ADRB2 Gln27Glu polymorphism influenced changes in leptin but not body composition or metabolic and other inflammatory parameters after twelve weeks of combined training in overweight adolescents

Abstract

-Aim:To compare the anthropometric, metabolic, and inflammatory parameters of overweight adolescents after 12-weeks of resistance and aerobic training (CT), taking into account the Gln27Glu polymorphism of the β2 adrenergic receptor (ADRB2) gene. Methods: Forty-seven adolescents (15.05±1.07y) were assigned to one of four groups, according to the presence or absence of the Glu27 allele: CT (CarrierT n=11; NoncarrierT n=11) or control (CarrierC n=13; NoncarrierC n=12). Body composition, abdominal fat, maturation, fitness, metabolic and lipid profile, inflammatory markers were assessed. The CT consisted of six resistance exercises, followed by 30 min of walking/ running at 50-80% VO 2max , totaling 60 min/session, three times a week. A mixed-model factorial ANOVA was used to compare variables at baseline and after 12-weeks. Results: TC was effective in reducing total fat mass (NoncarrierT ES=.45, CarrierT ES=.27) and subcutaneous abdominal fat (NoncarrierT ES=.48, CarrierT ES=.46) and increasing lean mass (NoncarrierT ES=.58, CarrierT ES=.60) and fitness. CarrierT group showed a reduction in leptin (ES=.49). Conclusion:The responses of body composition and physical fitness to TC were not influenced by the presence of the Gln27Glu polymorphism. However, only the Glu27 allele carriers showed reductions in leptin after 12-weeks. Besides, a lack of intervention caused obesogenic effects, especially in Glu27carriers.

Effects and Responsiveness of a Multicomponent Intervention on Body Composition, Physical Fitness, and Leptin in Overweight/Obese Adolescents

“…However, Lau et al [ 30 ] did not show weight loss and decreased leptin levels in obese adolescents after physical training. Such divergent findings may be due to different exercise patterns and durations, the participants’ nutritional status, physical activity, leptin circadian rhythm, or the presence of genetic polymorphisms [ 31 ].…”

The Genetic Basis of Childhood Obesity: A Systematic Review

“…A total of 27 studies [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ], 26 non-randomized control studies and 1 randomized control trial were analyzed, consisting of 7928 overweight/obese children and adolescents within the age range of 4.5–20 years who were at different stages of pubertal development. The interventions took place in ten countries (Brazil, Poland, China, USA, Germany, Denmark, Spain, Italy, Portugal, and Czechia), representing a variety of populations.…”

Adrb2 Gln27glu Polymorphism Associated With Adiposity Indicators and Il-10 in Adolescents

“…The maximal oxygen consumption (VO 2max ) and the maximum peak oxygen consumption (VO 2peak ) were measured on the X-Fit 7 Power treadmill using the portable gas analyzer K4b2® (Cosmed, Italy) and a ramp protocol previously described. 12 The test was considered maximum when two of the following criteria were observed: a) exhaustion or inability to maintain required speed; b) R ≥ 1,09; c) maximum heart rate (HR) predicted by the formula 208 -(0.7 x age), proposed by Tanaka. 20 The muscle strength was estimated based on the load obtained in the test of a maximum repetition (1RM), conducted according to the protocol proposed by Brown & Weir.…”

“…6 The 27Glu allele was associated with several cardiometabolic risk factors, such as overweight and body fat distribution in adolescents 7 and adults 8,9 , rates of maximum fat oxidation 10 , energy expenditure and exercise. 11,12 Additionally, a recent study pointed to higher concentrations of leptin in 27Glu allele carriers 13 , which suggests a possible association between this adipokine and the Gln27Glu ADRB2 polymorphism. This relationship may play a key role in proinflammatory states enhancement induced by stressed adipocytes presence in response to lipid overload.…”