Administration of Lactobacillus paracasei HB89 mitigates PM2.5-induced enhancement of inflammation and allergic airway response in murine asthma model

Lin, Ching-Hung; Tseng, Chia-Yi; Chao, Ming-Wei

doi:10.1371/journal.pone.0243062

Cited by 16 publications

(13 citation statements)

References 37 publications

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“…According to reports in recent years, the most commonly studied probiotics are Lactobacillus and Bifidobacterium . Their protective effects in animal models of respiratory virus infection have been well established 29 . For example, orally administered Lactobacillus , including Lactobacillus casei , Lactobacillus rhamnosus , Lactobacillus gasseri , Lactobacillus pentosus , Lactobacillus plantarum , Lactobacillus brevis , Lactobacillus johnsonii , Bifidobacterium breve 155 , and Bifidobacterium longum 180 , protected all the mice from influenza-virus-induced pathology and mortality.…”

Section: Discussionmentioning

confidence: 99%

Intestinal bacteria flora changes in patients with Mycoplasma pneumoniae pneumonia with or without wheezing

Jiang

Bao

Zhao

et al. 2022

Sci Rep

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Mycoplasma pneumoniae (MP) infection is a common cause of community-acquired pneumonia in children. Furthermore, many children with Mycoplasma pneumoniae pneumonia (MPP) have recurrent wheezing and reduced small airway function after their clinical symptoms have resolved, eventually leading to asthma. MPP can trigger immune disorders and systemic inflammatory responses. Hence, the intestine is the largest immune organ of the body. Therefore, we sought to investigate whether the alteration of intestinal flora is correlated with the development of wheezing in children with MPP. We collected 30 healthy children as group A, 50 children with nonwheezing MPP as group B, and 50 children with wheezing MPP as group C. We found that the percentage of eosinophil cells (EC) was significantly higher in group C than that in group B for routine blood tests and serum inflammatory factors. The serum cytokines, including IL-4, IL-17, TNF-α, and TGF-β, were significantly higher in group C than in group B. In addition, the level of IL-10 was significantly lower in group C than in group B. The distribution characteristics of intestinal flora strains in children with MPP were detected by sequencing of 16S rRNA gene amplicon sequencing. There were differences in the abundance of intestinal flora between children with MPP and healthy children, with lower abundance of Ruminococcus flavefaciens, Clostridium butyricum, Lactobacillus, and Bifidobacterium in the intestine of children with MPP compared to healthy children. The abundance of Ruminococcus flavefaciens and Clostridium butyricum was significantly lower in the intestine of children with wheezing MPP compared to children without wheezing MPP. In the correlation analysis between children with MPP and inflammatory factors, Ruminococcus flavefaciens was found to be negatively correlated with IL-17. Clostridium butyricum was negatively correlated with L-4, IL-17, TNF-α, and TGF-β; however, it positively correlated with IL-10. Thus, it was concluded that alterations in intestinal flora play a crucial role in the immune response to MPP, where a significant decline in intestinal Ruminococcus flavefaciens and Clostridium butyricum leads to an exacerbation of the inflammatory responses, which may promote the development of children with wheezing MPP.

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Section: Discussionmentioning

confidence: 99%

Intestinal bacteria flora changes in patients with Mycoplasma pneumoniae pneumonia with or without wheezing

Jiang

Bao

Zhao

et al. 2022

Sci Rep

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“…Bacteria can also be used as a therapeutic tool, and this applies also to PM-induced lung allergic inflammation. Lin et al (2020), showed that Lactobacillus paracasei decreased the type 2 allergic response induced by OVA and PM, by decreasing the IgE levels, cytokines IL-4, IL-5, IL-13, and histamine [127]. This was confirmed by Nam et al (2020), who also showed that probiotics can protect against PM-induced airway inflammation [128].…”

Section: Particulate Mattermentioning

confidence: 98%

Air Pollution and the Airways: Lessons from a Century of Human Urbanization

et al. 2021

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Since the industrial revolution, air pollution has become a major problem causing several health problems involving the airways as well as the cardiovascular, reproductive, or neurological system. According to the WHO, about 3.6 million deaths every year are related to inhalation of polluted air, specifically due to pulmonary diseases. Polluted air first encounters the airways, which are a major human defense mechanism to reduce the risk of this aggressor. Air pollution consists of a mixture of potentially harmful compounds such as particulate matter, ozone, carbon monoxide, volatile organic compounds, and heavy metals, each having its own effects on the human body. In the last decades, a lot of research investigating the underlying risks and effects of air pollution and/or its specific compounds on the airways, has been performed, involving both in vivo and in vitro experiments. The goal of this review is to give an overview of the recent data on the effects of air pollution on healthy and diseased airways or models of airway disease, such as asthma or chronic obstructive pulmonary disease. Therefore, we focused on studies involving pollution and airway symptoms and/or damage both in mice and humans.

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“…Recent studies were mostly focused on probiotics, of which Lactobacillus and Bifidobacteria were the most common. The protective effects of these two bacteria in viral respiratory tract infections have been verified in animal models [33]. For example, oral administration of Lactobacillus, such as Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus gasseri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus brevis, Lactobacillus johnsonni, Bifidobacterium breve 155, or Bifidobacterium longum 180 could protect mice from flu virus-induced pathology and mortality.…”

Section: Respiratory Tract Infection and Gut Microorganismsmentioning

confidence: 99%

Characteristics of gut microbiota in 100 children with mycoplasma pneumonia in China

Bao¹,

Zhao²,

CHen³

et al. 2021

Preprint

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Exploring the "lung-intestine"axis of gut microbiota is a hot spot in recent years. There have been few studies on the correlation between gut microbiota and asthma and allergies, of which gut microbiota-mediated molecular regulation of the pathogenesis of infectious pathogens is a blind area. Therefore, we investigated gut microecological changes in MPP patients and the gut microecological characteristics of wheezing MPP pediatric patients.30 healthy children, 50 nonwheezing MPP pediatric patients, and 50 wheezing MPP pediatric patients were collected. 16srDNA gene sequencing results showed that there are differences in gut microbiota abundances between MPP pediatric patients and healthy children. Quantitative real-time polymerase chain reaction (QRT-PCR) validation showed that the abundances of Ruminococcus flavefaciens, Clostridium butyricum, Lactobacillus, and Bifidobacterium in the guts of MPP children decreased compared with healthy children. Compared with nonwheezing MPP children, the abundances of Ruminococcus flavefaciens and Clostridium butyricum were significantly decreased in the guts of wheezing MPP children. This indicates that Ruminococcus flavefaciens and Clostridium butyricum are significantly decreased in nonwheezing MPP children and could be potential risk factors for wheezing in MPP children.

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Administration of Lactobacillus paracasei HB89 mitigates PM2.5-induced enhancement of inflammation and allergic airway response in murine asthma model

Cited by 16 publications

References 37 publications

Intestinal bacteria flora changes in patients with Mycoplasma pneumoniae pneumonia with or without wheezing

Intestinal bacteria flora changes in patients with Mycoplasma pneumoniae pneumonia with or without wheezing

Air Pollution and the Airways: Lessons from a Century of Human Urbanization

Characteristics of gut microbiota in 100 children with mycoplasma pneumonia in China

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