Adsorption of Monovalent Ions to Phosphatidylcholine-Cardiolipin Membranes

Kotyńska, Joanna; Figaszewski, Zbigniew A.

doi:10.1080/1539445x.2015.1045075

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…The present work continues the research of Figaszewski and coworkers on the adsorption of monovalent ions in aqueous solutions of alkali metal chlorides on liposomal membranes (Dobrzyńska et al 2007 ; Kotyńska et al 2008 ; Kotynska and Figaszewski 2014 , 2015 ). PC was chosen for this study because it is the most widespread and dominant of the membrane phospholipids, and it is well understood and described in detail by biomembrane researchers.…”

Section: Introductionsupporting

confidence: 78%

Association of alkali metal cations with phosphatidylcholine liposomal membrane surface

2016

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Interactions of alkali metal cations (Li+, Na+, K+, Cs+) with phosphatidylcholine (PC) liposomal membranes were investigated through experimental studies and theoretical considerations. Using a microelectrophoresis technique, charge densities of experimental membrane surfaces were measured as a function of the pH of electrolyte solutions. Equilibria between the PC liposomal membranes and monovalent ions were mathematically analyzed and described quantitatively through a previously proposed theoretical model. Association constants between functional groups of PC and the studied ions were determined and used to define theoretical curves of membrane surface charge density versus pH. Theoretical and experimental data were compared to verify the model. The PC membrane was found to have the highest affinity for lithium ions, among the ions tested.

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Section: Introductionsupporting

confidence: 78%

Association of alkali metal cations with phosphatidylcholine liposomal membrane surface

2016

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“…Since no accurate data of the stability constants for forming connections exist in the literature, our team, as a first, has determined these parameters and introduced them to the world. This represents an original contribution to the knowledge of the biochemistry and biophysics of lipid membranes [30][31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Equilibria in DPPC-Diosgenin and DPPC-Diosgenin Acetate Bilayer Lipid Membranes: Interfacial Tension and Microelectrophoretic Studies

et al. 2020

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Interactions between components of model lipid membranes (spherical lipid bilayers and liposomes) are investigated here. Parameters characterizing equilibria in the 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)-diosgenin (Dio) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)-diosgenin acetate (DAc) membrane systems have been determined. The interfacial tension measurement of spherical lipid bilayers was based on the Young-Laplace’s equation using a homemade computer-controlled device. We assume a 1:1 complex in the DPPC-Dio and DPPC-DAc membrane systems. The parameters A 3 − 1 , the surface concentration of lipid membranes formed from these complexes, γ 3 , the interfacial tension of such membranes, and, K, the constant stability of these complexes were calculated. Microelectrophoresis was used for examinations of the surface charge density of lipid membranes. The values were obtained here from electrophoretic mobility data applying Smoluchowsky’s equation. The effect of pH (pH ranged of 2 to 10) on the electrolyte solution and the compositions of the membranes was analyzed. The obtained results indicate that the modification of DPPC membranes with both Dio and DAc causes changes in surface charge density values and shifts of the isoelectric point.

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Hyaluronic acid and phospholipid interactions useful for repaired articular cartilage surfaces—a mini review toward tribological surgical adjuvants

et al. 2017

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This mini review is focused on the emerging nexus between the medical device and pharmaceutical industries toward the treatment of damaged articular cartilage. The physical rationale of hyaluronic acid and phospholipid preparations as tribological surgical adjuvants for repaired articular cartilage surfaces is explored, with directions for possible new research which have arisen due to the therapeutic advance of the physiochemical scalpel. Because synovial joint lubrication regimes become dysfunctional at articular cartilage lesion sites as a result of the regional absence of the surface active phospholipid layer and its inability to reform without surgical repair, hyaluronic acid and phospholipid intra-articular injections have yielded inconsistent efficacy outcomes and only short-term therapeutic benefits mostly due to non-tribological effects. Parameters for hydrophobic-polar type interactions as applied to the lubricating properties of normal and osteoarthritic synovial fluid useful for repaired articular cartilage surfaces are discussed.

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Adsorption of Monovalent Ions to Phosphatidylcholine-Cardiolipin Membranes

Cited by 5 publications

References 20 publications

Association of alkali metal cations with phosphatidylcholine liposomal membrane surface

Association of alkali metal cations with phosphatidylcholine liposomal membrane surface

Equilibria in DPPC-Diosgenin and DPPC-Diosgenin Acetate Bilayer Lipid Membranes: Interfacial Tension and Microelectrophoretic Studies

Hyaluronic acid and phospholipid interactions useful for repaired articular cartilage surfaces—a mini review toward tribological surgical adjuvants

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