Admixture analysis of age at onset in first episode bipolar disorder

Nowrouzi, Behdin; McIntyre, Roger S.; MacQueen, Glenda; Kennedy, Sidney H.; Kennedy, James L.; Ravindran, Arun; Yatham, Lakshmi N.; Luca, Vincenzo De

doi:10.1016/j.jad.2016.04.006

Cited by 23 publications

(13 citation statements)

References 27 publications

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“…These summary statistics related to participant characteristics (sample size, age range and gender ratio); diagnostic criteria used; age‐at‐onset definition; recruitment settings (clinic, community and hospital) and study locations. Two studies 14 , 15 recruited mixed samples which included participants with schizoaffective disorder; where possible, we only included participants with a BD diagnosis in analyses and samples with schizoaffective disorder participants were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…Thirteen studies (62%, n = 13) used DSM-IV criteria alone to determine a bipolar disorder diagnosis. 5,[7][8][9]14,[22][23][24][25][26][27][28][29] Two studies used DSM-IV or ICD-10 criteria, 30,31 one used DSM-IV or Research Diagnostic Criteria (RDC), 32 one used DSM-IV or DSM-III-R criteria, 15 one used both DSM-III-R and RDC, 33 two used RDC only 34,35 and one used case records only. 36 F I G U R E 1 PRISMA flowchart of included studies [Colour figure can be viewed at wileyonlinelibrary.com]…”

Section: Diagnostic Criteriamentioning

confidence: 99%

“…There were three separate types of distributions found for bipolar disorder age at onset across the 21 articles. Fourteen studies showed a trimodal distribution, 5,7,8,15,[25][26][27][28][29][30][32][33][34][35] five a bimodal distribution 9,14,22,23,36 and two studies examined cohort effects on AAO. 24,31…”

Section: Age-at-onset Distributionsmentioning

confidence: 99%

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Bipolar disorder: Trimodal age‐at‐onset distribution

et al. 2020

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Bipolar disorder (BD) is a chronic mental health disorder with significant morbidity and mortality that affects between 1-4% of the population. 1 Age at onset in BD has been recognised as being important in the course and outcome of the disorder. Meta-analytic results suggest that an early (compared to late) age at onset in bipolar disorder is associated with a longer delay to treatment, greater severity of depression and higher levels of comorbid anxiety and substance abuse. 2,3 Given this differing clinical trajectory between early-versus late-onset BD, it has been proposed that age at onset (AAO) may be a key variable in delineating more

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Section: Methodsmentioning

confidence: 99%

Section: Diagnostic Criteriamentioning

confidence: 99%

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Bipolar disorder: Trimodal age‐at‐onset distribution

et al. 2020

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“…These hypotheses might also apply to bipolar disorder, as GWAS research suggests the bipolar disorder and schizophrenia share an underlying genetic risk (Prata, Costa‐Neves, Cosme, & Vassos, ). Bipolar disorder, which usually onsets in late adolescence or early adulthood (Leboyer, Henry, Paillere‐Martinot, & Bellivier, ; Nowrouzi et al, ), is characterized by rapid shifts between symptoms of mania and depression (Merikangas et al, ). Manic symptoms—elevated mood, high energy, reduced need for sleep, and increased risk‐taking—are probably functional when “profitable” opportunities present themselves, but in bipolar disorder seem to onset regardless of such opportunities.…”

Section: Developmental Disordersmentioning

confidence: 99%

Mental health is biological health: Why tackling “diseases of the mind” is an imperative for biological anthropology in the 21st century

Syme

Hagen

2019

American J Phys Anthropol

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The germ theory of disease and the attendant public health initiatives, including sanitation, vaccination, and antibiotic treatment, led to dramatic increases in global life expectancy. As the prevalence of infectious disease declines, mental disorders are emerging as major contributors to the global burden of disease. Scientists understand little about the etiology of mental disorders, however, and many of the most popular psychopharmacological treatments, such as antidepressants and antipsychotics, have only moderate-to-weak efficacy in treating symptoms and fail to target biological systems that correspond to discrete psychiatric syndromes. Consequently, despite dramatic increases in the treatment of some mental disorders, there has been no decrease in the prevalence of most mental disorders since accurate record keeping began. Many researchers and theorists are therefore endeavoring to rethink psychiatry from the ground-up. Anthropology, especially biological anthropology, can offer critical theoretical and empirical insights to combat mental illness globally. Biological anthropologists are unique in that we take a panhuman approach to human health and behavior and are trained to address each of Tinbergen's four levels of analysis as well as culture. The field is thus exceptionally well-situated to help resolve the mysteries of mental illness by integrating biological, evolutionary, and sociocultural perspectives. K E Y W O R D S evolutionary medicine, mental health, psychopathology

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“…In fact, 40% (1) to 60% (2) of patients discontinue lithium after 5-7 years, and despite good adherence, some 13% of patients who were responders for five years, become resistant to lithium treatment after 10 years (3). BD has its onset usually in late adolescence and early adulthood, less often in later adulthood or advanced age, and seldom during childhood (4), with each range of age at onset displaying a normal-like distribution (5). Since it runs a cyclic course, with manic and depressive episodes and with relatively asymptomatic intervals, and is a biologically heterogeneous entity with precise neural (6)(7)(8)(9) and peripheral correlates (10), BD needs to be treated according to subtype and for the entire life span (11).…”

Section: Introductionmentioning

confidence: 99%

Stabilization Beyond Mood: Stabilizing Patients With Bipolar Disorder in the Various Phases of Life

et al. 2020

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Background: There are different ways to define stabilization and currently, the main standpoint regards it as no-depression/no-mania. Furthermore, each person is physiologically different from childhood to adulthood, and in old age, thus the meaning of stabilization should take into account both growth and maturity. We aimed to review systematically studies focusing on mood stabilization in all phases of bipolar disorder (BD) and across all life phases, including pregnancy and the perinatal period, which is still a different phase in women's life cycles. Methods: We carried out a PubMed search focusing on studies of bipolar disorder treated with drugs and aimed at stabilization with the following search strategy stabiliz*[ti] OR stabilis*[ti] OR stable[ti] OR stability[ti]) AND mood[ti] AND bipolar. In conducting our review, we followed the PRISMA statement. Agreement on inclusion was reached by consensus of all authors through a Delphi rounds procedure.

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Admixture analysis of age at onset in first episode bipolar disorder

Cited by 23 publications

References 27 publications

Bipolar disorder: Trimodal age‐at‐onset distribution

Bipolar disorder: Trimodal age‐at‐onset distribution

Mental health is biological health: Why tackling “diseases of the mind” is an imperative for biological anthropology in the 21st century

Stabilization Beyond Mood: Stabilizing Patients With Bipolar Disorder in the Various Phases of Life

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