Adult cardiorenal benefits from postnatal fish oil supplement in rat offspring of low-protein pregnancies

Catta-Preta, Mariana; Oliveira, Daniel Alves; Mandarim-de-Lacerda, Carlos Alberto; Águila, Márcia Barbosa

doi:10.1016/j.lfs.2006.09.004

Cited by 19 publications

(9 citation statements)

References 84 publications

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“…These findings support the importance of nitrogen for healthy development and growth of the fetus. Similar results have been obtained in rats fed a low-protein diet by various other treatments, like perinatal administration of folate [113], metyrapone (11β-hydroxylase inhibitor) [114] or lazaroid (an inhibitor of lipid peroxidation) [115], as well as postnatal treatment with fish oil (ω-3 polyunsaturated fatty acids) [116] or atorvastatin (cholesterol-lowering and anti-atherosclerotic drug) [117]. …”

Section: Proposed Mechanistic Pathways Of Iugrsupporting

confidence: 69%

Long-Term Follow-Up of Intrauterine Growth Restriction: Cardiovascular Disorders

Demicheva¹,

Crispi²

2013

Fetal Diagn Ther

101

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In the modern world, cardiovascular disorders are the leading cause of mortality in developed countries, which in most cases undergo a long subclinical phase that can last decades before the first clinical symptoms appear. Aside from the well-known risk factors related to lifestyle and genetics, there is growing evidence that in a proportion of cases, the predisposition to cardiovascular disease lies in prenatal life. Moreover, numerous historical cohort studies and animal models have shown a clear association between low birth weight and increased cardiovascular mortality in adulthood, including increased risk of hypertension, diabetes, dyslipidemia and coagulation disorders in children and adults. Besides premature birth, low birth weight in the majority of the cases is caused by intrauterine growth restriction (IUGR), which affects up to 10% of all births. Several clinical and experimental studies showed that IUGR fetuses present signs of cardiac dysfunction in utero that persist postnatally and may condition higher cardiovascular risk later in life. The present review discusses the importance of the long-term cardiovascular follow-up of the patients who suffered early or late IUGR in utero, particularly with regard to the long-term epidemiological studies in adults, prospective studies in children and the possible mechanisms that trigger IUGR and cardiovascular programming. Considering the high prevalence of IUGR and the progressing availability of intervention strategies, it is of the highest clinical relevance to detect cardiovascular risks as early as possible, to introduce timely preventive interventions and to adapt the lifestyle, in order to improve the long-term cardiovascular health outcome of IUGR cases.

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Section: Proposed Mechanistic Pathways Of Iugrsupporting

confidence: 69%

Long-Term Follow-Up of Intrauterine Growth Restriction: Cardiovascular Disorders

Demicheva¹,

Crispi²

2013

Fetal Diagn Ther

101

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“…Experimental data have shown a significant positive correlation between the number of glomeruli later in life and birth weight [2], and epidemiological data have demonstrated that low birth weight contributes to the early onset of end-stage renal disease [3].…”

Section: Introductionmentioning

confidence: 99%

Hypertension and kidney alterations in rat offspring from low protein pregnancies

Villar-Martini¹,

Carvalho

Neves³

et al. 2009

Journal of Hypertension

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“…It is easy to understand the relevance of morphometry in studies regarding development (Catta-Preta et al, 2006), aging process (Aguila & Mandarim-deLacerda, 2001), and pathological diagnosis (Simmons, 2011). Morphometric tools are also valuable in basic scientific research because they allow the evaluation of tissue remodeling in organs such as the heart and aorta (Silva-Junior et al, 2011), adipose tissue (Bringhenti et al, 2010), pancreas (Marques et al, 2010;Frantz et al, 2011), kidney (Cunha et al, 2008), and uterus (Brasil et al, 2005).…”

Section: Morphometrymentioning

confidence: 99%

Quantitative Morphology Update: Image Analysis

et al. 2013

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FERNANDES-SANTOS SUMMARY:Quantitative morphology is a reliable tool in developmental, clinical and aging biology. Quantitative data of histological improvement and/or impairment due to dietary manipulations or pharmacological interventions draws the attention of countless researchers worldwide. Morphometry allows a wide range of two-dimension analysis to be performed, whereas image segmentation allows the measurement of a single structure or the determination of the intensity of its color after adequate immunostaining or even the area occupied by a specific sort of cell. When it comes to unbiased analysis, consideration should be given to suitable tissue perfusion, fixation and embedding, avoiding artifacts. Furthermore, tissue shrinkage should be taken into account. In order to ensure reproducibility, one of the most important principles in scientific research, and to allow different groups to be compared, image acquisition and image segmentation emerge as crucial steps and should be standardized. This paper aims to approach some important care for appropriate tissue processing and evaluation, and shows some practical examples of how morphometry and image segmentation can be applied to your experiment.

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Adult cardiorenal benefits from postnatal fish oil supplement in rat offspring of low-protein pregnancies

Cited by 19 publications

References 84 publications

Long-Term Follow-Up of Intrauterine Growth Restriction: Cardiovascular Disorders

Long-Term Follow-Up of Intrauterine Growth Restriction: Cardiovascular Disorders

Hypertension and kidney alterations in rat offspring from low protein pregnancies

Quantitative Morphology Update: Image Analysis

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