Adolescents and Young Adults with Cancer: Survivorship and Special Considerations

Joffe, Lenat; Steinberg, Dara M.; Strohli, Tiffany; Beauchemin, Melissa

doi:10.3928/19382359-20211209-03

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…AYAs are recognized to be a unique and complex population, reporting higher rates of distress and lower QOL than older adults with cancer ( 125 ). For example, a recent study reported that AYA cancer survivors report more anxiety (15.1% vs. 6.6%) and mood disorders (14.8% vs. 8.9%) than older adults ( 126 ).…”

Section: Discussionmentioning

confidence: 99%

LGBTQI cancer patients’ quality of life and distress: A comparison by gender, sexuality, age, cancer type and geographical remoteness

Ussher

Allison²,

Perz³

et al. 2022

Front. Oncol.

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BackgroundThere is growing acknowledgement of the psycho-social vulnerability of lesbian, gay, bisexual, transgender, queer and/or intersex (LGBTQI) people with cancer. The majority of research to date has focused on cisgender adults with breast or prostate cancer.Study AimThis study examined psycho-social factors associated with distress and quality of life for LGBTQI cancer patients and survivors, across a range of sexualities and gender identities, intersex status, tumor types, ages and urban/rural/remote location using an intersectional theoretical framework.Method430 LGBTQI people with cancer completed an online survey, measuring distress, quality of life (QOL), and a range of psycho-social variables. Participants included 216 (50.2%) cisgender women, 145 (33.7%) cisgender men, and 63 (14.7%) transgender and gender diverse (TGD) people. Thirty-one (7.2%) participants reported intersex variation and 90 (20%) were adolescents or young adults (AYA), aged 15-39. The majority lived in urban areas (54.4%) and identified as lesbian, gay or bisexual (73.7%), with 10.9% identifying as bisexual, and 10.5% as queer, including reproductive (32.4%) and non-reproductive (67.6%) cancers.ResultsForty-one percent of participants reported high or very high distress levels, 3-6 times higher than previous non-LGBTQI cancer studies. Higher rates of distress and lower QOL were identified in TGD compared to cisgender people, AYAs compared to older people, those who identify as bisexual or queer, compared to those who identify as lesbian, gay or homosexual, and those who live in rural or regional areas, compared to urban areas. Elevated distress and lower QOL was associated with greater minority stress (discrimination in life and in cancer care, discomfort being LGBTQI, lower outness) and lower social support, in these subgroups. There were no differences between reproductive and non-reproductive cancers. For the whole sample, distress and poor QOL were associated with physical and sexual concerns, the impact of cancer on gender and LGBTQI identities, minority stress, and lack of social support.ConclusionLGBTQI people with cancer are at high risk of distress and impaired QOL. Research and oncology healthcare practice needs to recognize the diversity of LGBTQI communities, and the ways in which minority stress and lack of social support may affect wellbeing.

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Section: Discussionmentioning

confidence: 99%

LGBTQI cancer patients’ quality of life and distress: A comparison by gender, sexuality, age, cancer type and geographical remoteness

Ussher

Allison²,

Perz³

et al. 2022

Front. Oncol.

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“…Nonetheless, radiotherapy remains integral in the cure of many childhood cancers, and although childhood cancer is rare, adult CCS are a growing, medically complex population [ 6 ]. Survivorship programs dedicated to caring for CCS provide individualized, guideline-based care plans to ensure that CCS receive critical surveillance as they age from childhood into adolescence and adulthood [ 9 •].…”

Section: Special Considerations For Ccsmentioning

confidence: 99%

The Evaluation and Management of Visceral Complications in Radiation Fibrosis Syndrome Part 1

Jacob

Bade

Joffe

et al. 2023

Curr Phys Med Rehabil Rep

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External beam ionizing radiation is a fundamental component of cancer treatment and is incorporated into approximately 50% of cancer treatments. Radiation therapy causes cell death directly by apoptosis and indirectly by disruption of mitosis. Purpose of Review This study aims to inform rehabilitation clinicians of the visceral toxicities of radiation fibrosis syndrome and how to detect and diagnose these complications. Recent Findings Latest research indicates that radiation toxicity is primarily related to radiation dose, patient co-morbidity, and concomitant use of chemotherapies and immunotherapies for the treatment of cancer. While cancer cells are the primary target, surrounding normal cells and tissues are also affected. Radiation toxicity is dose dependent, and tissue injury develops from inflammation that may progress to fibrosis. Thus, radiation dosing in cancer therapy is often limited by tissue toxicity. Although newer radiotherapeutic modalities aim to limit delivery of radiation to non-cancerous tissues, many patients continue to experience toxicity. Summary To ensure early recognition of radiation toxicity and fibrosis, it is imperative that all clinicians are aware of the predictors, signs, and symptoms of radiation fibrosis syndrome. Here, we present part 1 of the visceral complications of radiation fibrosis syndrome, addressing radiation-related toxicity in the heart, lungs, and thyroid gland. Graphical abstract

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Adolescents and Young Adults with Cancer: Survivorship and Special Considerations

Cited by 2 publications

References 36 publications

LGBTQI cancer patients’ quality of life and distress: A comparison by gender, sexuality, age, cancer type and geographical remoteness

LGBTQI cancer patients’ quality of life and distress: A comparison by gender, sexuality, age, cancer type and geographical remoteness

The Evaluation and Management of Visceral Complications in Radiation Fibrosis Syndrome Part 1

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