Adolescent oxytocin response to stress and its behavioral and endocrine correlates

Bernhard, Anka; Merwe, Cindy van der; Ackermann, Kathrin; Martinelli, Anne; Neumann, Inga D.; Freitag, Christine M.

doi:10.1016/j.yhbeh.2018.08.010

Cited by 38 publications

(59 citation statements)

References 59 publications

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“…Higher baseline oxytocin has previously been related to increased anxiety and relationship distress (Taylor et al, 2006;Turner, Altemus, Enos, Cooper, & McGuinness, 1999). No effect of oxytocin on the cortisol reaction was found, which parallels earlier findings by Taylor et al (2006) but contrasts research on adolescents (Bernhard et al, 2018). Our descriptive data indicate that the TSST provocation resulted in reduced oxytocin concentrations in allergic participants, while in their nonallergic counterparts oxytocin increased, marked by a trend toward significance in delta oxytocin.…”

Section: Discussionsupporting

confidence: 78%

Salivary cortisol responses to acute stress vary between allergic and healthy individuals: the role of plasma oxytocin, emotion regulation strategies, reported stress and anxiety

Glenk

Kothgassner

Felnhofer

et al. 2019

Stress

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Numerous studies have demonstrated that acute psychological stress, induced by the Trier Social Stress Test (TSST) paradigm, affects salivary cortisol secretion and self-reported stress measures including anxiety. Allergy has been related to altered cortisol responsiveness and increased stress vulnerability. Here, we investigated acute stress responses and emotion regulation strategies in cohorts of allergic and healthy individuals. Groups of allergics and healthy individuals were subjected to the TSST and experienced levels of stress and anxiety, as well as emotion regulation strategies, were assessed. Cortisol and oxytocin concentrations were measured in saliva or plasma. The present findings confirm earlier results of altered stress responsiveness in allergic individuals. Acute stress by the TSST evoked higher physiological arousal in allergics by means of salivary cortisol secretion. Allergics also scored higher on emotion suppression. However, individuals who were more likely to use reappraisal recovered more efficiently from the cortisol increase. No such effect for reappraisal was found in the healthy population. No differences in self-reported anxiety and stress emerged between the groups. Plasma oxytocin levels prior to the TSST were significantly higher in allergics. Our data corroborate earlier findings on altered stress susceptibility in allergics. Moreover, we identified differences in emotion regulation and oxytocin secretion which should be further explored. Accounting for the emerging global prevalence of allergy, more in-depth research into the experience of stress, coping strategies and stress-related molecules in allergic people is warranted.

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Section: Discussionsupporting

confidence: 78%

Salivary cortisol responses to acute stress vary between allergic and healthy individuals: the role of plasma oxytocin, emotion regulation strategies, reported stress and anxiety

Glenk

Kothgassner

Felnhofer

et al. 2019

Stress

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“…Salivary measurements, possibly with fewer sources of variation, offer an alternative for the assessment of changes in oxytocin (Carter et al, 2007;White-Traut et al, 2009;Bernhard et al, 2018;MacLean et al, 2018). Several studies have revealed reliable variations in oxytocin concentration, especially in rapid response to specific experiences, such as anticipation of breast feeding (White-Traut et al, 2009), sexual stimulation, exercise, affiliative social contact, and psychologic stress (Jong et al, 2015;MacLean et al, 2017a).…”

Section: Salivary Oxytocinmentioning

confidence: 99%

Is Oxytocin “Nature’s Medicine”?

et al. 2020

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“…Parallel oxytocin release within the hypothalamus and into the peripheral circulation has been shown during forced swimming stress 20 and shaker stress in rats. 26 In humans, stressful stimuli such as physical running, [27][28][29][30] exposure to psychological stress induced by the Trier social stress test, which consists of public speaking and mental arithmetic in front of unknown jury members, 28,31 and interpersonal distress 32 increase oxytocin in plasma or saliva, although no significant increase after psychological stress in urine of children 33 or in plasma of female participants 34 has also been reported. 26 In humans, stressful stimuli such as physical running, [27][28][29][30] exposure to psychological stress induced by the Trier social stress test, which consists of public speaking and mental arithmetic in front of unknown jury members, 28,31 and interpersonal distress 32 increase oxytocin in plasma or saliva, although no significant increase after psychological stress in urine of children 33 or in plasma of female participants 34 has also been reported.…”

Section: Activation Of Oxytocin Neurones After Stressful Stimulimentioning

confidence: 99%

“…18 However, dissociations between peripheral and central release have also been reported in rats during social defeat stress, 15 after adrenalectomy 20 and after administration of α-melanocyte-stimulating hormone (α-MSH). 26 In humans, stressful stimuli such as physical running, [27][28][29][30] exposure to psychological stress induced by the Trier social stress test, which consists of public speaking and mental arithmetic in front of unknown jury members, 28,31 and interpersonal distress 32 increase oxytocin in plasma or saliva, although no significant increase after psychological stress in urine of children 33 or in plasma of female participants 34 has also been reported.…”

Section: Activation Of Oxytocin Neurones After Stressful Stimulimentioning

confidence: 99%

Role of oxytocin in the control of stress and food intake

Onaka

Takayanagi

2019

J Neuroendocrinology

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Oxytocin neurones in the hypothalamus are activated by stressful stimuli and food intake. The oxytocin receptor is located in various brain regions, including the sensory information‐processing cerebral cortex; the cognitive information‐processing prefrontal cortex; reward‐related regions such as the ventral tegmental areas, nucleus accumbens and raphe nucleus; stress‐related areas such as the amygdala, hippocampus, ventrolateral part of the ventromedial hypothalamus and ventrolateral periaqueductal gray; homeostasis‐controlling hypothalamus; and the dorsal motor complex controlling intestinal functions. Oxytocin affects behavioural and neuroendocrine stress responses and terminates food intake by acting on the metabolic or nutritional homeostasis system, modulating emotional processing, reducing reward values of food intake, and facilitating sensory and cognitive processing via multiple brain regions. Oxytocin also plays a role in interactive actions between stress and food intake and contributes to adaptive active coping behaviours.

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Adolescent oxytocin response to stress and its behavioral and endocrine correlates

Cited by 38 publications

References 59 publications

Salivary cortisol responses to acute stress vary between allergic and healthy individuals: the role of plasma oxytocin, emotion regulation strategies, reported stress and anxiety

Salivary cortisol responses to acute stress vary between allergic and healthy individuals: the role of plasma oxytocin, emotion regulation strategies, reported stress and anxiety

Is Oxytocin “Nature’s Medicine”?

Role of oxytocin in the control of stress and food intake

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