Adolescent dietary vitamin D and sun exposure in relation to benign breast disease

Abstract

Purpose Vitamin D may reduce cell proliferation and tumor growth in breast tissue, and exposure may be most important during adolescence when breast tissue is developing. In the Nurses’ Health Study II, higher recalled adolescent vitamin D intake was associated with a lower risk of benign breast disease (BBD). Our study aim was to assess adolescent vitamin D exposure in relation to BBD in young women. Methods Vitamin D was assessed in 6,593 adolescent girls (9 to 15 years of age at baseline) in the prospective Growing Up Today Study cohort using the mean energy-adjusted intakes from food frequency questionnaires in 1996, 1997, and 1998. In 1999, 5286 girls reported skin color, sunscreen use, tanning bed use, and number of sunburns in the past year, and we used state of residence to assess low vs. high ultraviolet (UV) index. Biopsy-confirmed BBD was reported on questionnaires in 2005, 2007, and 2010 (n=122). Results Dietary vitamin D, tanning behaviors, and other sun exposure variables were not significantly associated with BBD in logistic regression models adjusted for age, family history of breast cancer or BBD, age at menarche, nulliparity, alcohol intake, body mass index, and physical activity. The relative risk for the top (>467 IU/day) vs. bottom (<243 IU/day) quartile of vitamin D intake was 0.76 (95% CI: 0.47, 1.23). Conclusions Sun exposure was not significantly associated with BBD in this prospective cohort study. However, a suggestive inverse association between dietary vitamin D and BBD was observed that merits further study.

The Correlation of Plasma 25-Hydroxyvitamin D Deficiency With Risk of Breast Neoplasms: A Systematic Review

“…Biological and epidemiological data have revealed the protective functions of vitamin D against different cancers especially breast cancer ( 13 - 15 ) and the potential role of VDR gene polymorphisms and risk of cancer ( 16 - 18 ). Interestingly, it was found that people with higher vitamin D levels have shown reduced incidence of breast cancer ( 19 , 20 ).…”

Vitamin D Level in Breast Cancer Premenopausal Patients before and after Adjuvant Therapy

“…Vitamin D binds to and activates the nuclear VDR which regulates as much as 3% to 5% of the human genome (Oh et al, 2007). Interestingly, it was found that people with higher vitamin D levels have shown reduced incidence of breast cancer (Garland et al, 2009 andBoeke et al, 2015).Among Egyptian women,vitamin D deficiency was identified in middle-aged, postmenopausal and geriatric women (Botros et al, 2015). According to De Lyra et al (2006) suboptimal vitamin D levels might lead to cancer development through impairment of cell proliferation, differentiation, apoptosis, and angiogenesis.…”

Kan 25-hidroksi D vitamini düzeyinin fibrokistik meme hastalığı ve meme yoğunluğu ile ilişkisi

“…The importance of vitamin D, long-known for its crucial role in calcium homeostasis, and bone metabolism, is better understood recently by subsequent publication of several studies demonstrating the association of vitamin D levels with many organ cancers, heart disease, diabetes mellitus, and fertility rates 14,15 . It has long been speculated that vitamin D deficiency would accelerate the cellular proliferation of breast tissue in women and lead to the formation of breast masses 16 . Garland et al demonstrated a relation between serum vitamin D levels and breast cancer in 2007 which accelerated the studies on this subject subsequently.…”