Administration of Vitamin D₃ and E supplements reduces neuronal loss‏ and oxidative stress in a model of rats with Alzheimer’s disease

Neuroprotective Effect of Antioxidants in the Brain

“…Increased dichlorofluorescein (DCF) fluorescence and thiobarbiturate reactive substance (TBARS) levels were decreased by drug treatment ( Figure 4 ). In AD patients, long-term administration of vitamin D and E alone or in combination could inhibit morphological changes of neurons and improve learning and memory [ 167 ]. Vitamin E prevented the memory impairment associated with post-traumatic stress disorder (PTSD)-like behavior in rats.…”

Nanonaringenin and Vitamin E Ameliorate Some Behavioral, Biochemical, and Brain Tissue Alterations Induced by Nicotine in Rats

“…NNG has successfully ameliorated learning deficits mediated by inhibition of brain AchE activity [26] because it has an antiapoptotic effect [93]. Vitamin E alone was reported to attenuate the effect of hypoxia on the learning of rats [94,95] and improved learning memory deficit [96]. On the contrary, no improvement or impairments in cognition were found following the administration of vitamin E [97][98][99].…”

An Investigation into the Interaction between Double Hydroxide-Based Antioxidant Benzophenone Derivatives and Cyclooxygenase 2

“…The stock solutions were diluted with FBS free DMEM to different target concentrations (DMSO concentrations ≤ 0.5% v:v). Cells (100 µL, 2 × 10 5 cells•mL −1 ) were seeded on 96-well plates and cultured for 24 h. The medium was then replaced with fresh media containing H 2 O 2 with different concentrations (0, 100, 200, 300, 400, 500, and 600 µmol•L −1 in FBS free DMEM) and compound SC2 (50,40,30,20, 10 µmol•L −1 ), which were transferred to the incubator and cultured for additional time (2, 4, and 6 h). The medium was then replaced with 100 µL of FBS free DMEM and MTT (10 µL, 5 mg•mL −1 in PBS) and after 4 h the medium was replaced with DMSO (100 µL).…”

“…Among these properties, anti-inflammatory and antioxidant activities are highlighted. Because extensive oxidative stress and inflammation contribute to the occurrence of molecular and cellular damage directly or indirectly, there is an increased risk for other complications, including sclerosis as well as heart, respiratory and neurodegenerative diseases [19,20]. It is important to mention that dihydroxybenzenes exhibit a wide spectrum of anti-inflammatory and antioxidant activities owing to the free radicals blocking ability of phenolic hydroxyl groups [12,21].…”