Adolescents with type 1 diabetes can achieve glycemic targets on intensive insulin therapy without excessive weight gain

Marlow, A. L.; King, Bruce R.; Phelan, Helen; Smart, Carmel E.

doi:10.1002/edm2.352

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…However, this explanation is not supported by a recent Australian study in adolescents with T1D, which did not find any increase of BMI-SDS with the implementation of insulin therapy with more intensive schemes (multiple daily injection/CSII) ( 41 ). Similarly, a recent Italian study showed comparable body weight gain over a 10-year follow-up in T1D patients on CSII or multiple daily injection, despite improved glycemic control and decreased insulin doses with CSII ( 42 ).…”

Section: Discussionmentioning

confidence: 80%

The Burden of Obesity in Type 1 Diabetic Subjects: A Sex-specific Analysis From the AMD Annals Initiative

Giandalia,

Russo,

Ruggeri

et al. 2023

The Journal of Clinical Endocrinology &Amp; Metabolism

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Objective Obesity is a growing emergency also in type 1 diabetes (T1D). Sex-differences in obesity prevalence and its clinical consequences in adult T1D subjects have been poorly investigated. The aim of this study was to investigate the prevalence of obesity and severe obesity, clinical correlates and potential sex-differences in a large cohort of T1D subjects, participating to the AMD Annals Initiative in Italy. Research design and methods The prevalence of obesity (BMI ≥30 kg/m2) and severe obesity (BMI ≥ 35 kg/m2) according to sex and age, as well as obesity-associated clinical variables, long-term diabetes complications, pharmacological treatment, process indicators and outcomes, and overall quality of care (score Q) were evaluated in 37,436 T1D subjects (45.3% women) attending 282 Italian diabetes clinics during 2019. Results Overall, the prevalence of obesity was similar in the two gender (13.0% in men and 13.9% in women; mean age 50 years), and it increased with age, affecting 1 out of 6 subjects aged >65 years. Only severe obesity (BMI >35 Kg/m2) was more prevalent among women, who showed a 45% higher risk of severe obesity, compared with men at multivariate analysis. CVD risk factors (lipid profile, glucose and blood pressure control), and the overall quality of diabetes care were worse in obese subjects, with no major sex-related differences. Also, micro- and macrovascular complications were more frequent among obese than non-obese T1D men and women. Conclusions Obesity is a frequent finding in T1D adult subjects, and it is associated with a higher burden of CVD risk factors, micro- and macrovascular complications, and a lower quality of care, with no major sex-differences. T1D women are at higher risk of severe obesity.

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Section: Discussionmentioning

confidence: 80%

The Burden of Obesity in Type 1 Diabetic Subjects: A Sex-specific Analysis From the AMD Annals Initiative

Giandalia,

Russo,

Ruggeri

et al. 2023

The Journal of Clinical Endocrinology &Amp; Metabolism

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show abstract

“…This finding is in accordance with some [36,37], but not all [38], previous publications. With increased awareness of risks of weight gain and fat accumulation in patients on insulin, it is possible to reach near normoglycemia without weight gain regardless of method for insulin delivery [39].…”

Section: Discussionmentioning

confidence: 99%

Time-trends in body mass index, and overweight and obesity as independent risk factors for diabetes angiopathy in young females with type 1 diabetes – A nationwide study in Sweden

Haas,

Andersson Franko,

Lindholm Olinder

et al. 2023

Diabetes Research and Clinical Practice

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