Adsorptive stripping voltammetric determination of ketoconazole in pharmaceutical preparations and urine using carbon paste electrodes

Shamsipur, Mojtaba; Farhadi, Khalil

doi:10.1039/b001452o

Cited by 45 publications

(22 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[9][10][11][12] In this work, we initially studied the reaction between clotrimazole (CT) (a drug containing an imidazole ring) and triiodide ions. We found that the protonated clotrimazole (CTH + ) is precipitated in the presence of excess I3 -ions as a (CTH)I3 ion pair.…”

Section: 8mentioning

confidence: 99%

“…7,8 We recently studied the electrochemical behavior and some chemical properties of various antifungal drugs containing piperazine or imidazole groups such as, ketoconazole in aqueous and non-aqueous media. [9][10][11][12] In this work, we initially studied the reaction between clotrimazole (CT) (a drug containing an imidazole ring) and triiodide ions. We found that the protonated clotrimazole (CTH + ) is precipitated in the presence of excess I3 -ions as a (CTH)I3 ion pair.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clotrimazole-Triiodide Ion Association as an Ion Exchanger for a Triiodide Ion-Selective Electrode

Farhadi

Maleki

2002

ANAL. SCI.

Self Cite

View full text Add to dashboard Cite

There has been continuing growth in the number of PVC membrane electrodes that have been prepared for a variety of substances. These electrodes can be prepared by incorporating any of the many ion-exchanger or neutral-sequestering agents within a plasticized PVC matrix, and used as very useful tools for clinical, chemical and environmental analysis. 1 and Schiff-base complexes 6 have been reported as possessing improved characteristics in selectivity. Despite an urgent need for a triiodide-selective sensor for a direct determination of iodine or an indirect determination of some important specific oxidizing substances in many industrial, medical and environmental samples, there has been limited reports on a triiodide ion-selective electrode in the literature. 7,8We recently studied the electrochemical behavior and some chemical properties of various antifungal drugs containing piperazine or imidazole groups such as, ketoconazole in aqueous and non-aqueous media. [9][10][11][12] In this work, we initially studied the reaction between clotrimazole (CT) (a drug containing an imidazole ring) and triiodide ions. We found that the protonated clotrimazole (CTH + ) is precipitated in the presence of excess I3 -ions as a (CTH)I3 ion pair. Since the obtained ion pair is very stable and insoluble in aqueous solutions, we therefore employed this ion pair to prepare a new solvent polymeric membrane sensor for selective monitoring of the I3 -ion. Applications of the proposed membrane electrode as an indicator electrode in the potentiometric titration of triiodide ions in solutions and in the indirect potentiometric determination of CT from pharmaceutical preparations were investigated. Experimental Reagents and chemicalsReagent-grade benzyl acetate (BA), 2-nitrophenyl octyl ether (NPOE), nitrobenzene (NB), acetophenone (AP), bis(2-ethyl hexyl) sebacate (DOS), tetrahydrofuran (THF), chloroform and high relative molecular-weight PVC were purchased from Aldrich and used as received. Reagent-grade CT, oleic acid (OA), tetraphenyl phosphonium chloride (TPPC), iodine and all of the anionic salts used (all from Merck) were of the highest purity available, and were used without any further purification. Aqueous solutions were prepared by dissolving the appropriate salt or diluting standard solutions as specified in doubly distilled water. ApparatusA WTW multilab 540 Ionalyzer (Germany) pH/mV meter was used for the potential and pH measurements at 25.0 ± 0.1˚C. The cell used was of the type Ag/AgCl, KCl (3 M) | internal solution KI3 (0.01 M) | PVC membrane | test solution | Ag/AgCl, KCl (3 M). The activities of anions were calculated using the Debye-Hückel procedure. 13 An LKB Model 4054 UV-Vis recording spectrophotometer with 10 mm quartz cells was used for absorbance measurements. Preparation of ion-exchanger (CTH)I3To a 10 ml aliquot of a 0.01 M aqueous CT solution containing a few drops of HCl (1 M) was slowly added a triiodide solution (0.01 M) with continuous stirring until precipitation was completed. The resulting brown ion-pa...

show abstract

Section: 8mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clotrimazole-Triiodide Ion Association as an Ion Exchanger for a Triiodide Ion-Selective Electrode

Farhadi

Maleki

2002

ANAL. SCI.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, Shamsipur et al [16] developed a triiodide PVC membrane sensor based on a charge-transfer complex of I 2 with 2,4,6,8-tetraazabicyclo [3.3.0] octane and used it as an indicator electrode in potentiometric titration of triiodide ions. We have recently studied the electrochemical behavior and some chemical reactions of ketoconazole (KC) (an antifungal drug) in aqueous and non-aqueous media [17,18]. Also, we have found that the protonated KC (as dication) is precipitated in the presence of I À 3 ions as (KCH 2 )(I 3 ) 2 ion pair.…”

Section: Introductionmentioning

confidence: 99%

Triiodide Ion-Selective Polymeric Membrane Electrode Based on a Ketoconazole-Triiodide Ion Pair

2002

Self Cite

View full text Add to dashboard Cite

A new triiodide ion‐selective PVC membrane sensor based on diprotonated ketoconazole‐triiodide, as (KCH2)(I3)2, ion pair, was proposed. The electrode has a linear dynamic range between 2.0×10−3 and 7.0×10−6 M with a Nernstian slope of −59.9±1.6 mV per decade and a detection limit of 3.0×10−6 M. The potentiometric response is independent of the pH of the solution in the pH range 2–8.5. The electrode can be used for at least 3 months without any considerable divergence in potential. It was applied as indicator electrode in potentiometric titration of ascorbic acid, hydroquinone from pharmaceutical preparations and triiodide ions in solution. The proposed triiodide membrane sensor was also used in development of a new, simple, fast, inexpensive and precise method for the determination of Ketoconazole in formulations.

show abstract

“…Ketoconzole has been titrated potentiometrically using perchloric acid as titrant [5]. Several different articles have been published for the determination of ketoconazole spectrophotometrically [23][24][25] , Voltametrically [26], by HPTLC [27], by HPLC [23,28,29] and by LC-MS [30]. The USP [13] Use mobile phase consists of diisopropylamine in methanol (7:3) conducted through C18 column.…”

Section: Column and Mobile Phasementioning

confidence: 99%

Micellar Liquid Chromatographic Determination of Lamivudine, Indinavir and Ketoconazole in Dosage Forms and Biological Fluids

2015

Pharm Anal Acta

View full text Add to dashboard Cite

A simple, reversed phase high performance liquid chromatographic method has been developed for the determination of lamivudine, indinavir and ketokonazole in pharmaceutical preparations, human plasma and urine. The method was conducted using A Shim-pack VP-ODS (150×4.6 mm i.d) stainless steel column at ambient temperature with ultra violet detection at 225 nm. Micellar mobile phase consisted of 0.07 M sodium dodecyl sulphate , 10% n-propanol, 0.3% triethylamine in 0.02 M phosphoric acid (pH 4.5) was used and pumped at a flow rate of 1.2 mL/ min . The calibration curve was rectilinear over the concentration range of (0.05-1.0) µg/mL and (0.2-5.0) and (0.3-5.0) µg/mL lamivudine , indinavir and ketokonazole respectively. The proposed method was successfully applied to the analysis of these drugs in some dosage forms. The method was extended to the in-vitro,

show abstract

Adsorptive stripping voltammetric determination of ketoconazole in pharmaceutical preparations and urine using carbon paste electrodes

Cited by 45 publications

References 27 publications

Clotrimazole-Triiodide Ion Association as an Ion Exchanger for a Triiodide Ion-Selective Electrode

Clotrimazole-Triiodide Ion Association as an Ion Exchanger for a Triiodide Ion-Selective Electrode

Triiodide Ion-Selective Polymeric Membrane Electrode Based on a Ketoconazole-Triiodide Ion Pair

Micellar Liquid Chromatographic Determination of Lamivudine, Indinavir and Ketoconazole in Dosage Forms and Biological Fluids

Contact Info

Product

Resources

About