Adult and Pluripotent Stem Cells

Hescheler, Jürgen; Hofer, Erhard

doi:10.1007/978-94-017-8657-7

Cited by 2 publications

References 305 publications

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Crosstalk between RNA m⁶A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells

Sun

et al. 2022

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Transposable elements (TEs) are parasitic DNA sequences accounting for over half of the human genome. Tight control of the repression and activation states of TEs is critical for genome integrity, development, immunity, and diseases, including cancer. However, precisely how this regulation is achieved remains unclear. To address this question, we develop a targeted proteomic proximity labeling approach to capture TE-associated proteins in human embryonic stem cells (hESCs). We find that the RNA N6-methyladenosine(m6A)-reader, YTHDC2, occupies genomic loci of the primate-specific TE, LTR7/HERV-H, specifically through its interaction with m6A-modified HERV-H RNAs. Unexpectedly, YTHDC2 recruits the DNA 5-methylcytosine(5mC)-demethylase, TET1, to remove 5mC from LTR7/HERV-H and prevent epigenetic silencing. Functionally, the YTHDC2/LTR7-axis inhibits neural differentiation of hESCs. Our results reveal both an underappreciated crosstalk between RNA m6A and DNA 5mC, the most abundant regulatory modifications of RNA and DNA in eukaryotes, and the fact that in hESCs this interplay controls TE activity and cell fate.

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Crosstalk between RNA m⁶A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells

Sun

et al. 2022

Preprint

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Progress in Biomaterials for Cardiac Tissue Engineering and Regeneration

et al. 2023

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Cardiovascular diseases are one of the leading global causes of morbidity and mortality, posing considerable health and economic burden on patients and medical systems worldwide. This phenomenon is attributed to two main motives: poor regeneration capacity of adult cardiac tissues and insufficient therapeutic options. Thus, the context calls for upgrading treatments to deliver better outcomes. In this respect, recent research has approached the topic from an interdisciplinary perspective. Combining the advances encountered in chemistry, biology, material science, medicine, and nanotechnology, performant biomaterial-based structures have been created to carry different cells and bioactive molecules for repairing and restoring heart tissues. In this regard, this paper aims to present the advantages of biomaterial-based approaches for cardiac tissue engineering and regeneration, focusing on four main strategies: cardiac patches, injectable hydrogels, extracellular vesicles, and scaffolds and reviewing the most recent developments in these fields.

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Adult and Pluripotent Stem Cells

Cited by 2 publications

References 305 publications

Crosstalk between RNA m⁶A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells

Crosstalk between RNA m⁶A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells

Progress in Biomaterials for Cardiac Tissue Engineering and Regeneration

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Adult and Pluripotent Stem Cells

Cited by 2 publications

References 305 publications

Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells

Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells

Progress in Biomaterials for Cardiac Tissue Engineering and Regeneration

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Product

Resources

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Crosstalk between RNA m⁶A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells

Crosstalk between RNA m⁶A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells