Adsorption of Berberine Hydrochloride, Ligustrazine Hydrochloride, Colchicine, and Matrine Alkaloids on Macroporous Resins

Abstract

This research aims at identifying suitable resin adsorbents for efficient separation and purification of alkaloids from plant materials. The adsorption properties (equilibrium, kinetics, and column breakthrough) of four alkaloid model compounds (berberine hydrochloride, ligustrazine hydrochloride, colchicine, and matrine) on selected macroporous resins were studied. The adsorption equilibrium capacities and desorption ratios of the four model compounds on nine different macroporous resins were measured and compared. It was observed that the resins with a low polarity and high surface area offered a high adsorption capacity for all alkaloids. The pseudo-second-order adsorption rate equation fit well all the kinetic data, and the Langmuir and Freundlich isotherm equations correlate well the adsorption isotherms on the four resins. Among the nine resins studied in this work, the HPD300 resin was identified as the most promising adsorbent for alkaloids separation and purification because of its excellent adsorption and desorption properties for all four alkaloid compounds. The adsorption breakthrough experiment on the HPD300 resin using a mixture solution containing all four model compounds further confirmed the effective separation of alkaloids on the HPD300 resin.

Synthesis of Acryl Group-Modified Adsorption Resins and Their Adsorption Properties for Matrine and Oxymatrine in Aqueous Solutions

“…This was a reflection of particle surface 3D morphology and the ability of the adsorbing molecule to access this surface. 34 The 1/ n value is generally applied to estimate whether the adsorption easily takes place. The adsorption can easily take place when the 1/ n value is between 0.1 and 0.5; it is difficult to happen when the 1/ n value is between 0.5 and 1.0, and it is unable to occur when the 1/ n value is great than 1.…”

Optimization of the extraction and purification of Corydalis yanhusuo W.T. Wang based on the Q-marker uniform design method

“…During the purification process, we chose the macroporous resin as the impurity removal material based on previous studies [18][19][20], and nine resins with different polarity were investigated in the screening test.…”

Evaluation on the adsorption capability of chemically modified macroporous adsorption resin with ionic liquid

“…1/n greater than 1 rarely occurred. Table 4 shows that the values of 1/n for ECG and EGC on the three resins fall between 0 and 1, which indicated that adsorption easily occurred [34,35].…”