Adropin Is a Brain Membrane-bound Protein Regulating Physical Activity via the NB-3/Notch Signaling Pathway in Mice

Wong, Chi Ming; Wang, Yudong; Lee, Jimmy Tsz Hang; Huang, Zengshu; Wu, Donghai; Xu, Aimin; Lam, Karen Siu Ling

doi:10.1074/jbc.m114.576058

Cited by 106 publications

(114 citation statements)

References 38 publications

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“…Adropin is encoded by the Energy Homeostasis Associated (Enho) gene that is widely expressed in the central nervous system, as well as peripheral tissues such as liver, the heart and skeletal muscles [14][15][16]. While the mechanism of release remains controversial, the rapid regulation according to energy and nutritional status has been observed.…”

Section: Discussionmentioning

confidence: 99%

First and third trimester serum concentrations of adropin and copeptin in gestational diabetes mellitus and normal pregnancy

Dąbrowski

Jarmużek²,

Gondek³

et al. 2016

Ginekol Pol

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Objectives: Gestational diabetes mellitus (GDM) is a metabolic disease diagnosed in 1.7% up to 11.6% pregnancies. The prevalence of adverse pregnancy outcome is significantly higher in the case of early onset of diabetes mellitus. Adropin is a hormone promoting carbohydrate oxidation over fat oxidation, and influence nitric oxide synthase. Copeptin is a cleavage product of the vasopressin precursor recently correlated with diabetes mellitus. The aim of the study was to determine maternal serum adropin and copeptin concentrations in women with early and late manifestation of GDM and to discuss their potential role as biochemical markers of insulin resistance. Material and methods:Case-control study on 58 pregnant Caucasian women. Serum levels of adropin and copeptin were assessed in patients with early onset (GDM1) and classical gestational diabetes mellitus (GDM2). Complications such as macrosomia and hypotrophy were evaluated. Results:There was no significant difference between the study and the control group (age, BMI, parity). Fetal growth disturbance rate was 37.5% in GDM1, 11% in GDM2 and 6% in controls. Adropin concentration in GDM patients was significantly higher than in control group (p < 0.001), but there was no difference between GDM1 and GDM2 group. High serum concentration of adropin positively correlated with elevated HbA 1c (p < 0.05). The groups did not differ in terms of copeptin serum concentration. Conclusions:High adropin serum concentration in GDM patients is associated with increased risk of fetal growth disturbances, possibly due to improper placentation. According to our prospective study, neither copeptin nor adropin serum concentration are useful to discriminate between early and late onset of gestational diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

First and third trimester serum concentrations of adropin and copeptin in gestational diabetes mellitus and normal pregnancy

Dąbrowski

Jarmużek²,

Gondek³

et al. 2016

Ginekol Pol

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“…However, the source of the exercise training-induced increase in serum adropin levels remains unclear. Adropin is expressed in vascular endothelial cells, as well as in brain, heart, kidney, liver, pancreas, skeletal muscle, and small intestine (2,32). An in vitro study showed that adropin treatment promotes NO production from the human umbilical vein endothelial cells in a time-dependent manner, mediated via phosphorylation of eNOS protein (20).…”

Section: Discussionmentioning

confidence: 99%

“…Adropin consists of 76 amino acids and is encoded by a gene, Energy Homeostasis Associated (Enho) (16), and expressed in multiple tissues, including the brain, heart, kidney, liver, pancreas, skeletal muscle, and small intestine (2,32). Circulating adropin level decreases with age (7).…”

mentioning

confidence: 99%

Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults

Fujie

Hasegawa

Sato

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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Fujie S, Hasegawa N, Sato K, Fujita S, Sanada K, Hamaoka T, Iemitsu M. Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults. Am J Physiol Heart Circ Physiol 309: H1642-H1647, 2015. First published September 14, 2015; doi:10.1152/ajpheart.00338.2015.-Aging-induced arterial stiffening is reduced by aerobic exercise training, and elevated production of nitric oxide (NO) participates in this effect. Adropin is a regulator of endothelial NO synthase and NO release, and circulating adropin level decreases with age. However, the effect of habitual aerobic exercise on circulating adropin levels in healthy middleaged and older adults remains unclear. We sought to determine whether serum adropin level is associated with exercise training-induced changes in arterial stiffness. First, in a cross-sectional study, we investigated the association between serum adropin level and both arterial stiffness and cardiorespiratory fitness in 80 healthy middle-aged and older subjects (65.6 Ϯ 0.9 yr). Second, in an intervention study, we examined the effects of 8-wk aerobic exercise training on serum adropin level and arterial stiffness in 40 healthy middle-aged and older subjects (67.3 Ϯ 1.0 yr) divided into two groups: aerobic exercise training and sedentary controls. In the cross-sectional study, serum adropin level was negatively correlated with carotid ␤-stiffness (r ϭ Ϫ0.437, P Ͻ 0.001) and positively correlated with plasma NOx level (r ϭ 0.493, P Ͻ 0.001) and cardiorespiratory fitness (r ϭ 0.457, P Ͻ 0.001). Serum adropin levels were elevated after the 8-wk aerobic exercise training intervention, and training-induced changes in serum adropin level were correlated with traininginduced changes in carotid ␤-stiffness (r ϭ Ϫ0.399, P Ͻ 0.05) and plasma NOx level (r ϭ 0.623, P Ͻ 0.001). Thus the increase in adropin may participate in the exercise-induced reduction of arterial stiffness. ARTERIAL STIFFNESS increases with age (26) owing to declines in endothelial function and autonomic function and increases in arterial wall thickness and calcification (1,3,4,11,18,24,26,31). This functional deterioration impairs the conduit and buffering functions of arteries, leading to several pathological conditions, including hypertension, atherosclerosis, and stroke (1,4,18,26). A cross-sectional study revealed that arterial stiffness was lower in individuals with higher levels of cardiorespiratory fitness (23, 28). Furthermore, habitual aerobic exercise reduces arterial stiffness (10, 28).Adropin consists of 76 amino acids and is encoded by a gene, Energy Homeostasis Associated (Enho) (16), and expressed in multiple tissues, including the brain, heart, kidney, liver, pancreas, skeletal muscle, and small intestine (2, 32). Circulating adropin level decreases with age (7). Recent work showed that adropin is expressed in vascular endothelial cells and promotes nitric oxide (NO) release by regulating endothelial nitric oxide synthase (eNOS) expression via vascul...

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“…Whether adropin is actively secreted is controversial, as a recent publication failed to replicate experiments showing secretion of epitope-tagged adropin [18]. However, publications too numerous to be cited here have reported measurements of adropin in the circulation of humans, nonhuman primates, cows, rats and mice.…”

Section: Controversies and Contradictions In The Fieldmentioning

confidence: 96%

“…Another laboratory produced Enho -/-mice [18], and while a similar reduction of physical activity was observed there was no evidence of insulin resistance. Failure to replicate metabolic phenotypes in a mouse models between laboratories is not unprecedented, as genetic background and housing conditions can significantly affect phenotype [24].…”

Section: Controversies and Contradictions In The Fieldmentioning

confidence: 99%

Adropin – a circulating factor in metabolic control or a drop in the ocean?

Gao

Stevens

Butler

2016

Expert Review of Endocrinology & Metabolism

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Adropin Is a Brain Membrane-bound Protein Regulating Physical Activity via the NB-3/Notch Signaling Pathway in Mice

Cited by 106 publications

References 38 publications

First and third trimester serum concentrations of adropin and copeptin in gestational diabetes mellitus and normal pregnancy

First and third trimester serum concentrations of adropin and copeptin in gestational diabetes mellitus and normal pregnancy

Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults

Adropin – a circulating factor in metabolic control or a drop in the ocean?

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