Administration Routes for Nano Drugs and Characterization of Nano Drug Loading

Nikolić, Vesna; Ilić‐Stojanović, Snežana; Petrović, Slađana; Tačić, Ana; Nikolić, Ljubiša

doi:10.1016/b978-0-12-814031-4.00021-0

Cited by 18 publications

(11 citation statements)

References 175 publications

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“…50 Different administration routes have been explored, such as ophthalmic, pulmonary, dermal, transdermal, nasal, and parenteral, among others. 51 The decision of best administration route depends on NP composition, as well as the pathology. The transdermal, nasal, and parenteral administration routes could be considered for Cur-PCL NP.…”

Section: Np Decrease Ros Expressionmentioning

confidence: 99%

Curcumin-loaded poly-ε-caprolactone nanoparticles show antioxidant and cytoprotective effects in the presence of reactive oxygen species

Prado-Audelo

Rodríguez‐Martínez

Martínez-López

et al. 2020

Journal of Bioactive and Compatible Polymers

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Interest in novel delivery systems that improve the cytoprotective and antioxidant effects of natural drugs has been explored recently due to the increase in the incidence of chronic diseases in which oxidation mechanisms are involved. Curcumin is a phenolic compound recently shown to be clinically significant due to its anti-inflammatory, anticancer, and antioxidant properties. However, this molecule possesses a low bioavailability and a high degradation rate in the presence of light. Therefore, we prepared nanoparticles of poly-ε-caprolactone and Pluronic® F-68 as a stabilizer and loaded these with curcumin (Cur–PCL nanoparticles) for antioxidant and cytoprotective applications. The nanoparticles did not induce cell death, but they did reduce cell proliferation without affecting cell migration and cell adhesion. Interestingly, Cur–PCL and poly-ε-caprolactone nanoparticles reduced the oxidative stress induced by hydrogen peroxide and presented a cytoprotective effect. Remarkably, poly-ε-caprolactone nanoparticles showed a decrement of 30% in reactive oxygen species presence compared to the positive control. The decrease of reactive oxygen species derived from the administration of poly-ε-caprolactone nanoparticles could be attributed to the presence of Pluronic® F-68. Taken together, these data indicated that these nanoparticles might have a clinical application in disorders related to reactive oxygen species formation.

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Section: Np Decrease Ros Expressionmentioning

confidence: 99%

Curcumin-loaded poly-ε-caprolactone nanoparticles show antioxidant and cytoprotective effects in the presence of reactive oxygen species

Prado-Audelo

Rodríguez‐Martínez

Martínez-López

et al. 2020

Journal of Bioactive and Compatible Polymers

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“…Hydrogels are classified on following basis as shown in figure 3 (Ahmed, 2015;Yang, Chu, & Fix, 2002;Zhai, Li, Yi, & Ha, 2000) According to Source These hydrogels are linked by physical or non-covalent interaction like hydrogen bonding through mutual bonding of chains of polymers (Nikolić, Ilić-Stojanović, Petrović, Tačić, & Nikolić, 2019).…”

Section: Classification Of Hydrogelsmentioning

confidence: 99%

Hydrogels as Controlled Drug Delivery System: A Brief Review of Properties Classification and Synthesis

Shoukat

Noreen

Asghar

2020

GPSR

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Hyrogels are cariers of novel drug delievry system and these polymeric network have ability to hold large amount of water but they do not dissolve in water .These polymeric network may be crosslinked either through chemical or physical crosslinking method. Without changing their three dimensional structure hydrogels undergo the swelling mechanism Hydrogels are used as drug delivery carriers because of their distinctive properties. They have three dimensional configurations and have water soluble cross linked network of polymers .Hydrogels have porous structure and by changing the cross linker concentration we can modify their affinity for water. Because of their unique properties these are used for various medical purposes like cellular immobilization , tissue engineering ,diagnostics and regenerative medicines.

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“…There are different routes of administration to the body for nanodrug delivery systems, such as oral, nasal, ophthalmic, parenteral, dermal, transdermal, pulmonary, and others. 8 One of the most preferred methods of administration in both conventional and nanodrug delivery systems is oral administration. Oral drug administration is simple, noninvasive, and painless, and therefore often has high patient compliance.…”

Section: Introductionmentioning

confidence: 99%

Nano Spray-Dried Drugs for Oral Administration: A Review

Öztürk

Arpagaus

2021

ASSAY and Drug Development Technologies

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Spray drying is an important technology that is fast, simple, reproducible, and scalable. It has a wide application range, that is, in food, chemicals, and encapsulation of pharmaceuticals. The technology can be divided into conventional spray drying and nano spray drying. The key advantage of nano spray drying is the production of drug-loaded nanosized particles for various drug delivery applications. The recent developments in nano spray dryer technology and the market launch of the Nano Spray Dryer B-90 by Bu ¨chi Labortechnik AG in 2009 enabled the production of submicron spray-dried particles. This review focuses on nanosized drug delivery systems intended for oral administration produced by nano spray drying. First, the nano spray drying concept, the basic technologies implemented in the equipment, and the effects of the various process parameters on the final dry submicron powder properties are presented. Then, the topics of new formulation strategies of oral drugs are highlighted with examples that have entered the research literature in recent years. Next, the subjects of direct conversion of poorly watersoluble drugs, encapsulation of drugs, and drying of preformed nanoparticles are considered. Finally, topics such as morphology, particle size, size distribution, surface analysis, bioavailability, drug release, release kinetics, and solid-state characterization (by differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, nuclear magnetic resonance) of oral drug delivery systems produced by nano spray drying are discussed. The review attempts to provide a comprehensive knowledge base with current literature and foresight to researchers working in the field of pharmaceutical technology and nanotechnology and especially in the field of nano spray drying.

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Administration Routes for Nano Drugs and Characterization of Nano Drug Loading

Cited by 18 publications

References 175 publications

Curcumin-loaded poly-ε-caprolactone nanoparticles show antioxidant and cytoprotective effects in the presence of reactive oxygen species

Curcumin-loaded poly-ε-caprolactone nanoparticles show antioxidant and cytoprotective effects in the presence of reactive oxygen species

Hydrogels as Controlled Drug Delivery System: A Brief Review of Properties Classification and Synthesis

Nano Spray-Dried Drugs for Oral Administration: A Review

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