Adsorption of Drugs on Nanodiamond: Toward Development of a Drug Delivery Platform

Mochalin, Vadym; Pentecost, Amanda; Li, Xuemei; Neitzel, Ioannis; Nelson, Matthew P.; Wei, Chongyang; He, Tao; Guo, Fang; Gogotsi, Yury

doi:10.1021/mp400213z

Cited by 166 publications

(119 citation statements)

References 48 publications

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“…21 The adsorption of drugs on the surface of well-dispersed ND particles may be very attractive, since ND could function as a "drug-reservoir or matrix" agent for topical drug delivery. 22 Additionally, ND was reported as a ultraviolet (UV) filter and photostability enhancer for drugs by absorbing and scattering light. 23,24 Antioxidant properties of ND were also reported, which act by promoting oxygen reduction.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system

Lim¹,

Kim²,

Kang³

et al. 2016

IJN

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The best strategy in the development of topical drug delivery systems may be to facilitate the permeation of drugs without any harmful effects, while staying on the skin surface and maintaining stability of the system. Nanodiamonds (NDs) play a key role with their excellent physicochemical properties, including high biocompatibility, physical adsorption, reactive oxygen species (ROS) scavenging capability, and photostabilizing activity. Z -average sizes of carboxylated ND (ND–COOH) agglutinate decreased significantly as the pH increased. Fluorescein-conjugated ND was observed only on the stratum corneum, and no sample diffused into the dermal layer even after 48 hours. Moreover, ND–COOH and ND–COOH/eugenol complex did not show significant toxic effects on murine macrophage cells. ND improved in vitro skin permeation >50% acting as a “drug reservoir” to maintain a high drug concentration in the donor chamber, which was supported by quartz crystal microbalance results. Moreover, ND–COOH could adsorb a drug amount equivalent to 80% of its own weight. A photostability study showed that ND–COOH increased the photostability ~47% with regard to rate constant of the eugenol itself. A significant decrease in ROS was observed in the ND–COOH and ND–COOH/eugenol complex compared with the negative control during intracellular ROS assay. Moreover, ROS and cupric reducing antioxidant capacity evaluation showed that ND–COOH had synergistic effects of antioxidation with eugenol. Therefore, ND–COOH could be used as an excellent topical drug delivery system with improved permeability, higher stability, and minimized safety issue.

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Section: Introductionmentioning

confidence: 99%

Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system

Lim¹,

Kim²,

Kang³

et al. 2016

IJN

View full text Add to dashboard Cite

show abstract

“…ND particles, which are capable of mediating improved efficacy and safety by forming complexes around the active agent while preserving its innate functionality (20)(21)(22)(23)(24)(25)(26)(27). ND safety and biocompatibility have been clearly demonstrated in numerous applications ranging from oncology to wound healing (28)(29)(30)(31)(32)(33)(34)(35). Similarly, hydrogels have been extensively used for tissue engineering and drug delivery applications due to their high biocompatibility (36).…”

Section: Significancementioning

confidence: 99%

Reducing posttreatment relapse in cleft lip palatal expansion using an injectable estrogen–nanodiamond hydrogel

Hong

Song

Lee

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Patients with cleft lip and/or palate (CLP), who undergo numerous medical interventions from infancy, can suffer from lifelong debilitation caused by underdeveloped maxillae. Conventional treatment approaches use maxillary expansion techniques to develop normal speech, achieve functional occlusion for nutrition intake, and improve esthetics. However, as patients with CLP congenitally lack bone in the cleft site with diminished capacity for bone formation in the expanded palate, more than 80% of the patient population experiences significant postexpansion relapse. While such relapse has been a long-standing battle in craniofacial care of patients, currently there are no available strategies to address this pervasive problem. Estrogen, 17β-estradiol (E2), is a powerful therapeutic agent that plays a critical role in bone homeostasis. However, E2's clinical application is less appreciated due to several limitations, including its pleiotropic effects and short half-life. Here, we developed a treatment strategy using an injectable system with photo-crosslinkable hydrogel (G) and nanodiamond (ND) technology to facilitate the targeted and sustained delivery of E2 to promote bone formation. In a preclinical expansion/relapse model, this functionalized E2/ ND/G complex substantially reduced postexpansion relapse by nearly threefold through enhancements in sutural remodeling compared with unmodified E2 administration. The E2/ND/G group demonstrated greater bone volume by twofold and higher osteoblast number by threefold, compared with the control group. The E2/ND/G platform maximized the beneficial effects of E2 through its extended release with superior efficacy and safety at the local level. This broadly applicable E2 delivery platform shows promise as an adjuvant therapy in craniofacial care of patients.nanomedicine | cleft palate | craniofacial medicine | nanodiamond | drug delivery

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“…The main bio-applications of nanodiamonds concern bio-imaging, drug delivery [148,[198][199][200] and tissue engineering [201]. This part will summarize the most recent contributions from the literature concerning these applications.…”

Section: Bio-applicationsmentioning

confidence: 99%

“…These issues are closely related to the drug binding strength and the cell environment (temperature, ionic strength, pH,…). Adsorption-desorption kinetics of doxorubicin and polymyxin B adsorbed on NDs have been investigated tuning their surface chemistry, purity or aggregation [211]. Drug adsorption and release are highly sensitive to NDs surface chemistry.…”

Section: Drug Deliverymentioning

confidence: 99%

Nanodiamonds: From Synthesis and Purification to Deposition Techniques, Hybrids Fabrication and Applications

Arnault

2016

Carbon Nanoparticles and Nanostructures

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The present chapter summarizes the recent advances in the production and the purification methods of nanodiamonds. The different strategies for seeding and patterning of surfaces are detailed. First reports of hybrids based on nanodiamonds are included like core shell particles or decoration with carbon dots or metallic atoms. Finally, an overview of applications for composites and nanomedicine is provided.

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Adsorption of Drugs on Nanodiamond: Toward Development of a Drug Delivery Platform

Cited by 166 publications

References 48 publications

Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system

Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system

Reducing posttreatment relapse in cleft lip palatal expansion using an injectable estrogen–nanodiamond hydrogel

Nanodiamonds: From Synthesis and Purification to Deposition Techniques, Hybrids Fabrication and Applications

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