Adrenocortical hormones, ageing and mental condition: seasonal and circadian rhythms of plasma 18-hydroxy-11-deoxycorticosterone, total and free cortisol and urinary corticosteroids

Touitou, Yvan; Sulon, J.; Bogdan, André; Reinberg, A; Sodoyez, Jean-Claude; Demey-Ponsart, E.

doi:10.1677/joe.0.0960053

Cited by 100 publications

(44 citation statements)

References 9 publications

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“…the nadir and the 24 h mean are modified, cortisol rhythm is not altered by various factors, e.g. sex and aging (Touitou et al, 1982(Touitou et al, , 1983. The changes in the secretory pattern of serum cortisol reported here suggest a dramatic rhythm modification: eight out of the 13 breast cancer patients (53%) had abnormal patterns of the hormone with, e.g.…”

Section: Resultsmentioning

confidence: 65%

“…Independently of the distinct circadian peak coincident with the beginning of the organism's activity cycle, another low-amplitude circadian peak may be apparent in some individuals, following the midday meal and located in the early afternooon (Quigley and Yen, 1982;Follenius et al, 1982). Cortisol is therefore considered as a strong oscillator, and thus as a marker of the circadian rhythmicity in man (Touitou et al, 1982(Touitou et al, , 1983. Indeed, except for endocrine diseases, such as Cushing's syndrome, in which the circadian rhythm of cortisol is dramatically disrupted, and psychiatric diseases, such as depression, in which cortisol rhythm is present, although some of its parameters, e.g.…”

Section: Resultsmentioning

confidence: 99%

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Disruption of the circadian patterns of serum cortisol in breast and ovarian cancer patients: relationships with tumour marker antigens

Touitou

Bogdan²,

Lévi³

et al. 1996

Br J Cancer

126

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Summary Few data are available on the circadian rhythmicity in cancer patients. Since monitoring the disease usually implies the follow-up of blood concentrations of a number of biological variables, it would be of value to examine the profile of the circadian variations of serum cortisol and tumour marker antigens. This we did in 33 cancer patients (13 breast cancer patients and 20 ovarian cancer patients). The profiles of serum cortisol were documented, since this hormone is considered as a strong marker of circadian rhythms. This study shows that 8 out of 13 breast cancer patients and 15 out of 20 ovarian cancer patients had deeply altered cortisol circadian patterns. The modifications were either high levels along the 24 h scale and/or erratic peaks and troughs and/or flattened profiles. Within 24 h, variations of tumour marker antigens as large as 70% were observed but no typical individual circadian patterns could be found. No relationship between cortisol subgroups and concentration of tumour marker antigens at 8 h could be observed (Kolmogorov-Smirnov's test). The question thus arises as to the origin of these alterations, and whether they are related to a cause or a consequence of the disease, and their possible incidence upon therapeutic designs.

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Section: Resultsmentioning

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Disruption of the circadian patterns of serum cortisol in breast and ovarian cancer patients: relationships with tumour marker antigens

Touitou

Bogdan²,

Lévi³

et al. 1996

Br J Cancer

126

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“…Numerous studies have reported that diurnal rhythmicity of cortisol [254,257,[269][270][271][272][273][274][275][276][277][278][279][280] and ACTH [238,263] is also unaffected by aging in both sexes, but there are some exceptions. For example, some studies reported higher evening [251,281] and morning [278] cortisol levels at older ages; higher 24h mean cortisol concentrations at older ages have also been reported in both men and women [269,270,272,281,282].…”

Section: Humansmentioning

confidence: 99%

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Zaidi¹

2013

TOLSJ

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Steroid hormones are lipophilic, low-molecular weight organic compounds all of which are derived from cholesterol. They are primarily synthesized by steroidogenic glands such as gonads (ovary and testis), the adrenal gland and, during pregnancy, by the placental trophoblasts. Limited steroid synthesis also takes place in the brain. Steroid hormones are crucial for the proper functioning of the body. They mediate a wide variety of vital physiological functions, ranging from maintaining normal reproductive function and secondary sexual characteristics, to regulating virtually every metabolic process in the body. Like many age-related endocrine disorders, aging also progressively impacts the tissue-specific synthesis and secretion of steroid hormones. The goal of this review is to summarize the effects of aging on steroid hormone synthesis and secretion by the adrenal gland and gonads of both human and experimental animal models, to describe the potential involvement of excessive oxidative stress in mediating age-related alterations in steroidogenesis, and to discuss the possible underlying mechanisms involved.

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“…The urine collection was performed during a defined period of the year (June/July) in order to exclude all seasonal changes in urinary hormone excretion [33]. Participants were asked to collect their noc turnal urine over a period of 5 consecutive nights at their homes between 10 p.m. and 8 a.m.…”

Section: Questionnaire Measures and Collection O F Urine Samplesmentioning

confidence: 99%

Endocrine Correlates of Personality Traits: A Comparison between Emotionally Stable and Emotionally Labile Healthy Young Men

Adler¹,

Wedekind²,

Pilz³

et al. 1997

Neuropsychobiology

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An initial sample of 120 healthy young men was screened by a personality questionnaire and 15 subjects each with highest and lowest scores respectively on emotionality (emotionally labile, EL subjects and emotionally stable, ES subjects) were recruited for a study on the relationship between the degree of emotionality and the basal secretion of stress-sensitive hormones during nighttime. The nocturnal urinary excretion of cortisol, testosterone, adrenaline, noradrenaline and melatonin was measured over a period of 5 consecutive nights. The average amounts of each hormone excreted per night were not different between the two extreme groups. The variability of the excretion during the 5 nights of cortisol and testosterone, but not of adrenaline, noradrenaline and melatonin, was significantly higher in EL compared to ES subjects. The larger fluctuations in the nocturnal secretion of these two (and no other) hormones in EL subjects indicate that emotional lability is associated with a more labile regulation of cortisol and testosterone secretion. The observed intraindividual variability of basal stress hormone secretion may contribute to the vast interindividual variability noticed in psychoneuroendocrine stress research, especially in emotionally labile subjects.

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Adrenocortical hormones, ageing and mental condition: seasonal and circadian rhythms of plasma 18-hydroxy-11-deoxycorticosterone, total and free cortisol and urinary corticosteroids

Cited by 100 publications

References 9 publications

Disruption of the circadian patterns of serum cortisol in breast and ovarian cancer patients: relationships with tumour marker antigens

Disruption of the circadian patterns of serum cortisol in breast and ovarian cancer patients: relationships with tumour marker antigens

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Endocrine Correlates of Personality Traits: A Comparison between Emotionally Stable and Emotionally Labile Healthy Young Men

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