Adolescent reproductive events and subsequent breast cancer risk.

Marcus, Pamela M.; Baird, Donna D.; Millikan, Robert C.; Moorman, Patricia G.; Qaqish, Bahjat F.; Newman, Beth

doi:10.2105/ajph.89.8.1244

Cited by 35 publications

(18 citation statements)

References 20 publications

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“…Our overall null association for breast cancer as it relates to induced abortion is in agreement with several recent casecontrol studies conducted among women of all age groups, 9 -11 and restricted to younger women. [12][13][14] We are also in agreement with 2 recent cohort studies that reported relative risks of 1.0 (95% CI 0.94 -1.06) 15 and 1.1 (95% CI 0.8 -1.6), 2 respectively. Nor did we find an increased risk associated with several induced abortions.…”

Section: Resultssupporting

confidence: 92%

Abortion history and breast cancer risk: Results from the Shanghai breast cancer study

et al. 2001

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Studies of the association between induced abortion and breast cancer risk have been inconsistent, perhaps due to underreporting of abortions. Induced abortion is a well-accepted family planning procedure in China, and women who have several induced abortions do not feel stigmatized. The authors used data from a population-based case-control study of breast cancer among women age 25-64 conducted between 1996 and 1998 in urban Shanghai to assess whether a history of and the number of induced abortions were related to breast cancer risk. In-person interviews were completed with 1,459 incident breast cancer cases ascertained through a population-based cancer registry, and 1,556 controls randomly selected from the general population in Shanghai (with respective response rates of 91% and 90% Studies of induced abortion and breast cancer risk have been inconsistent. Underreporting of induced abortion is suspected, 1 which may be reflected in the low reported percentages of women who had undergone the procedure in these studies. In the majority of previous studies of this association fewer than 20% of women have reported induced abortions. The Iowa Women's Health Study, a cohort study, had the lowest percentage of reported induced abortions (2%), and found no association between induced abortion and breast cancer risk (OR ϭ 1.1, 95% CI 0.8 -1.6). 2 An intermediate percentage of reported induced abortions (39%) was found in a Greek case-control study that reported an elevated risk of breast cancer associated with induced abortion (OR ϭ 1.51, 95% CI 1.28 -1.84). 3 The highest percentage of reported induced abortions (76%) was seen in a Russian case-control study that reported no association for 1 abortion (OR ϭ 1.0, 95% CI 0.7-1.4) and a borderline reduced risk for 2 or more abortions (OR ϭ 0.7, 95% CI 0.6 -1.0). 4 Remennick 5 postulated that should induced abortion be related to breast cancer Russian women may be at a greater risk given the extremely frequent use of the procedure. The same may be true of women in China that had 1 of the highest induced abortion rates in the world during the childbearing years for the majority of women in this study. 6 This study was conducted to assess whether a history of and the number of induced abortions were related to breast cancer risk. The lack of social stigma associated with induced abortion in China may limit the amount of underreporting of the procedure and present a clearer picture of this association. MATERIAL AND METHODSDetailed methods of this population-based case-control study appear elsewhere. 7 Briefly, all women age 25-64 years who were permanent residents of urban Shanghai at the time of diagnosis of first primary invasive breast cancer (August 1996 through March 1998) were eligible for the study. Two senior pathologists histologically confirmed all diagnoses. We used rapid case ascertainment supplemented by the Shanghai Cancer Registry to identify breast cancer cases who had no prior history of cancer and were alive at the time of interview. A total of 1,459 breas...

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Section: Resultssupporting

confidence: 92%

Abortion history and breast cancer risk: Results from the Shanghai breast cancer study

et al. 2001

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“…However, the absence of the common 19-repeat allele in the IGF1 gene is associated with high IGF-1 levels during OC use in nulliparous women (Jernström et al, 2001a, b). The risk of early-onset breast cancer after teenage OC use varies considerably between ethnic groups (Marcus et al, 1999), and appears to correlate with the relative frequencies of the absence of the 19-repeat allele among these ethnic groups (Jernström et al, 2001a). In addition, the absence of the 19-repeat allele appears to mitigate the normal agerelated decline in IGF-1 levels (Rietveld et al, 2003).…”

mentioning

confidence: 99%

Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families

et al. 2005

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BRCA1/2 mutations predispose to early-onset breast cancer, especially after oral contraceptive (OC) use and pregnancy. However, the majority of breast cancers might be due to more prevalent low-penetrance genes, which may also modify the risk in BRCA mutation carriers. The absence of the IGF1 19-repeat allele has been associated with high insulin-like growth factor-1 (IGF-1) levels during OC use. High IGF-1 levels are linked to early-onset breast cancer and larger breast volumes in the general population. The goal of this study was to elucidate the relationships between IGF1 genotype, early-onset breast cancer, breast volume, circulating IGF-1 levels and OC use in a prospective cohort of 258 healthy women p40 years old from high-risk breast cancer families. All women completed a questionnaire including information on reproductive factors and OC use. We measured the height, weight, breast volumes and plasma IGF-1 levels. IGF-1 levels were similar among parous and nulliparous women not using OCs. In all, 13% had no IGF1 19-repeat allele. There was an interaction between IGF1 genotype and OC use on IGF-1 levels (P ¼ 0.026) in nulliparous women and another interaction between IGF1 genotype and parity on breast volume (P ¼ 0.01). Absence of the 19-repeat allele was associated with high IGF-1 levels in nulliparous OC users and with larger breast volumes in parous women and OC users. Incident breast cancers were also more common in women without the 19-repeat allele (log rank P ¼ 0.002). Our results suggest that lack of the IGF1 19-repeat allele modifies IGF-1 levels, breast volume and possibly early-onset breast cancer risk after hormone exposure in young high-risk women.

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“…Outro fator pouco estudado e que tem grande impacto no futuro da adolescente é a relação entre amamentação e o risco de câncer de mama. Ao engravidar, as mamas passam por um processo de maturação, o que se considera fator de proteção contra o câncer de mama 34,35 . Há evidências também da proteção da amamentação contra alguns tipos de câncer epitelial do ovário 35 .…”

Section: Implicações Para O Desenvolvimento Da Adolescenteunclassified

Considerações atuais sobre gravidez na adolescência

Manfré¹,

Queiróz²,

Matthes³

2010

Rev Bras Med Fam e Com

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ResumoA gravidez na adolescência vem adquirindo proporções significativas. Estima-se que de 20 a 25% do total de gestantes no Brasil sejam adolescentes, ou seja, em média, há uma adolescente entre cada cinco mulheres grávidas. O presente trabalho buscou, por meio de uma análise da literatura atual, levantar os principais aspectos que envolvem a gravidez na adolescência, bem como suas consequências na vida da adolescente, de seu filho e no meio social em que vive. Foi possível concluir que a atuação dos profissionais de saúde, pais e educadores mostra-se fundamental na construção do conhecimento sobre sexualidade dos adolescentes. A aplicação desse conhecimento é uma forma de prevenir a gravidez na adolescência, evitando que o futuro da adolescente e do seu filho seja comprometido. AbstractTeenage pregnancy has acquired significant proportions. It is estimated that 20 to 25% of all pregnant women in Brazil are teenagers. The present study, through an analysis of the current literature, examines the main aspects involving pregnancy during adolescence, along with its consequences on the life of young mothers, their children and social environment. We conclude that the efforts of health care professionals, parents and educators are crucial to increase awareness of adolescent sexuality. The application of this knowledge is a way to prevent teen pregnancy, thus avoiding the harmful effects on young mothers and their children.

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Adolescent reproductive events and subsequent breast cancer risk.

Abstract: BriefsConnecticut and its influence on the reporting of melanoma. JAm Acad Dermatol. 1992;26: 198-202. 11. Karagas MR, Thomas DB, Roth GJ, Johnson LK, Weiss NS. The effects of changes in health care delivery on the reported incidence of cutaneous melanoma in western Washington State.

Cited by 35 publications

References 20 publications

Abortion history and breast cancer risk: Results from the Shanghai breast cancer study

Abortion history and breast cancer risk: Results from the Shanghai breast cancer study

Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families

Considerações atuais sobre gravidez na adolescência

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