ADP‐heptose enables <i>Helicobacter pylori</i> to exploit macrophages as a survival niche by suppressing antigen‐presenting HLA‐II expression

Coletta, Sara; Battaggia, Greta; Bella, Chiara Della; Furlani, Matteo; Hauke, Martina; Faass, Larissa; D’Elios, Mario Milco; Josenhans, Christine; Bernard, Marina de

doi:10.1002/1873-3468.14156

Cited by 11 publications

(6 citation statements)

References 27 publications

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“…( 133 . Translocation of heptosecontaining lipopolysaccharide core intermediates may be important in inducing pro-inflammatory responses by both epithelial and immune cells through the ALPK1-TIFA signalling pathway and may also induce mutagenic and oncogenic processes [134][135][136] . In addition, intracellular heptose signalling in macrophages may hamper antigen-presenting properties and subsequent T cell responses 136 .…”

Section: Bacterial Factors Involved In Colonization and Pathogenesismentioning

confidence: 99%

Helicobacter pylori infection

Malfertheiner

Camargo

El-Omar

et al. 2023

Nat Rev Dis Primers

317

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Helicobacter pylori infection causes chronic gastritis, which can progress to severe gastroduodenal pathologies, including peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. H. pylori is usually transmitted in childhood and persists for life if untreated. The infection affects around half of the population in the world but prevalence varies according to location and sanitation standards. H. pylori has unique properties to colonize gastric epithelium in an acidic environment. The pathophysiology of H. pylori infection is dependent on complex bacterial virulence mechanisms and their interaction with the host immune system and environmental factors, resulting in distinct gastritis phenotypes that determine possible progression to different gastroduodenal pathologies. The causative role of H. pylori infection in gastric cancer development presents the opportunity for preventive screen-and-treat strategies. Invasive, endoscopy-based and non-invasive methods, including breath, stool and serological tests, are used in the diagnosis of H. pylori infection. Their use depends on the specific individual patient history and local availability. H. pylori treatment consists of a strong acid suppressant in various combinations with antibiotics and/or bismuth. The dramatic increase in resistance to key antibiotics used in H. pylori eradication demands antibiotic susceptibility testing, surveillance of resistance and antibiotic stewardship.

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Section: Bacterial Factors Involved In Colonization and Pathogenesismentioning

confidence: 99%

Helicobacter pylori infection

Malfertheiner

Camargo

El-Omar

et al. 2023

Nat Rev Dis Primers

317

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“…Certain miRNAs may play a role in the bacterial infection’s ability to persist. Helicobacter pylori can upregulate miRNAs targeting CIITA, thereby suppressing HLAII expression on macrophages which plays a key role in the presentation of antigens to T lymphocytes ( Codolo et al, 2019 ; Coletta et al, 2021 ). After an H. pylori infection, macrophages regulate the release of proinflammatory cytokines via the increased expression of miR-155 ( Yao et al, 2015 ).…”

Section: Molecular Mechanisms Involved In Bacterial-driven Macrophage...mentioning

confidence: 99%

Bacteria and macrophages in the tumor microenvironment

Xiong²,

Fu³

et al. 2023

Front. Microbiol.

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Cancer and microbial infections are significant worldwide health challenges. Numerous studies have demonstrated that bacteria may contribute to the emergence of cancer. In this review, we assemble bacterial species discovered in various cancers to describe their variety and specificity. The relationship between bacteria and macrophages in cancer is also highlighted, and we look for ample proof to establish a biological basis for bacterial-induced macrophage polarization. Finally, we quickly go over the potential roles of metabolites, cytokines, and microRNAs in the regulation of the tumor microenvironment by bacterially activated macrophages. The complexity of bacteria and macrophages in cancer will be revealed as we gain a better understanding of their pathogenic mechanisms, which will lead to new therapeutic approaches for both inflammatory illnesses and cancer.

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“…Hence, antigen presentation ability is decreased, leading to persistent H. pylori infection ( 28 ). The upregulation of let-7i-5p, miR-146b-5p and miR-185-5p, and miR146b expression in macrophages caused by H. pylori infection can similarly decrease HLA-II expression on the plasma membrane, which ultimately compromises bacterial antigen presentation to Th lymphocytes and impairs immune responses against H. pylori ( 29 , 30 ). Collectively, H. pylori infection mainly downregulates surface recognition factors at the transcriptional level by rendering macrophages fail to degrade the bacteria.…”

Section: Effects Of H Pylori On Tumor Stromal Cell...mentioning

confidence: 99%

Effects of helicobacter pylori on tumor microenvironment and immunotherapy responses

et al. 2022

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Helicobacter pylori is closely associated with gastric cancer. During persistent infection, Helicobacter pylori can form a microenvironment in gastric mucosa which facilitates the survival and colony formation of Helicobacter pylori. Tumor stromal cells are involved in this process, including tumor-associated macrophages, mesenchymal stem cells, cancer-associated fibroblasts, and myeloid-derived suppressor cells, and so on. The immune checkpoints are also regulated by Helicobacter pylori infection. Helicobacter pylori virulence factors can also act as immunogens or adjuvants to elicit or enhance immune responses, indicating their potential applications in vaccine development and tumor immunotherapy. This review highlights the effects of Helicobacter pylori on the immune microenvironment and its potential roles in tumor immunotherapy responses.

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ADP‐heptose enables Helicobacter pylori to exploit macrophages as a survival niche by suppressing antigen‐presenting HLA‐II expression

Cited by 11 publications

References 27 publications

Helicobacter pylori infection

Helicobacter pylori infection

Bacteria and macrophages in the tumor microenvironment

Effects of helicobacter pylori on tumor microenvironment and immunotherapy responses

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