Bipolar disorder: Trimodal age‐at‐onset distribution

Bolton, Sorcha; Warner, Jeremy; Harriss, Eli; Geddes, John; Saunders, Kate

doi:10.1111/bdi.13016

Cited by 55 publications

(30 citation statements)

References 89 publications

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“…However, other studies refer EOBD with an outstart before age 18, thus considering the onset of the disease to be in the period of childhood and adolescence (Connor et al, 2017; Joslyn et al, 2016; Liu et al, 2020; Schürhoff et al, 2000) and LOBD as BD occurring in the middle phase of adult life, that is, at ages over 40 years old (Beyer et al, 2003; Schürhoff et al, 2000). In addition, a recent systematic review indicated that a three‐component model (early, middle and late onset) best describes the age at onset distribution of BD (Bolton et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Social support in patients with bipolar disorder and differing ages at onset

Studart‐Bottó

Bezerra-Filho

Sarmento

et al. 2021

Clin Psychology and Psychoth

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Objective:The main purpose of this study was to evaluate the association between age at onset and social support in outpatients with bipolar disorder who were in the recovery phase. We also investigated the association between age at onset and disability.Methods: A total of 180 bipolar disorder I outpatients, of whom 50 had early onset with age at onset ≤18 years old, 108 had middle onset with age at onset between 19 and 39 years old, and 22 had late onset with age at onset ≥40 years old, were assessed with the Medical Outcomes Study Social Support Scale and Sheehan Disability Scale. Results:The early onset group had lower tangible social support, longer length of illness, more childless participants, lower income and more suicide attempters than the late onset group. Conclusions:Early onset seems to have inferior outcomes in tangible social support than late onset, but this trend should be considered as a starting point for future studies.

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Section: Introductionmentioning

confidence: 99%

Social support in patients with bipolar disorder and differing ages at onset

Studart‐Bottó

Bezerra-Filho

Sarmento

et al. 2021

Clin Psychology and Psychoth

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“…Age of onset is an understudied variable. BD has been shown to have either a trimodal (early onset, mid-onset and late-onset) or a bimodal age of onset in a recent review [ 67 ]. The average age of early onset was 17.3 years (SD = 1.19) corresponding to 45% of total cases, for mid-onset 26.0 years (SD = 1.72) with 35% of total cases and for late onset 41.9 years (SD = 6.16) in 20% of total cases.…”

Section: Discussionmentioning

confidence: 99%

Blue Light Blocking Treatment for the Treatment of Bipolar Disorder: Directions for Research and Practice

Mylona

Floros

2022

JCM

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Recent results from a small number of clinical studies have resulted in the suggestion that the process of blocking the transmission of shorter-wavelength light (‘blue light’ with a wave length of 450 nm to 470 nm) may have a beneficial role in the treatment of bipolar disorder. This critical review will appraise the quality of evidence so far as to these claims, assess the neurobiology that could be implicated in the underlying processes while introducing a common set of research criteria for the field.

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“…Earlier age of first mood symptoms was also related to lower right superior frontal surface area. It was suggested that early and late onset of BD have distinct neuropathological features ( Bolton et al, 2021 ) and are related to differences in frontal cortical thickness ( Oertel-Knochel et al, 2015 ). We speculate that there may be relationships between CM exposure and the pathophysiology underlying different ages of onset, but large studies with balanced age of onset groups are warranted.…”

Section: Discussionmentioning

confidence: 99%