Administration of<i>Nigella sativa</i>during neonatal and juvenile growth period improved liver function of propylthiouracil-induced hypothyroid rats

Hosseini, Mahmoud; Ghasemi, Simagol; Hadjzadeh, Mosa Al Reza; Ghorbani, Ahmad; Aghili, Sasan; Aghaei, Azita; Soukhtanloo, Mohammad; Beheshti, Farimah

doi:10.1080/14767058.2018.1500540

Cited by 5 publications

(3 citation statements)

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“…44 An increase in the activities of enzymes including AST, ALT and Alk-P reflects hepatic dysfunction. 45,46 In addition, there are no remarkable differences between F3D (100 and 300 mg/kg) and control group into the liver parameters. Although, the administration of F3D (100 and 300 mg/kg) to the HFD rats reverted the values of liver dysfunction indices back to normal.…”

Section: Effect Of F3d On Serum Biochemical Parametersmentioning

confidence: 88%

Effect of Opuntia dejecta (Salm-Dyck) flowers in liver of fructose-fed rats: Biochemicals, enzymatic and histological studies

et al. 2021

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Phytochemical composition and antioxidant activity of flowers decoction at post-flowering stage (F3D) of Opuntia dejecta were determined. The obtained findings demonstrate that F3D has a marked antioxidant activity in all tested assays. Furthermore, the present study was designed to test the protective activity of F3D against induced Diabetes type 2 (DT2) in male rats. Those metabolic syndromes were induced by a high-fructose diet (HFD) (10% fructose solution) for a period of 20 weeks. F3D was administered orally (100 and 300 mg/kg body weight) daily for the last 4 weeks. Metformin (150 mg/kg body weight) was used as a standard drug and administrated orally for the last 4 weeks. The results showed a significant increase in blood glucose, triglycerides and hepatic markers (ALAT, ASAT and ALK-P) in HFD group. A significant increase in hepatic TBARS and a significant decrease in SOD, CAT and GPX were observed in fructose fed rats compared to control group. Administration of F3D showed a protective effect in biochemical and oxidative stress parameters measured in this study. Also, oral administration of F3D restored the histological architecture of rat liver in comparison with rats fed HFD. In conclusion, F3D attenuated hepatic oxidative stress in fructose-fed rats.

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Section: Effect Of F3d On Serum Biochemical Parametersmentioning

confidence: 88%

Effect of Opuntia dejecta (Salm-Dyck) flowers in liver of fructose-fed rats: Biochemicals, enzymatic and histological studies

et al. 2021

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“…Oxidative stress causing lipid peroxidation is one of the major causes of hepatic disease [ 152 , 153 ]. Studies demonstrate that toxicants, such as carbon tetrachloride, arsenic, and acetaminophen induce cellular oxidative stress leading to lipid peroxidation as evidenced by the production of high MDA level in rat models [ 154 , 155 , 156 , 157 , 158 ]. Lipid peroxidation causes the damage of hepatocytes, which is characterized by histopathological changes of liver and high blood levels of hepatic enzymes (ALT and AST).…”

Section: Benefits Of Black Cumin On Human Health and Disease Conditionsmentioning

confidence: 99%

“…Lipid peroxidation causes the damage of hepatocytes, which is characterized by histopathological changes of liver and high blood levels of hepatic enzymes (ALT and AST). However, supplementation of black cumin extract or its active components stimulates the cellular antioxidant systems and increase the activities of SOD, CAT, and GPx, and level of GSH, thereby reducing the oxidative stress and ER stress (reduced activity of GRP78, CHOP, ATF6, ATF4, XBP1), lowering lipid peroxidation, and improving the longevity of experimental animals [ 136 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 ].…”

Section: Benefits Of Black Cumin On Human Health and Disease Conditionsmentioning

confidence: 99%

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

et al. 2021

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Mounting evidence support the potential benefits of functional foods or nutraceuticals for human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical herb with a wide array of health benefits, has attracted growing interest from health-conscious individuals, the scientific community, and pharmaceutical industries. The pleiotropic pharmacological effects of black cumin, and its main bioactive component thymoquinone (TQ), have been manifested by their ability to attenuate oxidative stress and inflammation, and to promote immunity, cell survival, and energy metabolism, which underlie diverse health benefits, including protection against metabolic, cardiovascular, digestive, hepatic, renal, respiratory, reproductive, and neurological disorders, cancer, and so on. Furthermore, black cumin acts as an antidote, mitigating various toxicities and drug-induced side effects. Despite significant advances in pharmacological benefits, this miracle herb and its active components are still far from their clinical application. This review begins with highlighting the research trends in black cumin and revisiting phytochemical profiles. Subsequently, pharmacological attributes and health benefits of black cumin and TQ are critically reviewed. We overview molecular pharmacology to gain insight into the underlying mechanism of health benefits. Issues related to pharmacokinetic herb–drug interactions, drug delivery, and safety are also addressed. Identifying knowledge gaps, our current effort will direct future research to advance potential applications of black cumin and TQ in health and diseases.

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Nigella sativa L.: Uses in traditional and contemporary medicines – An overview

Majeed

Muhammad

Ahmad

et al. 2021

Acta Ecologica Sinica

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Administration ofNigella sativaduring neonatal and juvenile growth period improved liver function of propylthiouracil-induced hypothyroid rats

Abstract: The results of this study demonstrated that administration of NS hydroalcoholic extract in the neonatal and juvenile growth period has an improving effect on the liver function of PTU- induced hypothyroid rats.

Cited by 5 publications

References 49 publications

Effect of Opuntia dejecta (Salm-Dyck) flowers in liver of fructose-fed rats: Biochemicals, enzymatic and histological studies

Effect of Opuntia dejecta (Salm-Dyck) flowers in liver of fructose-fed rats: Biochemicals, enzymatic and histological studies

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

Nigella sativa L.: Uses in traditional and contemporary medicines – An overview

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