Adsorption and sensing of an anticancer drug on the boron nitride nanocones; a computational inspection

Wang, Chao; Shen, Lizhen; Wu, Liang

doi:10.1080/10255842.2020.1815716

Cited by 15 publications

(3 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…al. [ 52 ] using density functional theory. Results indicated that the boron nitride nanocones may be suitable candidates for the detection of 5-FU and can be utilized in electronic sensors.…”

Section: Resultsmentioning

confidence: 99%

Preparation, Characterization, and Drug Delivery of Hexagonal Boron Nitride-Borate Bioactive Glass Biomimetic Scaffolds for Bone Tissue Engineering

2022

View full text Add to dashboard Cite

In this study, biomimetic borate-based bioactive glass scaffolds containing hexagonal boron nitride hBN nanoparticles (0.1, 0.2, 0.5, 1, and 2% by weight) were manufactured with the polymer foam replication technique to be used in hard tissue engineering and drug delivery applications. To create three-dimensional cylindrical-shaped scaffolds, polyurethane foams were used as templates and covered using a suspension of glass and hBN powder mixture. Then, a heat treatment was applied at 570 °C in an air atmosphere to remove the polymer foam from the structure and to sinter the glass structures. The structural, morphological, and mechanical properties of the fabricated composites were examined in detail. The in vitro bioactivity of the prepared composites was tested in simulated body fluid, and the release behavior of gentamicin sulfate and 5-fluorouracil from glass scaffolds were analyzed separately as a function of time. The cytotoxicity was investigated using osteoblastic MC3T3-E1 cells. The findings indicated that the hBN nanoparticles, up to a certain concentration in the glass matrix, improved the mechanical strength of the glass scaffolds, which mimic the cancellous bone. Additionally, the inclusion of hBN nanoparticles enhanced the in vitro hydroxyapatite-forming ability of bioactive glass composites. The presence of hBN nanoparticles accelerated the drug release rates of the system. It was concluded that bioactive glass/hBN composite scaffolds mimicking native bone tissue could be used for bone tissue repair and regeneration applications.

show abstract

Section: Resultsmentioning

confidence: 99%

Preparation, Characterization, and Drug Delivery of Hexagonal Boron Nitride-Borate Bioactive Glass Biomimetic Scaffolds for Bone Tissue Engineering

2022

View full text Add to dashboard Cite

show abstract

“…When topically used, it can cause skin irritation, especially during pregnancy ( Oliveira et al, 2021 ). Therefore, it is extremely important to use the highly biocompatible, hydrophilic carriers to reduce such inherently damaged issues ( Frydenberg et al, 2020 ; Wang et al, 2021 ). In addition to an improvement of the therapeutic efficacy of 5FU and a reduction of adverse events, it is also crucial to quickly detect its presence in a biological environment by a simple detection method ( Yuksel et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Binding mechanism and SERS spectra of 5-fluorouracil on gold clusters

2022

View full text Add to dashboard Cite

The adsorption behaviour of the 5-fluorouracil (5FU) on small gold clusters AuN with N = 6, 8, 20 was evaluated by means of density functional theory using the PBE-D3 functional in combination with a mixed basis set, i.e. cc-pVDZ-PP for gold atoms and cc-pVTZ for non-metal elements. The binding energies between 5FU and gold clusters were determined in the range of 16–24 and 11–19 kcal/mol in gas-phase and aqueous media, respectively. The corresponding Gibbs energies were found to be around -7 to -10 kcal/mol in vacum and sigificantly reduced to -1 to -6 kcal/mol in water solution, indicating that both the association and dissociation processes are likely spontaneous. An analysis on the charge density difference tends to confirm the existence of a charge transfer from the 5FU molecule to Au atoms. Analysis of the surface-enhanced Raman scattering (SERS) spectra of 5FU adsorbed on the Au surfaces shows that the stretching vibrations of N−H and C=O bonds play a major role in the SERS phenomenon. A mechanism for the drug releasing from the gold surfaces is also proposed. The process is triggered by either the low pH in cancerous tumors or the presence of cysteine residues in protein matrices.

show abstract

“…As such, it is urgent to develop a method for the rapid identification of the threat of overdose drug for a timely life-saving medical intervention . To date, much effort has been developed to detect 5FU by different methods, for example, electrochemical and high-performance liquid chromatography (HPLC). , Although these devices provide valuable information for the detection of 5FU, it is still necessary to explore more convenient, easily operable, and nondestructive emission signal detection method. Fluorescence analysis has recently attracted significant attention owing to its ability to monitor the wide range of clinically important analytes. − …”

Section: Introductionmentioning

confidence: 99%

Fabricating Nanosheets and Ratiometric Detection of 5-Fluorouracil by Covalent Organic Framework Hybrid Material

Wang

Zhao

et al. 2021

Anal. Chem.

View full text Add to dashboard Cite

Covalent organic framework (COF) nanosheets (NSs) are a new member in the family of two-dimensional (2D) nanomaterials that received increasing attention. The ability to prepare COF NSs with rapid acquisition is of great importance to explore their distinctive properties and potential applications. Herein, we elaborate design a new COF hybrid material EB-TFP:Eu(BTA)4 as a sensing platform. In the process of ratiometric fluorescence detection of 5-fluorouracil (5FU), an anticancer drug, we realize the preparation of COF NSs. Interaction occurs between 5FU and COF hybrid material, where the interlayer π–π stacking of COF was weakened, benefiting the exfoliation of bulk COF to acquire 2D COF NSs. This strategy provides not only a sensitive and selective 5FU sensor but also a significant inspiration for engineering 2D COF NSs.

show abstract

Adsorption and sensing of an anticancer drug on the boron nitride nanocones; a computational inspection

Cited by 15 publications

References 46 publications

Preparation, Characterization, and Drug Delivery of Hexagonal Boron Nitride-Borate Bioactive Glass Biomimetic Scaffolds for Bone Tissue Engineering

Preparation, Characterization, and Drug Delivery of Hexagonal Boron Nitride-Borate Bioactive Glass Biomimetic Scaffolds for Bone Tissue Engineering

Binding mechanism and SERS spectra of 5-fluorouracil on gold clusters

Fabricating Nanosheets and Ratiometric Detection of 5-Fluorouracil by Covalent Organic Framework Hybrid Material

Contact Info

Product

Resources

About