Adsorptive stripping differential pulse voltammetric determination of metoprolol at Nafion-CNT-nano-composite film sensor

Desai, Purvi B.; Srivastava, Ashwini K.

doi:10.1016/j.snb.2012.10.073

Cited by 36 publications

(14 citation statements)

References 33 publications

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“…Moreover CPE in the form of chemically modified carbon paste electrode (CME) have been widely used due to its enhancement in sensitivity of the electrochemical method [22][23][24][25]. Nanoparticles based CME's have been the spotlight because of their increased sensitivity, amplified response signal, and better reproducibility [26][27][28][29][30]. Magnetic nanomaterial applications have bench marked versatility in science and technology because of its exceptional properties (physical and catalytic, high aspect ratio) [31][32].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous electro-catalytic oxidative determination of ascorbic acid and folic acid using Fe3O4 nanoparticles modified carbon paste electrode

Kingsley

Desai

Srivastava

2015

Journal of Electroanalytical Chemistry

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Section: Introductionmentioning

confidence: 99%

Simultaneous electro-catalytic oxidative determination of ascorbic acid and folic acid using Fe3O4 nanoparticles modified carbon paste electrode

Kingsley

Desai

Srivastava

2015

Journal of Electroanalytical Chemistry

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“…The electrooxidation of UA at MIPCPE in the presence of interferences abundantly present in serum matrix 41 was investigated in order to evaluate selectivity of the sensor. To a 100 µM solution of UA, various interferent solutions having same concentration (100 µM) were successively added at definite time intervals and the current responses were checked amperometrically.…”

Section: Resultsmentioning

confidence: 99%

Voltammetric Determination of Uric Acid Based on Molecularly Imprinted Polymer Modified Carbon Paste Electrode

et al. 2015

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Molecularly imprinted polymer (MIP) for uric acid (UA) was synthesized by thermal polymerization using acrylic acid (AA) as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross linker and 2,2′‐azobis(2‐isobutyro) nitrile (AIBN) as initiator. The noncovalent interactions involved in four possible conformations of pre‐polymer complex were computationally studied by density functional theory. The hydrogen bond formation between UA and AA was confirmed by Fourier transform infrared (FTIR) spectrum of the MIP before extraction of UA. After extraction of the template, the molecularly imprinted polymer based carbon paste electrode (MIPCPE) was fabricated under optimized conditions. A significant enhancement in the electrocatalytic oxidation of UA was found at MIPCPE. The electrochemical behavior of sensor was investigated by cyclic voltammetry (CV) and differential pulse adsorptive stripping voltammetry (DPAdSV). The electrochemical impedance spectroscopy (EIS) studies revealed less charge transfer resistance (Rct) at MIPCPE than NIPCPE. Under optimized conditions, calibration curve was obtained with a linearity range of 0.5 µM to 100 µM and the limit of detection was 0.1 µM. The sensor showed good selectivity towards UA in the presence of interferents and was successfully applied for the determination of UA in spiked serum samples.

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“…Due to its thermal stability, chemical inertness, and mechanical strength, Nafion is widely used to modify electrodes in electrochemistry. Nafion-based sensors have been applied earlier for determination of metal ions [20][21][22][23][24] and important organic compounds [25][26][27][28][29][30][31][32][33][34][35][36] by AdSV. However, to our knowledge, Kyn determination using Nafion-modified electrodes has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Improved Voltammetric Determination of Kynurenine at the Nafion Covered Glassy Carbon Electrode – Application in Samples Delivered from Human Cancer Cells

Sadok

Tyszczuk‐Rotko

Mroczka

et al. 2021

Int J�Tryptophan�Res

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Nowadays, development of analytical methods responding to a need for rapid and accurate determination of human metabolites is highly desirable. Herein, an electrochemical method employing a Nafion-coated glassy carbon electrode (Nafion/GCE) has been developed for reliable determination of kynurenine (a key tryptophan metabolite) using a differential pulse adsorptive stripping voltammetry. To our knowledge, this is the first analytical method to allow for kynurenine determination at the Nafion-coated electrode. The methodology involves kynurenine pre-concentration in 0.1 M H2SO4 in the Nafion film at the potential of +0.5 V and subsequent stripping from the electrode by differential pulse voltammetry. Under optimal conditions, the sensor can detect 5 nM kynurenine (for the accumulation time of 60 seconds), but the limit of detection can be easily lowered to 0.6 nM by prolonging the accumulation time to 600 seconds. The sensor shows sensitivity of 36.25 μAμM−1cm−2 and 185.50 μAμM−1cm−2 for the accumulation time of 60 and 600 seconds, respectively. The great advantage of the proposed method is easy sensor preparation, employing drop coating method, high sensitivity, short total analysis time, and no need for sample preparation. The method was validated for linearity, precision, accuracy (using a high-performance liquid chromatography), selectivity (towards tryptophan metabolites and different amino acids), and recovery. The comprehensive microscopic and electrochemical characterization of the Nafion/GCE was also conducted with different methods including atomic force microscopy (AFM), optical profilometry, time-of-flight secondary ion mass spectrometry (TOF-SIMS), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV). The method has been applied with satisfactory results for determination of kynurenine concentration in a culture medium collected from the human ovarian carcinoma cells SK-OV-3 and to measure IDO enzyme activity in the cancer cell extracts.

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Adsorptive stripping differential pulse voltammetric determination of metoprolol at Nafion-CNT-nano-composite film sensor

Cited by 36 publications

References 33 publications

Simultaneous electro-catalytic oxidative determination of ascorbic acid and folic acid using Fe3O4 nanoparticles modified carbon paste electrode

Simultaneous electro-catalytic oxidative determination of ascorbic acid and folic acid using Fe3O4 nanoparticles modified carbon paste electrode

Voltammetric Determination of Uric Acid Based on Molecularly Imprinted Polymer Modified Carbon Paste Electrode

Improved Voltammetric Determination of Kynurenine at the Nafion Covered Glassy Carbon Electrode – Application in Samples Delivered from Human Cancer Cells

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