Adolescents with metabolic syndrome have a history of low aerobic fitness and physical activity levels

McMurray, Robert G.; Bangdiwala, Shrikant I.; Harrell, Joanne S.; Amorim, Leila Denise Alves Ferreira

doi:10.1186/1476-5918-7-5

Cited by 69 publications

(107 citation statements)

References 36 publications

(51 reference statements)

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“…Those with CMS had an adjusted Relative Risk (RR) of 1.46 for developing mobility limitations. The risk increased with higher central obesity and worse hyperglycemia [74,75].…”

Section: Lack Of Exercisementioning

confidence: 99%

Cardio Metabolic Syndrome: A Global Epidemic

Kelli¹,

Kassas²,

Lattouf

2016

J Diabetes Metab

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Cardio Metabolic Syndrome (CMS), also known as insulin resistance syndrome or metabolic syndrome X, is a combination of metabolic disorders or risk factors that essentially includes a combination of diabetes mellitus, systemic arterial hypertension, central obesity and hyper-lipidemia. Common to these diseases of metabolism is the associated development of atherosclerotic cardiovascular disease (ASCVD). Studies have shown a strong link between CMS and increased prevalence of peripheral vascular diseases, coronary artery disease and myocardial infarctions as well as cerebro-vascular arterial diseases and stroke.

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“…Those with CMS had an adjusted Relative Risk (RR) of 1.46 for developing mobility limitations. The risk increased with higher central obesity and worse hyperglycemia [74,75].…”

Section: Lack Of Exercisementioning

confidence: 99%

Cardio Metabolic Syndrome: A Global Epidemic

Kelli¹,

Kassas²,

Lattouf

2016

J Diabetes Metab

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“…In particular, six studies using objective measures of PA (that is, accelerometer) have found in healthy children an inverse relationship between PA level and metabolic risk factors, independent of age, gender and body mass index (BMI) or adiposity. [57][58][59][60][61][62] Overall, in overweight children a high fitness level was associated with a risk for MS similar to that of normal-weight children with a low fitness level, thus vanishing differences between body weight classes 21,50,[63][64][65] and contributing to long-term prevention. 66 The preventive role of PA in children was shown in a large study where a dose-response relationship between PA and blood pressure was found, and PA showed a strong effect on blood pressure when predicting hypertensive values.…”

Section: Physiopathological Basis Of the Msmentioning

confidence: 99%

Physical activity as the main therapeutic tool for metabolic syndrome in childhood

Brambilla¹,

Pozzobon

Pietrobelli

2010

Int J Obes

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Physical activity (PA) and diet directly influence obesity and metabolic syndrome (MS) as important determinants of body composition. Understanding how PA relates to MS in youth is of great importance, and could offer a common strategy for clinical and public health approaches to control this condition. The underlying disorder of MS is a condition of insulin resistance, and a strong relationship between PA level and insulin sensitivity is clearly ascertained. The type, duration, frequency and intensity of PA affect fuel metabolism, in particular carbohydrate and lipid oxidation. The possible modulation of metabolism because of increased fat oxidation by PA is the basis for both prevention and restoration of insulin resistance and MS in obese children. In daily clinical practice, diet followed by pharmacologic treatment are usually the approaches taken, whereas PA is often considered just a suggestion. Although diet and PA have different effects on body composition, with both contributing to fat loss, only PA increases muscle mass and thus has a direct effect on metabolic function, expressed by changes in cardiovascular risk factors. Therefore, it is important to remember their complementary but different targets in daily clinical practice, such as body weight control for diet and metabolic health for PA. In this review, we have summarized the literature on the relationship between PA and MS in pediatrics. Then, we have analyzed the possibility of using PA for MS treatment, as an alternative to drugs, by discussing the results of intervention studies, reasons for low compliance to PA, related benefits, adherence difficulties and costs. Finally, we have tried to suggest recommendations for a multiple-step PA strategy in children and adolescents at risk for MS, by considering PA as the 'key' player in treatment.

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“…In a longitudinal study by McMurray et al (53) , children with MetS (4?6 %) had lower PA levels and CRF outcomes than the non-MetS group. Some 4?25 % of prepubertal children in the current study presented MetS; these children belonged to the LCF group and did not perform PA. A similar percentage has been reported in another study of children (1) .…”

Section: Discussionmentioning

confidence: 94%

Non-traditional markers of metabolic risk in prepubertal children with different levels of cardiorespiratory fitness

Llorente-Cantarero

Pérez-Navero

Benítez-Sillero

et al. 2012

Public Health Nutr.

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Objective: To assess classical and non-classical metabolic risk biomarkers in prepubertal children with different levels of cardiorespiratory fitness (CRF). Design: CRF was assessed by the 20 m shuttle run test. To estimate physical activity, participants were observed while engaged in an after-school programme. Additionally, a short test based on a validated questionnaire was used to obtain information about physical activity practice and sedentary habits. Anthropometric parameters, blood pressure, and classical and non-traditional metabolic risk biomarkers -plasma lipid profile, glucose and insulin, homeostasis model assessment-insulin resistance index (HOMA-IR), plasma uric acid, transaminases and C-reactive protein (CRP) -were measured. Setting: The study was conducted in local elementary schools in Córdoba, Spain. Subjects: One hundred and forty-one healthy children (eighty-eight boys, fiftythree girls) aged 7-12 years, in Tanner stage I, were recruited. They were divided into two groups after they performed the 20 m shuttle run test: equal or higher cardiovascular fitness (EHCF) group and low cardiovascular fitness (LCF) group. Results: The LCF group displayed significantly higher TAG (P 5 0?004) and lower HDL cholesterol levels (P 5 0?001), as well as significantly lower values for the non-traditional lipid marker apo-A1 (P 5 0?001) compared with the EHCF group. The LCF children displayed higher plasma glucose (P 5 0?003) and insulin levels, higher HOMA-IR scores (P , 0?001) and higher plasma uric acid and CRP levels (P , 0?05). After adjustment for BMI, age and sex, no statistically significant differences were found between groups for the biomarkers analysed. Conclusions: The study provides new information to understand the role not only of weight status but also of the level of CRF on the metabolic health profile of prepubertal children. Keywords Physical fitness Physical activity Metabolic biomarkers ChildhoodThe metabolic syndrome (MetS) refers to the clustering of cardiovascular risk factors driven by peripheral insulin resistance. Data from recent studies involving a population of children and adolescents indicate that the prevalence of MetS varies between 3 % and 12 % (1)

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Adolescents with metabolic syndrome have a history of low aerobic fitness and physical activity levels

Cited by 69 publications

References 36 publications

Cardio Metabolic Syndrome: A Global Epidemic

Cardio Metabolic Syndrome: A Global Epidemic

Physical activity as the main therapeutic tool for metabolic syndrome in childhood

Non-traditional markers of metabolic risk in prepubertal children with different levels of cardiorespiratory fitness

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