Administration of Lactobacillus plantarum 299v reduces side effects of external radiation on colon anastomotic healing in rats

Liu, Qing; Nobaek, Soran; Adawi, Diya; Mao, Yilei; Månsson, Peter; Blomquist, Peter; Molin, Göran; Ekelund, Mats; Jeppsson, Bengt

doi:10.1016/s0016-5085(00)80079-7

Cited by 9 publications

(11 citation statements)

References 18 publications

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“…To reduce complications, like diarrhoea, retarded healing, and mucosal atrophy, after this treatment enteral feeding of L. plantarum 299v in rats was examined and found to reduce inflammatory reactions and increase healing of the wound (Liu et al, 2001) (Table 3). However, patients who were scheduled for intestinal surgery were asked to consume L. plantarum a week prior to the intervention.…”

Section: Article In Pressmentioning

confidence: 99%

Lactobacillus plantarum—survival, functional and potential probiotic properties in the human intestinal tract

Vries

Vaughan

Kleerebezem

et al. 2006

International Dairy Journal

435

279

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Section: Article In Pressmentioning

confidence: 99%

Lactobacillus plantarum—survival, functional and potential probiotic properties in the human intestinal tract

Vries

Vaughan

Kleerebezem

et al. 2006

International Dairy Journal

435

279

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“…Species of the genus Lactobacillus are common commensals in the gastrointestinal tract (GIT) of mammals and are potentially probiotic organisms that contribute to the health of the host (Marco et al , 2006). For example, Lactobacillus plantarum 299v has been shown to prevent intestinal inflammation in experimental models (Liu et al , 2001) and to have a beneficial effect in patients suffering from irritable bowel syndrome (Niedzielin et al , 2001).…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of cell surface-associated proteins from probioticLactobacillus plantarum

Beck

Madsen

Glenting

et al. 2009

FEMS Microbiology Letters

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In the present study, we used a proteomic approach to identify surface-associated proteins from the probiotic bacterium Lactobacillus plantarum 299v. Proteins were extracted from the cell surface using a mild wash in phosphate buffer and analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis. Gel bands were excised and in-gel digested with trypsin. The resulting peptides were analysed by capillary-LC-ESI-MS/MS. The peptide sequences were used for a database search and allowed identification of a total of 29 proteins, many of which could potentially be involved in the action of probiotics in the gastrointestinal tract. The results provide the basis for future studies on the molecular mechanisms of probiotics.

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“…Radiation therapy is usually associated with several complications, including diarrhea, retarded anastomotic healing and mucosal atrophy (Liu et al ., ). In the present study, none of the animals were found to be dead and no clinical sign was observed during the 28‐day study period.…”

Section: Discussionmentioning

confidence: 97%

Extended acute toxicity study of ¹⁸⁸Re‐liposome in Rats

Liu

Tsai

et al. 2012

J of Applied Toxicology

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Liposomes can selectively target cancer sites and carry payloads, thereby improving diagnostic and therapeutic effectiveness as well as reducing toxicity. To evaluate therapeutic strategies, it is essential to use animal models reflecting important safety aspects before clinical application. As our previous study found that a high dosage (185 of MBq) of (188) Re-N,N-bis (2-mercaptoethyl)-N',N'-diethylethylenediamine-labeled pegylated liposomes ((188) Re-liposome) induced a decrease in white blood cell (WBC) count in Sprague-Dawley rats 7 days postinjection, the objective of the present study was to investigate extended acute radiotoxicity of (188) Re-liposome. Rats were administered via intravenous (i.v.) injection with (188) Re-liposome (185, 55.5 and 18.5 MBq), normal saline as a blank control or non-radioactive liposome as a vehicle control. Mortality, clinical signs, food consumption, body weights, urinary, biochemical and hematological analyzes were examined. In addition, gross necropsy and histopathological examinations were also performed at the end of the follow-up period. None of the rats died and no clinical sign was observed during the 28-day study period. Only male rats receiving (188) Re-liposome at a high dosage (185 MBq) displayed a slight weight loss compared with the control rats. In both male and female rats, the WBC counts of both high-dose and medium-dose (55.5 MBq) groups reduced significantly 7 days postinjection, but recovered to the normal range on Study Day 29. There was no significant difference in urinary analyzes, biochemical parameters and histopathological assessments between the (188) Re-liposome-treated and control groups. The information generated from the present study on extended acute toxicity of (188) Re-liposome will serve as a safety reference for radiopharmaceuticals in early-phase clinical trials.

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Administration of Lactobacillus plantarum 299v reduces side effects of external radiation on colon anastomotic healing in rats

Cited by 9 publications

References 18 publications

Lactobacillus plantarum—survival, functional and potential probiotic properties in the human intestinal tract

Lactobacillus plantarum—survival, functional and potential probiotic properties in the human intestinal tract

Proteomic analysis of cell surface-associated proteins from probioticLactobacillus plantarum

Extended acute toxicity study of ¹⁸⁸Re‐liposome in Rats

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Administration of Lactobacillus plantarum 299v reduces side effects of external radiation on colon anastomotic healing in rats

Cited by 9 publications

References 18 publications

Lactobacillus plantarum—survival, functional and potential probiotic properties in the human intestinal tract

Lactobacillus plantarum—survival, functional and potential probiotic properties in the human intestinal tract

Proteomic analysis of cell surface-associated proteins from probioticLactobacillus plantarum

Extended acute toxicity study of 188Re‐liposome in Rats

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Extended acute toxicity study of ¹⁸⁸Re‐liposome in Rats