2014
DOI: 10.1016/j.resuscitation.2014.08.036
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Admission interleukin-6 is associated with post resuscitation organ dysfunction and predicts long-term neurological outcome after out-of-hospital ventricular fibrillation

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Cited by 61 publications
(53 citation statements)
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“…However, level of inflammation has been associated with both endothelial disturbances, microcirculatory impairment and mortality (17,20,21). The magnitude of an early inflammatory response assessed by IL-6 associates with greater severity of organ dysfunction and adverse outcome, whereas procalcitonin and CRP are not elevated in the early time course after OHCA (12,22). The dynamic process of the inflammatory response is important to acknowledge when evaluating serial measurements of inflammatory markers as demonstrated by previous studies (23,24).…”
Section: Discussionmentioning
confidence: 96%
“…However, level of inflammation has been associated with both endothelial disturbances, microcirculatory impairment and mortality (17,20,21). The magnitude of an early inflammatory response assessed by IL-6 associates with greater severity of organ dysfunction and adverse outcome, whereas procalcitonin and CRP are not elevated in the early time course after OHCA (12,22). The dynamic process of the inflammatory response is important to acknowledge when evaluating serial measurements of inflammatory markers as demonstrated by previous studies (23,24).…”
Section: Discussionmentioning
confidence: 96%
“…following elective surgery or in patients with pneumonia . Furthermore, IL‐6 levels are associated with organ failure and impaired (functional) outcome following severe injury, cardiac surgery, cardiac arrest, stroke and sepsis . With respect to renal function, IL‐6 plays a critical role in the development of AKI, independently predicting mortality in patients starting dialysis and predicting AKI following cardiac surgery .…”
Section: Discussionmentioning
confidence: 99%
“…At the bedside, changes on the clinical exam, brain imaging, and increased levels of neuron-specific enolase all reflect the evolution of such pathological cascades (Calderon, et al 2014). The role of systemic inflammation in post-ischemic neurodegeneration is also well recognized (Samborska-Sablik, et al 2011, Vaahersalo, et al 2014). For example, serum levels of IL-6 and other cytokines correlate with poor neurologic recovery after cardiac arrest and in-hospital death following ischemic stroke (Rallidis, et al 2006, Vaahersalo, et al 2014).…”
Section: Discussionmentioning
confidence: 99%
“…The role of systemic inflammation in post-ischemic neurodegeneration is also well recognized (Samborska-Sablik, et al 2011, Vaahersalo, et al 2014). For example, serum levels of IL-6 and other cytokines correlate with poor neurologic recovery after cardiac arrest and in-hospital death following ischemic stroke (Rallidis, et al 2006, Vaahersalo, et al 2014). And in the case of prolonged cardiac arrest, the induced cytokine storm produces endothelial dysfunction, coagulation defects, and multi-organ failure mimicking septic shock (Adrie, et al 2002).…”
Section: Discussionmentioning
confidence: 99%