Adolescent exposure to fluoxetine impairs serial pattern learning in the serial multiple choice (SMC) task in adult rats

Chronic fluoxetine treatment impairs motivation and reward learning by affecting neuronal plasticity in the central amygdala

“…This would be in agreement with recent findings illustrating that fluoxetine hinders neurogenesis after 6 and 9, but not after 3 weeks of intake (Ohira, Hagihara, Miwa, Nakamura, & Miyakawa, 2019). Still, the length of the applied treatment may not be an exclusive explanation of the discrepancies in the literature, as deteriorating effects of fluoxetine have been reported after chronic drug administration significantly shorter than the one used in the present research (Dringenberg, Branfield Day, & Choi, 2014;Eisenreich, Greene, & Szalda-Petree, 2017;Flores-Ramirez et al, 2019;Frick, Bernardez-Vidal, Hocht, Zanutto, & Rapanelli, 2015;Sharp et al, 2019;Takahashi et al, 2005). In addition, as our experiments were performed in an inbred strain from a local colony, it may be that the reported effects occur only against this specific genetic background.…”

“…Regrettably, studies describing the influence of fluoxetine on cognitive and emotional well‐being in such individuals are still rare(Olguner Eker, Özsoy, Eker, & Doğan, 2017; Serretti et al, 2010). However, there is increasing evidence in both healthy animals and human subjects that the drug hinders reward processing (Eisenreich, Greene, & Szalda‐Petree, 2017; Flores‐Ramirez et al, 2019; Sharp et al, 2019) and can suppress neuronal plasticity (Dringenberg, Branfield Day, & Choi, 2014). In particular, it has been reported that chronic fluoxetine treatment decreases amygdala activation in healthy adults (Takahashi et al, 2005).…”

Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents – systematic review and meta-analysis

“…From 63 full-text articles assessed for eligibility 43 studies were excluded. Among studies reporting behavioral outcomes, in twelve trials behavioral measures were reported for early adulthood (after PD 60-mice, or after PD 70rats) [70][71][72][73][74][75][76][77][78][79][80][81], while in four trials, behavioral measures were reported for later (after PD 100) adulthood [82][83][84][85]. Eight studies did not report behavioral outcomes of interest or provided data as a statistical analysis only [86][87][88][89][90][91][92][93].…”

Simplicity From Complexity in Vertebrate Behavior: Macphail (1987) Revisited

“…Furthermore, the learning and memory systems involved depend on different behavioral and neural systems as shown by dissociations observed in adulthood long after chronic adolescent drug exposure (Pickens et al, 2013;Renaud et al, 2015;Rowan et al, 2015;Renaud and Fountain, 2016;Sharp et al, 2019). Similar dissociations of cognitive behavioral systems can be seen in normal rats administered acute muscarinic cholinergic blockade (Pickens et al, 2013;Renaud et al, 2015;Rowan et al, 2015;Renaud and Fountain, 2016;Sharp et al, 2019).…”

“…Furthermore, the learning and memory systems involved depend on different behavioral and neural systems as shown by dissociations observed in adulthood long after chronic adolescent drug exposure (Pickens et al, 2013;Renaud et al, 2015;Rowan et al, 2015;Renaud and Fountain, 2016;Sharp et al, 2019). Similar dissociations of cognitive behavioral systems can be seen in normal rats administered acute muscarinic cholinergic blockade (Pickens et al, 2013;Renaud et al, 2015;Rowan et al, 2015;Renaud and Fountain, 2016;Sharp et al, 2019). The SMC method in mice and rats produces data comparable to data in humans in an analogous task (Fountain and Rowan, 1995) and rats use multiple cognitive processes concurrently: rule-learning, stimulus-response (S-R) learning, discrimination learning, and multiple-item memory Fountain, 2010, 2016).…”