Adsorption and release of ampicillin antibiotic from ordered mesoporous silica

Nairi, Valentina; Medda, Luca; Monduzzi, Maura; Salis, Andrea

doi:10.1016/j.jcis.2017.03.021

Cited by 127 publications

(69 citation statements)

References 71 publications

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“…147 Nairi et al postulated that ampicillin release under physiological conditions is strongly affected by the surface charge and not the pore size. 148 Similarly, Savimli and Yilmaz reported that the functionalization of MSNs with various groups, including amine, thiol and methyl can modulate the amount of amoxicillin loaded and released. 149 The introduction of ammonic groups greatly retarded the amoxicillin release from MCM-41.…”

Section: Other Nanoparticlesmentioning

confidence: 98%

Advancements on the molecular design of nanoantibiotics: current level of development and future challenges

Jijie

Barras

Teodorescu

et al. 2017

Mol. Syst. Des. Eng.

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Abstract.Numerous antimicrobial drugs have been developed and commercialized to kill and inhibit the growth of pathogenic microbes. The therapeutic efficiency of these drugs has however become often inadequate for the treatment of microbial infections, the reasons being multiple. Oral administration results often in only partial absorption and up to 50% of the active compound can be excreted in the urine. Furthermore, antibiotic therapy is also frequently accompanied by gastrointestinal complications, including vomiting, nausea and diarrhea. From a therapeutic point of view, the low solubility of antibiotics in lipid membranes presents a limitation for rapid and efficient treatment of infections. The preferred route for the delivery of antimicrobial drugs is the oral one; oral formulations capable of extending the duration of drug delivery and minimizing side effects have received much attention. The combination of antimicrobial agents with nanomaterials has been seen as a particularly promising strategy to overcome these limitations. Particulate formulations have proven their efficiency in achieving better pharmacokinetic profiles and improving the bio availability of several antibiotics. Antibiotic modified particles have shown their capability to protect some of the antimicrobial drugs from stomach acid and first-pass metabolisms in the gastrointestinal tract. Likewise, particle formulations can increase the circulation times of a drug and the local concentration gradient across absorptive cells. The present review describes the current status of different types of antibiotic loaded nano-systems. Key principles such as antibiotic loading, the release mechanism and the mode of action involved in pathogen killing or inhibition will be discussed in more detail. It is hoped that the general knowledge obtained here will help in the generation of advanced nanomaterials loaded with antimicrobials agents.Post-print 2

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Section: Other Nanoparticlesmentioning

confidence: 98%

Advancements on the molecular design of nanoantibiotics: current level of development and future challenges

Jijie

Barras

Teodorescu

et al. 2017

Mol. Syst. Des. Eng.

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“…30 Ordered MCM-41, SBA-15, and amino functionalized SBA-15-NH 2 exhibited different loadings of ampicillin due to the pore size and the surface charge density (sigma) of the sorbents. 31 The rattle-type magnetic gamma-Fe 2 O 3 /mSiO 2 spheres showed good reusability for at least four repealed cycles. 17 All of these studies give us the evidence and inspiration that mesoporous silica and those with metal iron modified have great research and practical value with their attractive adsorption performance.…”

Section: Introductionmentioning

confidence: 93%

“…Spherical MCM‐41 with the templates retained enhanced the adsorption capacities toward hydrophobic enrofloxacin, but inhibited the adsorption of hydrophilic norfloxacin . Ordered MCM‐41, SBA‐15, and amino functionalized SBA‐15‐NH 2 exhibited different loadings of ampicillin due to the pore size and the surface charge density (sigma) of the sorbents . The rattle‐type magnetic gamma‐Fe 2 O 3 /mSiO 2 spheres showed good reusability for at least four repealed cycles .…”

Section: Introductionmentioning

confidence: 99%

Metal‐based ionic liquid assisted synthesis of highly dispersed mesoporous Fe(III)/SiO₂ for enhanced adsorption of antibiotics

Chao

Jin

Jiang

et al. 2019

J of Chemical Tech & Biotech

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BACKGROUND Silica‐based adsorbents have shown huge potential and bright perspective in adsorptive removal of antibiotic contaminants for water remediation. To further simplify the synthesis process, stabilize the doped metal and improve the adsorption capacity, a highly‐effective metal iron‐doped mesoporous silica (meso‐Fe(III)/SiO2) adsorbent was in situ one‐step synthesized under the strategy of using metal‐based ionic liquid [(C12H25)3NCH3]FeCl4 as template and iron source. RESULTS Iron(III) species have been found highly dispersed in the confined space of meso‐SiO2 without pore blocking. Compared with the prototype and Fe‐impregnate meso‐SiO2 adsorbents, the meso‐Fe(III)/SiO2 exhibited significantly enhanced adsorptive removal of 95.6% and 93.8% for tetracycline (TC) and levofloxacin (LOF), respectively. The adsorption was controlled by diffusion processes and well described by pseudo‐second‐order kinetics equation and Langmuir isotherm model. Solution pH, co‐existing Na+ and Ca2+ exhibited significant impact on the adsorption process which is strongly related to π‐complexation, hydrophobic effect and electrostatic interactions. CONCLUSION The strategy of metal‐based ionic liquid assisted synthesis provide a promising approach to design and develop highly‐stable metal‐supported adsorbents. Furthermore, the excellent adsorption performance indicated the potential application of this meso‐Fe(III)/SiO2 in the removal of antibiotics from aqueous solutions. © 2019 Society of Chemical Industry

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“…Among LBADS, mesoporous silica materials (MSM) have received considerable attention, due to their unique properties, such as high surface area, controlled mesopore size, tunable pore diameter, thermal stability, biocompatibility, and modified release profile of active substance [9][10][11]. However, the release profiles of water-soluble drug, such as antibiotics, loaded into MSM have usually presented high-level burst release [12] which may be difficult to control and lead to cytotoxic effect.…”

Section: Introductionmentioning

confidence: 99%

Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection

et al. 2019

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Bone tissue inflammation, osteomyelitis, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against Staphylococcus aureus for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against Staphylococcus aureus (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against S. aureus and the highest cytocompatibility to human osteoblasts in vitro.

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Adsorption and release of ampicillin antibiotic from ordered mesoporous silica

Cited by 127 publications

References 71 publications

Advancements on the molecular design of nanoantibiotics: current level of development and future challenges

Advancements on the molecular design of nanoantibiotics: current level of development and future challenges

Metal‐based ionic liquid assisted synthesis of highly dispersed mesoporous Fe(III)/SiO₂ for enhanced adsorption of antibiotics

Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection

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Adsorption and release of ampicillin antibiotic from ordered mesoporous silica

Cited by 127 publications

References 71 publications

Advancements on the molecular design of nanoantibiotics: current level of development and future challenges

Advancements on the molecular design of nanoantibiotics: current level of development and future challenges

Metal‐based ionic liquid assisted synthesis of highly dispersed mesoporous Fe(III)/SiO2 for enhanced adsorption of antibiotics

Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection

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Metal‐based ionic liquid assisted synthesis of highly dispersed mesoporous Fe(III)/SiO₂ for enhanced adsorption of antibiotics