Adrenal Myelolipoma Simulating Virilizing Adrenal Tumor

Moskovitz, Boaz; Bolkier, M; Katz, Yeshayahu; Arieh, Yehudith Ben; Levin, Daniel

doi:10.1159/000281453

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…According to that theory, AML may be secondary to prolonged stress and continuous stimulation by adrenocorticotropic hormon and/or androgens or cortisol (which may be associated with endocrine disorders, such as hermaphrodism, Cushing's disease, Addison's disease or obesity of uncertain etiology, or may be exogenic by continuous administration of progesterone or other hormones) [12,[17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

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Bilateral Giant Adrenal Myelolipoma and Polycystic Ovarian Disease

Kalafatis¹

1999

Urol Int

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We report a case of a nonfunctioning, synchronous, bilateral, very large adrenal myelolipoma in an obese woman. She had diabetes mellitus and oligomenorrhea due to polycystic ovarian disease, and for that, she was taking progesterone medication for over 12 years. The principal clinical findings, the etiology and pathogenesis, the diagnostic-tools including US-guided fine-needle biopsy to preoperative differential diagnosis, are discussed.

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Section: Discussionmentioning

confidence: 99%

“…AMLS are rarely combined with Cushing's disease [10,13], Conn syndrome [18], 17-or 21-hydroxylase deficiency [11,19]. It can also simulate virilizing adrenal tumor or pheochromocytoma [20,21].…”

Section: Kalafatismentioning

confidence: 99%

Bilateral Giant Adrenal Myelolipoma and Polycystic Ovarian Disease

Kalafatis¹

1999

Urol Int

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“…They include Conn's syndrome and Cushing's syndrome, due to co-existing adrenal hyperplasia possibly combined to bilateral adrenal calcification [14,[17][18][19]. The endocrine activity may reside within the myelolipoma tissue, thus lending a functional component to it [19][20][21]. Foci of myelolipoma were identified within an aldosterone-producing adenoma [22].…”

Section: Introductionmentioning

confidence: 99%

Complete Sequencing and mRNA Expression Analysis of the MEN-I Gene in Adrenal Myelolipoma

Schulte¹,

Heinze²,

Mengel³

et al. 2000

Horm Metab Res

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The molecular pathogenesis of adrenal myelolipoma is unclear. Endocrine activity of these tumors and association with other endocrine tumors have stimulated the hypothesis that it may belong to the group of sporadic tumors caused by defects of the gene responsible for multiple endocrine neoplasia type I (MEN-I). DNA of blood and tumoral sections from two patients with adrenal myelolipoma were analyzed by examination of variable number of tandem repeats (VNTR) loci PYGM, D11S987, D11S480, and D11S449 on chromosome 11q13 and by complete direct DNA sequencing of all coding exons and splice junctions of the MEN-I gene. Menin expression was examined by RT-PCR. RT-PCR did not detect menin expression in one adrenal myelolipoma. No loss of heterozygozity on chromosome 11q13 was identified. Intragenic heterozygozity was retained in codon 418 of the menin gene in both patients. No mutation was identified in the coding exons of the menin gene. Complete DNA sequencing yielded no hint that defects of the MEN-I gene are responsible for the formation of adrenal myelolipomas. Adrenal myelolipomas do not share the loss of heterozygozity on chromosome 11q13 observed in some benign adenomatous and many malignant adrenocortical tumors.

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Adrenal myelolipoma with hyperandrogenemia and schizophrenia

Liu

Wen-hua

Tan

et al. 2018

CMAR

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Adrenal myelolipoma with hyperandrogenemia is extremely rare. We report a case of a 26-year-old Chinese female with schizophrenia, who presented with a hormonally active tumor causing hyperandrogenemia. The mass was found by computerized tomography when she had her gynecologic examination for secondary amenorrhea, and it was confirmed to be an adrenal myelolipoma after a histopathological study. She was referred for a left adrenal laparoscopic excision, and the size of adrenal myelolipoma was found to be more than 10 cm. We report this case because large adrenal myelolipomas with hyperandrogenemia and schizophrenia are rare, and adrenal myelolipoma associated with hyperandrogenemia might be determined by the enzymes involved in the production of hormones.

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Adrenal Myelolipoma Simulating Virilizing Adrenal Tumor

Cited by 3 publications

References 6 publications

Bilateral Giant Adrenal Myelolipoma and Polycystic Ovarian Disease

Bilateral Giant Adrenal Myelolipoma and Polycystic Ovarian Disease

Complete Sequencing and mRNA Expression Analysis of the MEN-I Gene in Adrenal Myelolipoma

Adrenal myelolipoma with hyperandrogenemia and schizophrenia

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