1972
DOI: 10.1530/acta.0.069s0005
|View full text |Cite
|
Sign up to set email alerts
|

Adrenalectomy in Cushing's Disease

Abstract: SUMMARY Forty-four patients with Cushing's disease underwent bilateral adrenalectomy and 39 survivors were followed for, on an average, eight years and a half. There were three postoperative deaths and two other patients died within one year after operation. Thirty patients are now working but six remain invalidized. In four subjects cortisol secretion persisted in spite of "total" adrenalectomy but a clinical remission ultimately occurred. Five patients, who presented with an atypical clinical picture… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
16
0

Year Published

1973
1973
2004
2004

Publication Types

Select...
4
4

Relationship

0
8

Authors

Journals

citations
Cited by 34 publications
(17 citation statements)
references
References 0 publications
1
16
0
Order By: Relevance
“…The complications related to the Nelson's syndrome are essentially due to the tumoral volume: chiasmatic compression with visual field loss, either transitory or definitive is the most frequent complication described, with a prevalence ranging from 1/10 to 4/9 [24,30,32,35,37,38,45,47,[49][50][51][52]. Occulomotor nerve palsy has also been described [49], as well as tumor necrosis with sudden intracranial hypertension [35,51].…”
Section: Complicationsmentioning
confidence: 99%
See 1 more Smart Citation
“…The complications related to the Nelson's syndrome are essentially due to the tumoral volume: chiasmatic compression with visual field loss, either transitory or definitive is the most frequent complication described, with a prevalence ranging from 1/10 to 4/9 [24,30,32,35,37,38,45,47,[49][50][51][52]. Occulomotor nerve palsy has also been described [49], as well as tumor necrosis with sudden intracranial hypertension [35,51].…”
Section: Complicationsmentioning
confidence: 99%
“…Occulomotor nerve palsy has also been described [49], as well as tumor necrosis with sudden intracranial hypertension [35,51]. Cases of diabetes insipidus [5] and hypopituitarism are exceptional.…”
Section: Complicationsmentioning
confidence: 99%
“…Pre-.vious literature defines Nelson's syndrome somewhat differently. Some investigators regard hyperpigmentation as important for diagnosis [3,23], whereas others require both hyperpigmentation and sellar enlargement for definite diagnosis [8,29,41]. If one follows the original description of the disease by Nelson et al [35], the diagnostic criteria of Nelson's syndrome will include a demonstrable ACTHhypersecreting pituitary adenoma with sellar enlargement, visual disturbances and increased cutaneous pigmentation that developed after bilateral adrenalectomy for Cushing's disease.…”
Section: Clinical Features Of Nelson's Syndromementioning
confidence: 99%
“…Although it is estimated by the previous literature [8,10,13,15,16,20,28,32,37,39,46,54] that 5 to 20% of adrenalectomized Cushing patients will develop pituitary tumours, the true prevalence has been unclear. The relatively low incidence of detecting Nelson's adenoma in the past is solely due to the lack of precise neurodiagnostic techniques, taking only symptomatic macroadenomas.…”
Section: Incidence Of Nelson's Syndromementioning
confidence: 99%
“…Postoperative replacement therapy, appropriately increased during labor or caesarean section [39], allowed gestation and delivery to proceed uneventfully [25,27]. In this context it is worth recalling the considerable number of women cured from Cushing's disease by bilateral adrenalectomy, as was the custom in the past [44], in whom pregnancy was carried to term without mishap.…”
Section: Treatment Of Cushing's Disease During Pregnancymentioning
confidence: 99%