Adsorption of antitumor antibiotic doxorubicin on MCM-41-type silica surface

Roik, N. V.; Belyakova, L. A.; Dziazko, M. O.

doi:10.1177/0263617416669504

Cited by 34 publications

(14 citation statements)

References 40 publications

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“…This observation is similar to that of the other authors. 24,[34][35][36] As a result, the data of PL also revealed the presence of DOX in the MCM-41.…”

Section: Photoluminescence Spectramentioning

confidence: 74%

Surface Functionalization of Doxorubicin loaded MCM-41 Mesoporous Silica Nanoparticles by 3-Aminopropyltriethoxysilane for Selective Anticancer 9 Effect on A549 and A549/DOX Cells

Dau

Pham

et al. 2021

Journal of Elec Materi

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In this study, MCM-41 mesoporous silica nanoparticles were successfully synthesized by the condensation of a tetraorthosilicate precursor on a template self-assembled by cetyltrimethylammonium bromide in alkaline. The small-angle x-ray diffraction patterns of MCM-41 indicate that silica nanoparticles possess hexagonal structures with a high degree of structural ordering. Transmission electron microscopy images show that the size of the MCM-41 particles is around 100-120 nm, and the pore sizes range from 2 nm to 4 nm. In addition, the specific surface area of MCM-41 obtained by Brunauer-Emmett-Teller analysis is as high as 987 m 2 .g À1 and the pore size extracted from nitrogen physical adsorption isotherms is in accordance with the TEM result. Thermogravimetric analysis, Fourier-transform infrared spectroscopy, Zeta potential measurements and photoluminescence measurements show that 3-aminopropyltriethoxysilane (APTES) and doxorubicin were grafted and loaded successfully onto MCM-41 nanoparticles. An assay on fibroblasts, A549 and doxorubicin-resistant A549/DOX cells indicates that the prepared MCM41 grafting APTES nanoparticles are safe to normal cells and toxic to cancer cells in vitro.

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“…This observation is similar to that of the other authors. 24,[34][35][36] As a result, the data of PL also revealed the presence of DOX in the MCM-41.…”

Section: Photoluminescence Spectramentioning

confidence: 74%

Surface Functionalization of Doxorubicin loaded MCM-41 Mesoporous Silica Nanoparticles by 3-Aminopropyltriethoxysilane for Selective Anticancer 9 Effect on A549 and A549/DOX Cells

Dau

Pham

et al. 2021

Journal of Elec Materi

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“…6a, b) and are shown in the table (Table 2). preference to a pseudo-first-order model that corresponds to the adsorption of the DOX cationic form at pH 7 (Roik et al 2017) (Table 2).…”

Section: Fig 5 Experimental Kinetic Curves Of Dox Sorption On the Surface Of Mnpsmentioning

confidence: 99%

“…8), the state of protonation which depends on the pH of the medium. In saline medium (pH − 6.8), the DOX fraction with protonated amino groups is maximum (Roik et al 2017), at the same time, under these conditions, only non-ionized hydroxyl groups are available on the Fe3O4 surface (Warren 2013), which does not promote ion-ion interactions and correspondingly high sorption properties.…”

Section: Adsorption Isothermsmentioning

confidence: 99%

Study of the adsorption activity of Fe3O4 synthesized by the solvothermal method in relation to doxorubicin

Kusyak

Storozhuk

et al. 2020

Appl Nanosci

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The solvothermal method synthesized magnetite (Fe3O4) and investigated the processes of immobilization of the cytostatic drug doxorubicin (DOX) on its surface in the medium of 0.9% NaCl solution. The size and morphology (transmission electron microscopy (TEM), crystalline phase magnetite formation (X-ray diffraction analysis (XRD), FTIR spectroscopy) and magnetic properties (vibration magnetometer (VSM), specific surface area and pore size were determined by the method of nitrogen thermal desorption were investigated for the synthesized samples. The adsorption processes were studied and the high adsorption activity of the Fe3O4 nanoparticles (MNPs) surface with respect to DOX was established in the model physiological environment. According to the studies, the adsorption equilibrium time is 45-90 min with up to 80% DOX extraction and maximum adsorption capacity (Amax) 17.5 mg•g -1 . The analysis of kinetic dependences and DOX adsorption isotherms using mathematical models that take into account the chemical interaction in the system indicates the monomolecular nature of adsorption (Freundlich model).Obtained MNPs can be potentially suitable for oncology applications specifically in the targeted drug delivery and adsorption materials of intracorporeal and extracorporeal detoxification of the body.

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“…The mean amount of CIP adsorbed onto each 1 g of MCM-41 was 131 ± 5 mg that corresponded to 65 ± 2.5% adsorption efficiency. The adsorption of positively charged CIP onto negatively charged surface of MCM-41 [51] resulted in the change of zeta potential value from −12.02 ± 0.91 mV to 11.04 ± 0.04 mV for MCM-41 and MCM-41-CIP, respectively. The change of the surface zeta potential after drug adsorption onto the mesoporous silica is well-known phenomenon [52,53].…”

Section: The Synthesis Of Mcm-41 and Cip Adsorption Onto Its Surfacementioning

confidence: 99%

Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection

et al. 2019

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Bone tissue inflammation, osteomyelitis, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against Staphylococcus aureus for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against Staphylococcus aureus (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against S. aureus and the highest cytocompatibility to human osteoblasts in vitro.

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Adsorption of antitumor antibiotic doxorubicin on MCM-41-type silica surface

Cited by 34 publications

References 40 publications

Surface Functionalization of Doxorubicin loaded MCM-41 Mesoporous Silica Nanoparticles by 3-Aminopropyltriethoxysilane for Selective Anticancer 9 Effect on A549 and A549/DOX Cells

Surface Functionalization of Doxorubicin loaded MCM-41 Mesoporous Silica Nanoparticles by 3-Aminopropyltriethoxysilane for Selective Anticancer 9 Effect on A549 and A549/DOX Cells

Study of the adsorption activity of Fe3O4 synthesized by the solvothermal method in relation to doxorubicin

Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection

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