2003
DOI: 10.1291/hypres.26.s61
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Adrenomedullin, an Autocrine Mediator of Blood-Brain Barrier Function

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Cited by 40 publications
(23 citation statements)
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References 131 publications
(169 reference statements)
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“…AM has a known ability to regulate its receptor components [26], hence CLR, RAMP2 and RAMP3 production in primary human CD3 + T cells was investigated following 24 h treatment with AM. Considering increased AM levels during inflammation [13,32] and hypoxia conditions [17,27], a pathological concentration of 10 − 6 M was selected in line with previous experiments on the blood-brain barrier [33] and cerebral endothelia cells [1]. Our study revealed a modest activationdependent down-regulation of RAMP2 (PHA+/cell surface) and RAMP3 (PHA-/internal) following exposure to AM.…”
Section: Discussionmentioning
confidence: 77%
“…AM has a known ability to regulate its receptor components [26], hence CLR, RAMP2 and RAMP3 production in primary human CD3 + T cells was investigated following 24 h treatment with AM. Considering increased AM levels during inflammation [13,32] and hypoxia conditions [17,27], a pathological concentration of 10 − 6 M was selected in line with previous experiments on the blood-brain barrier [33] and cerebral endothelia cells [1]. Our study revealed a modest activationdependent down-regulation of RAMP2 (PHA+/cell surface) and RAMP3 (PHA-/internal) following exposure to AM.…”
Section: Discussionmentioning
confidence: 77%
“…cAMP is an autocrine mediator which maintains the intraendothelial cyclic cAMP levels, and it is also known to be a critical regulator of BBB (Kis et al, 2003a).…”
Section: Discussionmentioning
confidence: 99%
“…The AM gene is thus expressed in and the peptide is released by various cells and it is thus considered to play a pathological role in cerebrovascular and cardiovascular diseases Fujioka et al, 2000;Terata et al, 2000;Kastin et al, 2001;Wijdicks et al, 2001;Kis et al, 2001aKis et al, ,b, 2002Kis et al, , 2003aSerrano et al, 2002;Kato et al, 2003;Tahan et al, 2003;Fernandez-Sauze et al, 2004;Hayashi et al, 2004;Nagoshi et al, 2004;Suzuki et al, 2004). AM is also secreted from cultured rat brain microvascular endothelial cells (BMEC) and its production is stimulated by astrocyte-derived factors (Kis et al, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…To increase junctional integrity, we used adrenomedullin and the cAMP analog 8-pCPT-29-O-Me-cAMP (O-Me). Whereas adrenomedullin is a crucial autocrine and paracrine hormone mediator of blood-brain-barrier junctional tightness (Kis et al, 2003), O-Me acts downstream of adrenomedullin by directly stimulating the guanine nucleotide exchange factor EPAC-1 (also known as RAPGEF3), which, in turn, activates the small GTPase Rap-1 and, ultimately, Rac-1 (Bos, 2003;Spindler et al, 2010). Addition of adrenomedullin or O-Me to rat brain endothelium led to a ,15% enhancement in the already high (,77 Vcm 2 ) resistance ( Fig.…”
Section: Introductionmentioning
confidence: 99%