Adrenal gland volume assessed by magnetic resonance imaging in women with polycystic ovary syndrome

Ünlü, Ebru; Ünlü, Bekir Serdar; Yıldız, Yunus; Beker‐Acay, Mehtap; Kaçar, Emre; Turamanlar, Ozan; Tulmaç, Özlem Banu; Seven, Ali; Özuğuz, Ufuk

doi:10.1016/j.diii.2015.02.004

Cited by 9 publications

(4 citation statements)

References 36 publications

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“…Distinguishing between these sources is clinically relevant, as it may influence treatment choices and prognosis. Additionally, recent studies utilizing advanced imaging techniques have shown that adrenal morphology and function are altered in PCOS, suggesting a more significant role of adrenal-derived androgens than previously understood [30]. Beyond ovarian and adrenal output, key additional contributions come from the conversion of DHEA to androstenedione, androstenedione to testosterone, and testosterone to dihydrotestosterone within adipose tissue, augmenting the pool of circulating androgens.…”

Section: Pathophysiology Of Androgen Excessmentioning

confidence: 99%

The Current and Emerging Role of Statins in the Treatment of PCOS: The Evidence to Date

Kolnikaj,

Herman,

Janež

et al. 2024

Medicina

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Polycystic ovary syndrome (PCOS) manifests a multifactorial pathology characterized by polycystic ovaries, menstrual cycle disorders, varying degrees of hyperandrogenism, and an ad-verse metabolic risk profile. The position of hyperandrogenism in this syndrome has been extensively studied. A multitude of mechanisms place it in the position of cause but also of consequence; therefore, ongoing research efforts are focused on identifying medications that can effectively reduce levels of androgens in women with PCOS. Moreover, lipid abnormalities are common in this population, with up to 70% of patients having dyslipidemia. Statins may have potential therapeutic benefits for women with PCOS, as they have been shown to improve insulin resistance and reduce the risk of cardiovascular disease. In addition, their role in accelerated steroidogenesis by limiting one source of cholesterol, influencing enzymatic activity, and providing several other beneficial mechanisms is widely investigated. This review aimed to provide a comprehensive overview of the pathogenesis of androgen excess and dyslipidemia in PCOS, as well as the therapeutic potential of statins.

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Section: Pathophysiology Of Androgen Excessmentioning

confidence: 99%

The Current and Emerging Role of Statins in the Treatment of PCOS: The Evidence to Date

Kolnikaj,

Herman,

Janež

et al. 2024

Medicina

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“… 10 The adrenal excess in PCOS and its clinical severity are in correlation with adrenal volume increase, that is almost 50%. 24 Obesity could be a very powerful contributing factor, or even the only cause of androgen excess. This could be the explanation of the fact that even in the absence of ovarian androgen excess, the adrenal or even peripheral androgen excess and IR are the reasons of anovulation and polycystic ovarian morphology.…”

Section: Hormonal and Molecular Basis Of Dysmetabolic Infertilitymentioning

confidence: 99%

“…About two‐thirds of PCOS cases have typical functional ovarian hyperandrogenism, in one‐third of PCOS it is functionally atypical, and a small number are due to isolated functional andrenal hyperandrogenism or overlap between functional ovarian and adrenal androgen excess 10 . The adrenal excess in PCOS and its clinical severity are in correlation with adrenal volume increase, that is almost 50% 24 . Obesity could be a very powerful contributing factor, or even the only cause of androgen excess.…”

Section: Hormonal and Molecular Basis Of Dysmetabolic Infertilitymentioning

confidence: 99%

Female infertility in the era of obesity: The clash of two pandemics or inevitable consequence?

Medenica

Spoltore

Ormazábal

et al. 2022

Clinical Endocrinology

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Obesity is an epidemic that has led to a rise in the incidence of many comorbidities: among others, reduced fertility is often under-evaluated in clinical practice. The mechanisms underlying the link between reduced fertility and obesity are numerous, with insulin resistance, hyperglycaemia and the frequent coexistence of polycystic ovary syndrome being the most acknowledged. However, several other factors concur, such as gut microbiome alterations, low-grade chronic inflammation and oxidative stress. Not only do women with obesity take longer to conceive, but in vitro fertilization (IVF) is also less likely to succeed. We herein provide an updated state-of-the-art regarding the molecular bases of what we could define as dysmetabolic infertility, focusing on the clinical aspects, as well as possible treatment.

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“…1) was performed on venous phase CT images using a combination of contour drawing, thresholding and region growing. Interpolation between the marked slices was performed semi-automatically using a linear algorithm [20,21]. The splenic, mesenteric and hepatic arteries, celiac trunk, splenic vein, and the superior mesenteric vein were excluded from pancreatic segmentation.…”

Section: Pancreas Volumementioning

confidence: 99%

Patients with type 2 diabetes present with multiple anomalies of the pancreatic arterial tree on abdominal computed tomography: comparison between patients with type 2 diabetes and a matched control group

Alexandre‐Heymann

Barral

Dohan

et al. 2020

Cardiovasc Diabetol

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Background: Studies suggest that cardio-vascular risk factors could foster the development of type 2 diabetes (T2D). This could partly be mediated by pancreatic atherosclerosis resulting in pancreatic ischemia. We hypothesized that patients with T2D present with more severe atherosclerosis of pancreas-bound arteries than control patients without T2D. Methods: We performed a retrospective study comparing the abdominal computed tomography of patients with T2D and of control subjects matched for gender and for age. We performed a multivariate logistic regression with adjustment for age, gender, BMI and the presence or absence of hypertension. Results: Forty-eight patients with T2D and 48 control subjects were included. A calcification score of the splenic artery was defined (from 0: no calcification to 3: continuous linear calcifications). Seventeen percent of the patients with T2D presented with a high calcification score (i.e. 2 or 3), versus only 2% of the control subjects (p = 0.04). The mean number of pancreas-bound branches among the greater pancreatic artery, dorsal pancreatic artery and inferior pancreatic artery (from 0 to 3) was lower in patients with T2D than in control subjects (1.1 vs 1.7, p = 0.003). The mean number of visible intrapancreatic arterial subdivisions (from 0 to 2) was lower in patients with T2D than in control subjects (0.7 vs 1.3, p = 0.0017). All these differences hold true using multivariate logistic regression. None of these differences correlated with the duration of diabetes. The relationship between pancreas volume and BMI seen in control subjects was not confirmed in patients with T2D. Conversely, in patients with T2D but not in control subjects, the splenic artery diameter correlated with the pancreas volume. Conclusions: Patients with T2D present with more calcifications of the splenic artery and with a less dense pancreatic arterial tree than control subjects.

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Adrenal gland volume assessed by magnetic resonance imaging in women with polycystic ovary syndrome

Cited by 9 publications

References 36 publications

The Current and Emerging Role of Statins in the Treatment of PCOS: The Evidence to Date

The Current and Emerging Role of Statins in the Treatment of PCOS: The Evidence to Date

Female infertility in the era of obesity: The clash of two pandemics or inevitable consequence?

Patients with type 2 diabetes present with multiple anomalies of the pancreatic arterial tree on abdominal computed tomography: comparison between patients with type 2 diabetes and a matched control group

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