Adnexal Carcinomas Treated With Mohs Micrographic Surgery: A Comprehensive Review

Tolkachjov, Stanislav N.

doi:10.1097/dss.0000000000001167

Cited by 33 publications

(21 citation statements)

References 91 publications

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“…A 2017 review of PMC treated with MMS found a 9.6% (6/31) recurrence rate, a sizeable improvement over excision alone. 8 For facial PMCs, MMS has advantages over standard excisions because of improved tissue conservation and better margin control. A variation of Mohs surgery described to treat PMC is slow Mohs (staged excision with complete peripheral and deep margin assessment using permanent sections) aided by mucin staining (eg, Alician blue) or cytokeratin immunohistochemistry.…”

Section: Discussionmentioning

confidence: 99%

Multifocal primary mucinous carcinoma of the eyelids: Implications for management

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Multifocal primary mucinous carcinoma of the eyelids: Implications for management

et al. 2021

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“…Table 1 demonstrates MMS efficacy for different cutaneous malignancies. 1 , 3 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 …”

Section: Wide Local Excision Compared To Mmsmentioning

confidence: 99%

Mohs micrographic surgery: a review of indications, technique, outcomes, and considerations

Bittner

Cerci

Kubo³

et al. 2021

Anais Brasileiros de Dermatologia

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Mohs micrographic surgery is a specialized form of skin cancer surgery that has the highest cure rates for several cutaneous malignancies. Certain skin cancers can have small extensions or “roots” that may be missed if an excised tumor is serially cross-sectioned in a “bread-loaf” fashion, commonly performed on excision specimens. The method of Mohs micrographic surgery is unique in that the dermatologist (Mohs surgeon) acts as both surgeon and pathologist, from the preoperative considerations until the reconstruction. Since Dr. Mohs’s initial work in the 1930s, the practice of Mohs micrographic surgery has become increasingly widespread among the dermatologic surgery community worldwide and is considered the treatment of choice for many common and uncommon cutaneous neoplasms. Mohs micrographic surgery spares the maximal amount of normal tissue and is a safe procedure with very few complications, most of them managed by Mohs surgeons in their offices. Mohs micrographic surgery is the standard of care for high risks basal cell carcinomas and cutaneous squamous cell carcinoma and is commonly and increasingly used for melanoma and other rare tumors with superior cure rates. This review better familiarizes the dermatologists with the technique, explains the difference between Mohs micrographic surgery and wide local excision, and discusses its main indications.

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“…7 Yet, these findings have only been supported by a limited number of observational studies. [8][9][10] After resection, the utility of adjuvant radiation remains unclear and has limited supporting literature. One retrospective study of 13 patients showed lower recurrence rates in those who received adjuvant radiation compared to those who did not.…”

Section: Introductionmentioning

confidence: 99%

“…Resection by Mohs Micrographic Surgery (MMS) is also recommended, and some studies have correlated MMS with lower recurrence and metastatic rates 7 . Yet, these findings have only been supported by a limited number of observational studies 8‐10 . After resection, the utility of adjuvant radiation remains unclear and has limited supporting literature.…”

Section: Introductionmentioning

confidence: 99%

Localized sebaceous carcinoma treatment: Wide local excision verses Mohs micrographic surgery

Elias¹,

Skula²,

Behbahani³

et al. 2020

Dermatologic Therapy

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The optimal surgical management of sebaceous carcinoma (SC) has yet to be determined between Mohs micrographic surgery (MMS) and wide local excision (WLE). To investigate overall survival (OS) differences for SC undergoing WLE or MMS, The National Cancer Database (NCDB) was queried for all SC from 2004 to 2015 (n = 2863). Cases missing staging data, undergoing palliative care, showing lymph node extension, or of AJCC Stage III/IV were omitted. Chi-squared tests were used to analyze patient demographics, cancer characteristics, and treatment modalities. Kaplan-Meier and Cox proportional hazards regression modeling analyzed OS outcomes. A total of 554 cases met inclusion criteria (WLE [n = 243], MMS [n = 311]). Multivariate analysis revealed that cases treated in academic facilities (ref: non-acad; OR = 2.273; CI95% [1.448-3.568]; P < .001] were independently associated with greater MMS rates, whereas those with primaries on the trunk (ref: head/neck OR = 0.359; CI95%[0.203-0.634]; P < .001) and extremities (ref: head/neck OR = 0.399; CI95% [0.182-0.877]; P = .022) held lower MMS rates. Between surgical modalities, Kaplan-Meier survival showed no significant difference in outcomes (P = .611), with WLE and MMS demonstrating 5-year OS rates of 65.8% and 61.4%, respectively. On Cox proportional hazard regression, the survival outcomes of MMS and WLE did not show any significant differences in OS (HR = 0.832; CI95% [0.996-3.662]; P = .334). MMS and WLE of localized SC demonstrate similar overall survival outcomes. MMS may be preferred for margin control, tissue conservation, and cosmesis.

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Adnexal Carcinomas Treated With Mohs Micrographic Surgery: A Comprehensive Review

Abstract: The rarity of ACs and the lack of comparative data on treatment makes conclusive recommendations on treatment difficult. Recent large case series and reviews suggest MMS is a useful and possibly superior treatment for AC and should be considered if primary cutaneous disease is suspected.

Cited by 33 publications

References 91 publications

Multifocal primary mucinous carcinoma of the eyelids: Implications for management

Multifocal primary mucinous carcinoma of the eyelids: Implications for management

Mohs micrographic surgery: a review of indications, technique, outcomes, and considerations

Localized sebaceous carcinoma treatment: Wide local excision verses Mohs micrographic surgery

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