Adult coeliac disease: Prevalence and clinical significance

Cook, H. B.; Burt, Michael; Collett, Judith A.; Whitehead, Martin; Frampton, Christopher; Chapman, B. A.

doi:10.1046/j.1440-1746.2000.02290.x

Cited by 113 publications

(75 citation statements)

References 16 publications

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“…The prevalence of CD in New Zealand has been reported to be around 1.2% [13]. A similar figure has been observed in studies of adults in other industrialised countries such as Australia, the United States, Europe and the United Kingdom [14][15][16].…”

Section: Introductionsupporting

confidence: 71%

The Prevalence of Gluten-Free Diet at the University of Otago: A Cross- Sectional Survey

Hancock¹,

Al-Shaqsi²,

Badron³

et al. 2014

J Gastroint Dig Syst

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Aim: The objectives of this study were to: (1) determine the prevalence of the GFD in a New Zealand adult population, (2) investigate the reasons why people are on the GFD and (3) explore what factors limit adherence to the diet.Methods: This was a cross-sectional online survey of 3,000 students and 3,000 staff at the University of Otago, New Zealand, undertaken in July-August 2013. Participants were randomly selected from databases of students and staff at the University of Otago in July 2013. Survey questions included four main sections: demographics, dietary habits, motivating factors and barriers to following a GFD. The analysis compared the variables between students and staff as well as between people on the GFD and those not on the GFD, using a linear regression analysis model. Results:The overall response rate was 35.5% (2123 respondents). The prevalence of people currently on the GFD was 6.1% in this university population, while another 6.2% reported having previously tried the GFD. The prevalence of CD was 1.2%. Feeling unwell when eating food that contains gluten was the main reason for following the GFD in our study population. Poor availability along with cost of gluten-free (GF) foods was the main factors limiting adherence to the GFD. Conclusion:A significant proportion of a New Zealand university population is currently following or has followed a GFD. People follow a GFD for multiple reasons other than medical indications. People with special diets in a university setting appear to have difficulty accessing dietary options.

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Section: Introductionsupporting

confidence: 71%

The Prevalence of Gluten-Free Diet at the University of Otago: A Cross- Sectional Survey

Hancock¹,

Al-Shaqsi²,

Badron³

et al. 2014

J Gastroint Dig Syst

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“…[1][2][3] Undiagnosed CD in older adults is not associated with an increase in mortality but is associated with impaired bone density and lower ferritin levels. Furthermore, a minority of subjects with undiagnosed CD, especially women, will eventually be clinically diagnosed with CD.…”

Section: Discussionmentioning

confidence: 99%

“…Once thought to be rare, CD affects approximately 1% of the population [1][2][3] and appears to be associated with increased mortality [4][5][6] along with substantial morbidity, 7,8 much of which is preventable or reversible with the gluten free diet. 9,10 Well recognized are the gastrointestinal consequences of severe malabsorption with weight loss or growth failure, macro-and micronutrient deficiencies and a host of extra-gastrointestinal manifestations varying from autoimmune disorders to arthralgia to neurologic problems.…”

Section: Introductionmentioning

confidence: 99%

Morbidity and Mortality Among Older Individuals With Undiagnosed Celiac Disease

Murray¹

2011

Yearbook of Gastroenterology

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“…CD appears to be increasing in prevalence in many countries around the world, including New Zealand [7] . A population-based study conducted in the Christchurch region of New Zealand in the last years of the 20 th century using electoral roll records, showed a prevalence of 1.2% [8] . A further study in the same region documented more individuals being diagnosed with CD each year further data has shown increasing numbers of children diagnosed with CD during the first decade of this century, with more diagnosed after active screening in high risk groups [10] .…”

Section: Introductionmentioning

confidence: 99%

Presentation Patterns and Nutritional Impact of Coeliac Disease in New Zealand Children

Adamji

Whitehead

Day

2017

Journal of Gastroenterology and Hepatology Research

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RESULTS:Over the study period, 110 children were diagnosed at mean age of 7.37 years. The most common presenting symptom was abdominal pain. Sixteen children were diagnosed following screening in high risk groups, with 14 being asymptomatic. Eighteen children were iron deficient and twelve vitamin D deficient. CONCLUSIONS: CD was diagnosed in children of all ages, with various presentation patterns. Micronutrient deficiencies were commonly seen at diagnosis. Ongoing assessment of patterns of CD in NZ children is required. INTRODUCTIONCoeliac disease (CD) is an autoimmune disease of the small bowel, triggered by dietary exposure to gluten in genetically susceptible individuals [1] . Ingestion of gluten provokes immune-mediated damage to the small intestinal mucosa. The optimal management of CD currently involves institution of a life-long gluten free diet (GFD) [2] . The features of CD can develop at any age whilst on a gluten containing diet [3] . CD can have variable presentations from gastrointestinal symptoms to non-specific symptoms such as headaches or lethargy [4][5][6] . In addition, many individuals are increasingly identified consequent to active screening in groups at higher risk of CD (such as those with positive family history or type 1 diabetes) and a number of these individuals may be asymptomatic at diagnosis [7] . CD appears to be increasing in prevalence in many countries around the world, including New Zealand [7] . A population-based study conducted in the Christchurch region of New Zealand in the last years of the 20 th century using electoral roll records, showed a prevalence of 1.2% [8] . A further study in the same region documented more individuals being diagnosed with CD each year [9] . Subsequently AIM:To evaluate the presentation patterns of a cohort of children diagnosed with coeliac disease at Christchurch Hospital, New Zealand. METHODS: Children aged 15 years or less diagnosed with CD (based upon standard histological criteria) over a five year period were identified retrospectively. Presenting symptoms, anthropometry, serology and micronutrients were reviewed.

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Adult coeliac disease: Prevalence and clinical significance

Cited by 113 publications

References 16 publications

The Prevalence of Gluten-Free Diet at the University of Otago: A Cross- Sectional Survey

The Prevalence of Gluten-Free Diet at the University of Otago: A Cross- Sectional Survey

Morbidity and Mortality Among Older Individuals With Undiagnosed Celiac Disease

Presentation Patterns and Nutritional Impact of Coeliac Disease in New Zealand Children

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