Adsorption behavior of melphalan anti-ovarian cancer drug onto boron nitride nanostructures. Studying MTT assay: in vitro cellular toxicity and viability

Xia, Meng; Ye, Licui; Yang, Zhi‐Ling; Xiang, Rui; Wang, Jingyi

doi:10.1007/s11696-020-01405-w

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…Therefore, it is important to investigate the anti-cancer activity of inorganic molecules. In cancer research, the standard procedures are in vitro [45,46]. The studies show that anti-cancer agents affect with different mechanisms in different cancer types.…”

Section: Resultsmentioning

confidence: 99%

Analysis of Interactions of NHC Type Molecules and NHC-Ag Complexes with VEGFR-2 and DNA: A Molecular Docking Study

Üstün¹,

Şahin²

2021

Adıyaman University Journal of Science

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Molecular docking is an important tool in drug research. Thanks to these calculations, the type and magnitude of interactions of the molecules with target molecules are evaluated. It is also possible to perform more detailed analyzes than known experimental methods in an easy and economical way by using the results obtained with current scientific developments and examine interactions with different target molecules depending on bioactivity type. Cancer researches show that vascular endothelial growth factor is effective in the growth and proliferation of cancer cells. Inhibition of the receptor that regulates the release of this factor may be an efficient method for designing an anticancer agent. One of these receptors is VEGFR-2. This receptor can be used as a target molecule in cancer research. In addition, the interaction of molecules with DNA is important in terms of getting insight for future studies. In this study, the interaction of 1-allyl-3benzylbenzimidazolium, 1-allyl-3-(naphthylmethyl)benzimidazolium, 1-allyl-3-(anthracen-9-ylmethyl)benzimidazolium,chloro[1-allyl-3-benzylbenzimidazolium-2-ylidene]silver(I), chloro[1allyl-3-(naphthylmethyl)benzimidazolium-2-ylidene]silver(I), chloro[1-allyl-3-(anthracen-9-ylmethyl)benzimidazolium-2-ylidene]silver(I) with VEGFR-2 and DNA were analyzed by molecular docking methods.

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Section: Resultsmentioning

confidence: 99%

Analysis of Interactions of NHC Type Molecules and NHC-Ag Complexes with VEGFR-2 and DNA: A Molecular Docking Study

Üstün¹,

Şahin²

2021

Adıyaman University Journal of Science

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“…R. Li and Y. Wang [24] found that Ti-doping enhances the catalytic activity of BNFs for CO oxidation reaction. On the other side, the adsorption capability of B 11 N 12 Ni, [25] B 11 N 12 Ge, [26] B 11 N 12 Ga, [27] and B 11 N 12 Al [28] fullerenes for gemcitabine, melphalan, metformin and anagrelide drugs, is notoriously higher than their pristine counterparts. Moreover, B 11 N 12 M (M = Ga, Al, Mn, Fe, Mg, Ge) fullerenes have been proposed for CO, NO, NH 3 , and O 3 sensing, [22,29,30] exploiting the change of their electronic structure after gas adsorption.…”

Section: Introductionmentioning

confidence: 99%

Structural and Physicochemical Properties of Carbon Doped Boron Nitride Fullerenes: Effect of Doping Level and Atomic Arrangement

Escobedo‐Morales,

Salazar‐Villanueva,

Guatemala‐Vera

et al. 2023

Advcd Theory and Sims

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The effect of carbon doping on the structural and physicochemical properties of B12N12‐xCx [4, 6]‐fullerenes (0 ≤ x ≤ 6) (BNFs) is studied in the frame of the density functional theory. All non‐symmetry related isomers are modeled. Although carbon doping reduces the cohesive energy of the BNFs, most of them remain stable. It is found that the location of carbon atoms in the lowest‐energy isomers follows a definite sequence as the doping level increases. The results indicate that substitutional carbon lowers the gap energy and chemical hardness of BNFs, but it increases their electronegativity and electrophilicity index. Particularly, carbon doping makes BNFs more susceptible to nucleophilic attacks. Additionally, the charge redistribution and structural asymmetry generated by carbon doping endows BNFs with polar character. A dipole alignment parameter is introduced to elucidate some correlation between the atomic arrangement and the polarity of the systems. While carbon doping enhances the capability of BNFs to interact with other chemical species, possible toxicity concerns are highlighted. Finally, possible fingerprints to identify successful carbon doping through infrared and UV–vis spectroscopy are proposed.

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Self-Assembled Maslinic Acid Attenuates Doxorobucin Induced Cytotoxicity via Nrf2 Signaling Pathway: An In Vitro and In Silico Study in Human Healthy Cells

Banerjee

Hasan

Samanta

et al. 2022

Cell Biochem Biophys

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Adsorption behavior of melphalan anti-ovarian cancer drug onto boron nitride nanostructures. Studying MTT assay: in vitro cellular toxicity and viability

Cited by 7 publications

References 27 publications

Analysis of Interactions of NHC Type Molecules and NHC-Ag Complexes with VEGFR-2 and DNA: A Molecular Docking Study

Analysis of Interactions of NHC Type Molecules and NHC-Ag Complexes with VEGFR-2 and DNA: A Molecular Docking Study

Structural and Physicochemical Properties of Carbon Doped Boron Nitride Fullerenes: Effect of Doping Level and Atomic Arrangement

Self-Assembled Maslinic Acid Attenuates Doxorobucin Induced Cytotoxicity via Nrf2 Signaling Pathway: An In Vitro and In Silico Study in Human Healthy Cells

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