Huperzinea: Pharmacological and Therapeutic Potential

Abstract

Introduction: Huperzine A (HupA) is derived from a club moss (Huperzia serrata). It is a potent and reversible inhibitor of acetyl cholinesterase (AChE). Chemically, it is a sesquiterpene alkaloid. It has been used for the treatment of swelling, fever and blood disorders for centuries in China. Methodology: The literature available on Huperzine was thoroughly studied. It has shown much beneficial effect since ages. It is a established Nootropic agent and widely used in the treatment of Alzheimer's disease. The plant has shown promising results in vivo and in vitro studies. Results and Conclusion: The present review highlights the pharmacological potential of Huperzine with its pharmacokinetic and pharmacokinetic studies and it's rational for future prospective.

Protective Effect of Rutin on Cognition Impairment Caused by Levetiracetam.

“…Rutin is a member of the flavonoid family, and many of its members have different effects on the cholinergic system. PIM is a member of the pyrrolidone's group, the majority of whose members influence the cholinergic system (8,11,24). PIM and rutin decreased the brain's AChE activity in our investigation.…”

“…Higher dosages of PIM have demonstrated a strong antiepileptic impact against ICES (26) as well as substantial nootropic effects on the MES model (7). Another well-known flavonoid is rutin, which has nootropic properties (19)(20)(21)(22)(23)(24)(25).Therefore, the goal of this investigation was to convince the effect. Thus in this study it was intended to persuade the effect of co administration of PIM and Rutin with a clinically established AED in antiepileptic therapy.…”