al. 2017

Biomedical Chromatography

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“…In our study, we found that PSD rats exhibited both neurological impairments such as reduced asymmetry, strength, and decreased walking time, as well as impaired memory with MWMT test. BWT is a behavior test on assessing motor coordination after a stroke, and the CT and FGFT tests are behavior tests on assessing subjects for motor impairments [4,27,28]. e impairment of neurological and cognitive functions was observed in our PSD rat model, and treatment with JY significantly decreased the impairments, including improving grip force, decreasing asymmetry and beam crossing time.…”

Section: Discussionmentioning

confidence: 92%

Jieyu Anshen Granule, a Chinese Herbal Formulation, Exerts Effects on Poststroke Depression in Rats

Ruan²,

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Jieyu Anshen granule (JY) is a traditional Chinese medicine formula for treating depression and anxiety. e aim of the study was to observe the effects of JY on poststroke depression (PSD) and investigate the underlying mechanism. PSD rat model was developed by middle cerebral artery occlusion following chronic unpredictable mild stress in conjunction with isolation rearing. We performed behavioral tests, Western blot, ELISA, and BrdU/NeuN staining. Treatment with JY showed significant antidepressant effect in open-field and sucrose preference tests, as well as significant improvement in beam-walking, cylinder, grip strength, and water maze tests. In addition, treatment with JY could restore the levels of neurotransmitters and decrease the levels of hormone and inflammation cytokines in serum and brain. Treatment with JY also showed significant regulation in the expression of neurotransmitter receptors and NF-κB/IκB-α signaling in the prefrontal cortex and hippocampus. Moreover, the numbers of newborn neurons in the hippocampus were increased by treatment with JY. Our results suggest that JY could ameliorate PSD and improve the neurological and cognitive functions. e antidepressive effect may be associated with the modulation of JY on monoamine system, neuroendocrine, neuroinflammation, and neurogenesis.

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“…The biosynthesis of ACh was not changed, which was shown by unaltered choline levels or choline acetyltransferase level in any region of rat's brain. 26 This rise was sustained for 6 h. Systemic HupA considerably enhanced ACh levels above baseline at doses of 0.1, 0.3 and 0.5 mg/kg by 54%, 129% and 220% respectively. NE and DA levels were enhanced more than 100%after administration of the 0.3 and 0.5 mg/kg doses.…”

Section: Effects On Neurotransmittersmentioning

confidence: 87%

Huperzinea: Pharmacological and Therapeutic Potential

Dubey¹,

Ahmad²,

Sharma³

et al. 2020

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Introduction: Huperzine A (HupA) is derived from a club moss (Huperzia serrata). It is a potent and reversible inhibitor of acetyl cholinesterase (AChE). Chemically, it is a sesquiterpene alkaloid. It has been used for the treatment of swelling, fever and blood disorders for centuries in China. Methodology: The literature available on Huperzine was thoroughly studied. It has shown much beneficial effect since ages. It is a established Nootropic agent and widely used in the treatment of Alzheimer's disease. The plant has shown promising results in vivo and in vitro studies. Results and Conclusion: The present review highlights the pharmacological potential of Huperzine with its pharmacokinetic and pharmacokinetic studies and it's rational for future prospective.

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Administration of Huperzine A exerts antidepressant-like activity in a rat model of post-stroke depression

Cited by 24 publications

References 30 publications

Metabolic analysis of the antidepressive effects of Yangxinshi Tablet in a vascular depression model in mice

Metabolic analysis of the antidepressive effects of Yangxinshi Tablet in a vascular depression model in mice

Jieyu Anshen Granule, a Chinese Herbal Formulation, Exerts Effects on Poststroke Depression in Rats

Huperzinea: Pharmacological and Therapeutic Potential

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