Adsorption of a blood protein on to hydrophilic sponges based on poly(2-hydroxyethyl methacrylate)

Bajpai, A. K.; Mishra, D. D.

doi:10.1023/b:jmsm.0000026380.40151.28

Cited by 32 publications

(15 citation statements)

References 11 publications

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“…Similar results have been reported for chitosan hydrogels (by Singh et al [ 29 ]). We showed earlier that the introduction of a cross-linker increases the glass transition temperature (Tg) of the polymer, which restrains the mobility of network chains at experimental temperature and, therefore, lowers both the amount of water sorption as well as drug release [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

Real time in vitro studies of doxorubicin release from PHEMA nanoparticles

Chouhan¹,

Bajpai²

2009

J Nanobiotechnol

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Background: Many anticancer agents have poor water solubility and therefore the development of novel delivery systems for such molecules has received significant attention. Nanocarriers show great potential in delivering therapeutic agents into the targeted organs or cells and have recently emerged as a promising approach to cancer treatments. The aim of this study was to prepare and use poly-2-hydroxyethyl methacrylate (PHEMA) nanoparticles for the controlled release of the anticancer drug doxorubicin.

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Section: Resultsmentioning

confidence: 99%

Real time in vitro studies of doxorubicin release from PHEMA nanoparticles

Chouhan¹,

Bajpai²

2009

J Nanobiotechnol

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“…Adsorption of BSA onto the composite materials was performed by the batch contact process reported elsewhere [20]. For protein adsorption experiment, protein (BSA) solutions were prepared in 0.5 M PBS (Phosphate buffer saline) at physiological pH 7.4.…”

Section: Protein (Bsa) Adsorptionmentioning

confidence: 99%

Designing of hydroxyapatite-gelatin based porous matrix as bone substitute: Correlation with biocompatibility aspects

Bundela¹,

Bajpai²

2008

Express Polym. Lett.

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In the present study polyacrylamide (PAm)-gelatin-hydroxyapatite (HA) composites have been synthesized by suspension polymerization method. The prepared composites were characterized by Fourier transform spectroscopy (FTIR) which revealed the presence of functional groups in the composite. The X-ray diffraction (XRD) studies indicated that HA powder was present in nano size. Thermogravimetric analysis (TGA) revealed that composite is more thermally stable than the polymer matrix alone. The morphology of composite studied by optical microscopy (OPM) and scanning electron microscopy (SEM) suggested that pore size was between 3–20 µm. The composites showed adequately good mechanical properties as evident from the varying compressive strength and modulus in the range 31.57±8.16 MPa and 745±388 MPa, respectively. The water sorption behavior was found to be dependent on the chemical composition of the matrix and the sorption data were used to calculate network parameters. The porosity of composite varied between 4 to 30.66%.The in vitro blood compatibility indicated that the adsorption of bovine serum albumin (BSA) varied from 0.11 to 0.24 mg•g–1, the percentage haemolysis was between 2.4 to 6.9% and the weight of blood clot formed on the composite surfaces were found in the range 11 to 52 mg

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“…PVA films have high mechanical strength and long-term temperature stability [11]. These properties of PVA have to led their use in several biomedical and industrial applications including contact lenses [12], ophthalmic materials [13], tendon repair [14], as sorbents for dye wastes [15,16], as sensors [17] and drug delivery system [18]. Some chemical hydrogels based on PVA are well known in literature [19].…”

Section: Introductionmentioning

confidence: 99%

Radiation induced crosslinking effect on semi - interpenetrating polymer networks of poly(vinyl alcohol)

Mishra¹,

Bajpai²,

Katare³

et al. 2007

Express Polym. Lett.

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Abstract. Semi-IPNs with varying contents of poly(vinyl alcohol) (PVA), poly acrylamide (PAM) and crosslinker N,N'-methylene bis acrylamide (MBA) were prepared by redox polymerization method. The structural and morphological properties were studied by Fourier transform infrared (FTIR) spectroscopy, environmental scanning electron microscopy (ESEM) and X-ray diffraction (XRD) methods, respectively. It was found that the surface of the hydrogel is heterogeneous with separated domains. XRD result shows the semi-crystalline nature of the semi-IPNs. The prepared semi-IPNs of different compositions were subjected to gamma irradiation (2 to 250 kGy) and the radiation induced effects on their strength of the semi-IPNs were studied by measuring the surface microhardness using a Vickers microhardness tester. Significant changes were observed in the Vickers microhardness, which were correlated with molecular architecture of the prepared semi-IPNs.

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Adsorption of a blood protein on to hydrophilic sponges based on poly(2-hydroxyethyl methacrylate)

Cited by 32 publications

References 11 publications

Real time in vitro studies of doxorubicin release from PHEMA nanoparticles

Real time in vitro studies of doxorubicin release from PHEMA nanoparticles

Designing of hydroxyapatite-gelatin based porous matrix as bone substitute: Correlation with biocompatibility aspects

Radiation induced crosslinking effect on semi - interpenetrating polymer networks of poly(vinyl alcohol)

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