Adsorption of Beta-Blockers onto Poly(isobutylcyanoacrylate) Nanoparticles: Adsorption Model and Dielectric Interpretation

Block copolymers derived from photoreactive 2-oxazolines, 1. Synthesis and micellization behavior

“…The combined organic extracts were dried with Na 2 SO 4 and the solvent was removed by evaporation. Yield: 2.30 g (98%) of slightly blue crystals (6).…”

“…1 presents the results of the block copolymer syntheses derived from the monomers (3) - (6). In general the products show the expected molecular weights as determined by the monomer/initiator ratio combined with low polydispersity indices.…”

“…Due to their hydrophobic interior, hydrophobic molecules can be entrapped and thus solubilized and slowly released. Mostly block copolymers derived from poly(ethyleneglycol) are used to impart biocompatibility 4) whereas poly-(lactide) 5) , poly(N-isobutylcyanoacrylate) 6) and poly(aminoacid)s 7) serve as blocks for biodegradeability. In recent years poly(oxazoline)s were shown to serve as biocompatible polymers comparable to poly(ethyleneglycol)s on incorporation into vesicular drug delivery systems in vivo 8) .…”

Doxorubicin-loaded poly(butylcyanoacrylate) nanoparticles produced by emulsifier-free emulsion polymerization

“…7(b)], which might be from the increase of doxorubicin adsorption on the nanoparticles with the increasing pH3 and the cationic character of doxorubicin in an acidic condition. The zeta potential of drug‐loaded nanoparticles produced by emulsion polymerization in the presence of surfactants normally carries a negative charge 6, 30, 31. The negative charge might be associated with the carbanion, which has been assumed to be present at the termination end of the polymeric chain8, 9, 30 or/and the adsorption of anions from the aqueous phase 6.…”